脱发

AlopeciaAlajlan/AlopeciaScaring(Irreversible)NoneScaring(Reversible).XIntroduction&definitionAlopecia=HAIRLOSSBasichairanatomyandPhysiologyHairgrowthisverydynamicVellusandTerminalhairAlopecia=HAIRLOSSBasichairanatomyandPhysiologyHairgrowthisverydynamicVellusandTerminalhairIntroduction&definitionHowmanyhairsinthebody?5millionshairs;100,000inthescalpGrowthrate?0.3mm/dayforscalphairAndrogeneticAlopecia(MaleandFemalePatternHairLoss)MalePatternHairLossFemalePatternHairLossAndrogeneticAlopeciaaffectsupto50%ofmalesand40%offemalesAutosomaldominantwithvariablepenetrance85%:+vefamilyhistoryRoleofandrogensinthepathogenesis:AndrogeneticAlopecia5ALPHAReductaseTestosteroneDihydorTestosterone(Active)XFenastrideSystemicTreatmentMiniaturizationofTerminalHairsTopicalTreatmentMinoxidil2%and5%Solution(uncertainmechanism)AlopeciaAreataAlopeciaAreataaffectsupto2%30%:+veFamilyhistory75%:SelfrecoveryRoleofimmunesysteminthepathogenesisTypesofalopeciaareata:-localizedpartial-localizedextensive-alopeciatotalis-alopeciauniversalisAlopeciaAreataTreatment1.…Treatment2.IntralesionalCorticosteroidsSkinSensitizers(ImmunemodulatingRx)-Diphencyclopropenone(DPCP)-Anthraline-othersOtherRxTopicalsteroidsSystemicSteroidsCytotoxicRxPhototherapyMinoxidilHairTransplantXAnageneffluviumTelogeneffluviumAnageneffluviumAlwaysrelatedcytotoxicchemotherapyAcuteandseverealopeciaMostlyreversiblebutnotalwaysTelogeneffluviumChronicalopeciaAnemiawithchronicdiseaseCommonandNonespecificAdditionalcause:drugsWeightlossAcutebloodlossGeneralanasthesiaLowironOthersReversible(butmaybebecomechronic)Coulditbepreventable?VitiligoAlajlan/VitiligoAlajlan/VitiligoVitiligoIntroductiontoskinpigmentsAlajlan/VitiligoVitiligoIntroductiontoskinpigmentsDefinitionTypes:localizedandgeneralizedPathogenesisOtherassociateddiseasesNaturalcourseTreatmentAlajlan/VitiligoNosingleeffectiveRxTopicals:.Corticosteroids.ImmunomodulatorsLightTherapy:1.UVAorUVB2.UVA+Psoralen=PUVA(TopicalandSystemic)3.UVB=LaserSystemicTreatment:NOTUSEDSurgicalRx:.MelanocyteTransplant.SkinGraftsTransplantBleachingAgents:DepigmentallskinTreatmentAlajlan/Vitiligo•Tipsoffingersandtoes•Lips•Bonyprominence•Recurrence•Rarely100%repigmentationforlargearea•AdverseeffectofRxTreatmentPearls