中药药代动力学研究的难点和热点

中药药代动力学研究的难点和热点作者：刘昌孝，LIUChang-xiao作者单位：天津药物研究院,天津药代动力学与药效动力学省部共建国家重点实验室,天津,300193刊名：药学学报英文刊名：ACTAPHARMACEUTICASINICA年，卷(期)：2005，40(5)被引用次数：31次参考文献(51条)1.ChenQHAbsorption,excretionanddistributionofderivativesofanthraquinonefromRheum,Chinesetraditionalmedicines1963(09)2.HanGZ中药代动力学19993.LiuCXSignificanceofpharmacokineticsinresearchanddevelopmentoftraditionChinesemedicines20014.LiuCX.XiaoPG.LiDPModernResearchofChineseMedicinalPlants20005.XiaoPG.LiuCXPharmacology,pharmacokineticsandtoxicologyofactiveconstituentsisolatedfromGinkgobilobaL20016.XiaoPG.LiuCXPharmacology,pharmacokinetics,toxicologyandtherapeuticsofRadixNotoginseng20017.LiuCX.XiaoPGPharmacology,pharmacokineticsandtoxicologyofactiveconstituentsisolatedfromRadixSalviaemultiorrhizae20018.XiaoPG.LiuCXPharmacology,pharmacokinetics,toxicologyandclinicaltherapeuticsofactiveconstituentsisolatedfromBerberisplant20019.XiaoPG.LiuCXPharmacology,pharmacokineticsandtherapeuticsoftraditionalChinesemedicine:RadixGlycyrrhiza200110.YangCM.HouSX.ZhangZRRecentadvanceinmetabolicchemistryoftraditionalChinesemedicine200111.LiuYM.ChenH.ZengFDTheadvanceinstudiesonpharmacokineticsofLigustrazininChina200112.SunLQEthnopharmacology,pharmacology,pharmacokinetics,toxicologyandtherapeuticsofFructusCrataegi200213.LiuCXPharmacokineticsstudiesinmodernresearchoftraditionalChinesemedicines200314.SmolenVF.BarileRG.TheophanousTGRelationshipsbetweendose,effect,timeandbiophasicdruglevels197215.FuHY.HoYZ.ZhouAXPerimarystudyonpharmacokineticsofMa--huang--tang,Gui--zhi--tang,Ying--Qiao--sanandSang--Ju--yinbyphamracedynamicmethodwithantipyreticmodel1992(01)16.FuHY.HoYZ.ZhouAXRe--studiesonpharmacokineticsofMa--huang--tang,Gui--zhi--tang,Ying--Qiao--sanandSang--Ju--yinbyphamracodynamicmethodwithdiaphoreticmodel1992(05)17.FuHY.HoYZ.ZhouAXRe--studiesonpharmacokineticsofMa--huang--tang,Gui--zhi--tang,Ying--Qiao--sanandSang--Ju--yinbyphamracedynamicmethodwithantiinflammationmodel1993(02)18.FuHY.ZhouAX.HoYZRe-studiesofpharmacokineticsofMa-huang-tang,Gui-zhi-tang,Ying-Qiao-sanandSang-Ju-yinbyphamracedynamicmethod1993(01)19.HaoMS.ZhanLM.GeJYCalcilationofhalf-lifebydeathratiomethod1985(03)20.LongSJ.XuLB.QiuYDeterminationoftoxicokineticparametersofGuan--mu--tong[期刊论文]-中药药理与临床2003(01)21.HuangYM.PanLH.WuXFStudyontoxicokineticsofWu-touingjectioninmice[期刊论文]-中国药学杂志1998(07)22.TaiTH.LiangCCPharmacokineticsoftetramethylpyrazineinratbloodandbrainusingmicrodialysis200123.XiangQJ.CbengG.ChenJMPharmacokineticstudyofShao-yaoandGan-caodecoctioninrats2000(04)24.YangK.PuXFOnsignificanceofgastroenterouospharmacokinetics[期刊论文]-中国实验方剂学杂志1998(01)25.HirokoI.SakacA.YukioOEffectofshassaikoto,aJapaneseandChineseherbalmedicinalmixture,onthemitogenticactivityofLipopolysaccharide..Anewpharmacologicaltesingmethod1987(01)26.MaJ.TangZ.LiZQSerumpharmacologicalapplicationinpharmacokineticstudiesofcomplextraditionalChinesemedicines1999(01)27.HuangX.ZhuangYM.XiaTOnzheng--knetics1994(06)28.HuangXTheconceptsofrecipe-derivedcomponentspectrumandtargetcomponentinvivo/serumandtheirsignificance1999(04)29.Fugh-BermanAHerb-druginteractious200030.Fugh-BermanAHerbalSupplements:Indications,ClinicalConcerns,andSafety200231.Fugh-BermanA.ErnstEHerb-druginteractions:reviewandassessmentofreportreliability200132.ErnstEHerb-druginteractions:potentiallyimportantbutwoefullyunder-researched200033.CrespiCL.GonzalezFJ.SteimelDTAmetabolicallycompetenthumancelllineexpressingfivecDNAsencodingprocarcinogen-activatingenzymes:applicationtomutagenicitytesting199134.JacobsBP.BrownerWSGinkgobiloba:alivingfossil2000(04)35.LeMarchandL.MurphySP.HankinJHIntakeofflavonoidsandlungcancer2000(02)36.IshiharaK.KushidaH.YuzuriharaMInteractionofdrugsandChineseherbs:pharmacokineticchangesoftolbutamideanddiazepamcausedbyextractofAngelicadahurica2000(34)37.DresserGK.BaileyDG.CarruthersSGGrapefruitjuicefeledipineinteractionintheelderly200038.WrightonSA.VandenBrandenM.RingBJThehumandrugmetabolizingcytochromesP450199639.WrightonSA.VandenBrandenM.StevensJC.ShipleyLA,RingBJ,RettieAE,CashmanJRInvitromethodsforassessinghumanhepaticdrugmetabolism:theiruseindrugdevelopment199340.AwangDV.Fugh-BermanAHerbalinteractionswithcardiovasculardrugs200241.DonovanJL.DeVaneCL.ChavinKD.TaylorRM,MarkowitzJSSiberianginseng(Elecutheroccussenticosus)effectsonCYP2D6andCYP3A4activityinnormalvolunteers200342.ChangTK.ChenJ.BenettonSAInvitroeffectofstandardizedginsengextractsandindividualginsenosidesonthecatalyticactivityofhumanCYP1A1,CYP1A2,andCYP1B1200243.LeeHC.HwangSG.LeeYGInvivoeffectsofPanaxginsengextractsonthecytochromeP450-dependentmonooxygenasesystemintheliverof2,3,7,8-tetrachlorodibenzo-p-dioxin-exposedguineapig200044.FanHR.HeF.LiQSStudyoninfluenceofginsenosideReoncytochromeP450isoformsbycocktailapproachusingprobedrugs,caffeine,chlorzoxazone,omeprazoleanddapsoneinrats200445.YuLS.ZengSCY3A4andP-glycoproteininsmallintestinalepithelialcellsandtheiraffectstosomeoraldrugs200146.HiroshiS.YuchiSRoleofmetabolicenzymesandeffluxtransportersintheabsorptionofdrugsfromthesmallintestine2000(01)47.LindonJC.HolmesE.Nicho