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:(610083)(571101);;R28A167227193(2006)0620066203,,(ER),,ERER,ER,,1ERGreene[1]ERcDNA,ERERD,,A2F6[2]ER6q2427,ER140kb,87cDNA6322,1785bp66000ER,,,(estrogenreactiveelement,ERE),,[3](estro2genreceptor,ER),ER[4],(EstrogenReceptor,ER)(Pro2gestoroneReceptor,PR)1974Bethesda400,30%;ER(ER+)50%60%,(ER-)5%8%[3]SERMsSERMsER,,DNA,,ER,SERMs,SERMsERSERMs,[5,6],,,,,,,,[7,8],[9],,ERPR,()ERPR,[10](Hyperplasticdiseaseofbreast,HDB),,,[11,12],,,,,,,,,,,[13]22.1(ER)6620061286JournalofMilitarySurgeoninSouthwestChinaDec.,2006;8(6),,(isoflavones)(lignans)(coumestans),ER,ER,,,[14][15],()()()2.2ER[16],,,(ER)(PR),(AgNOR)ERPR,Wister40,()()()(),4(0.8mg/kg),,,0.446g/(kgd)(20)0.223g/(kgd)(10)0.02g/(kgd)(20),30,,ERPRERPR,E2,,(RXW)(Breastcapsual)8,,(E2)(P);(ER)(PCNA)E2P(P0.01,P0.05),E2(P0.01);ERPCNA(P0.01),,(ER)(PR),ERPR,1502040,(ER)(PR)(Tamoxifen),,3691.1%;80%,:,ER2.3ER,TAMERPR,,[12](Tamoxifen)(ER)150(90)(60)()(),36,12ER,31.1%91.1%;ER,80%20%;,P0.01,:(1),ER;(2)ER;(3)7686:Vol.8No.62.4ER()()6;,;4;,2,(ER)(PR),,,ERPR(P0.01),;,(P0.01),(P0.05P0.01),ERPR(P0.05P0.01),(P0.05);,,ERPR,,,,33.1,ER;,,ER,ER,3.2,,,,,3.3,,;,,,ER;,,,,,,1GreeneGL,GilnaP,WaterfieldM,etal.Sequenceandexpressionofhu2manestrogenreceptorcomplementaryDNA[J].Science,1986,231(4742):11501154.2.[J].,2001,22(3):115116.3RiceLW,JazaeriAA,ShupnikMA.EstrogenreceptormRNAsplicevari2antsinpre2andpostmenopausalhumanendometriumandendometrialcar2cinoma[J].GynecolOncology,1997,65(1):149157.4.[J].,2000,21(5):254255.5GoldsteinSR.Selectiveestrogenreceptormodulators:anewcategoryoftherapeuticagentsforextendingthehealthofpostmenopausalwomen[J].AmJObstetGynecol,1998,179(61):14791484.6.[J].,2000,27(5):262265.7,.[J].,2001,18(1):26.8,.[J].,2005,5(3):8890.9.[M].:,1993,(116):121.10.[J].,2001,14(2):241243.11.42[J].,2002,11(20):45.12,,.[J].,2005,24(1):6162.13,,.[J].,2001,4(4):6163.14BinghamSA,AtkinsonC,LigginsJ,etal.Phyto2oestrogens:WhereAreWeNew?[J].BrJNutr,79(5):393406.15,,.[J].,2002,27(11):805807.16,,.[J].(),2000,16(2):9899.(:2006209214)8620061286JournalofMilitarySurgeoninSouthwestChinaDec.,2006;8(6)