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11,23(12100952200032),1,,,,,,,1,2,,326,,1030d1,4,15%30%,5%,17.3%,43.1%2,5,14.4%3,33.57%,6.43%6,14.1%71513122,5,810,,1114,,,,,1,5,9,10,13,1:1.1,,,5;,,,,,2,151.2,,,1,21.3,,,,,,,,,,,,1,21.4,,3:;()nyhyzx07-036-02,22,,,,,2,3,6,15,,1,4,:2.1,,,,,,,,:;;,,,,,1,162.2,1,,,,,,,,,,,,,17192.3,,,,A,20,212.4,,,,,,,,2,5,172.5,,A,A6220101A,A,A,A,A,,21,,,2,,,21,-,,1,,-,7,,3,200400mg/L(500mg/L)1,2;100mg/L(660mg/L,20mg/L),200mg/L,100200mg/L2,6,22,1,(90mg/L)(40mg/L)4,,,23,(15%40%),(60%80%),(10%)1,2,44,4.1-,,,24,:4.1.1:(1):0.5g,10g,20g25,10g26,0.1g,12,,,,,2,25,27(2):5%,10%,20%:,5ml,5%10%0.5ml(10),,20%1ml(20),,,27(3):,,,,,,-,,200mol/L2,28,,4.1.2:(1):-,1,5-(2-)-3,4-29,,(2)-:-78%,,--(GoldStan2dard)3,30,31,,1.01.4mmol/L,1.2mmol/L,,1.22.0mmol/L,2.0mmol/L3,7,8,30,,,,RANBUT4.2Duffield,,32BatemanpH,pH-0.5,--0.65,pH,33Elliott-Martin-,,,34,35,,,,,,,,,,3655.150%500ml,,,,1(2/d,500g,2d,,10d2),,,:,,,,2,37(30g,7g/,2/d,35d2),,15.2,,,,1,2,,,,,,,,,,1,2Mandebvu,33,7220101(:78.43%,21.36%,0.155%,0.053%),,38Duffield,,30,31Nielsen,,,,,,,37,39,,,,,,406,,,:,,,,;,,,41;,;;,1.()M.:,2004,317321.2.J.,2008,(6):6266.3SakhaM,AmeriM,SharifiH,etal.BovineSubclinicalKetosisinDairyHerdsinIranJ.VeterinaryResearchCommunications,2007,(31):673679.4.D.:,2006.5,.J.,2004,(8):7879.6YameogoN,KanyandekweC,SawadogoGJ.RelationshipbetweenketosisanddairycowsbloodmetabolitesinintensiveproductionfarmsoftheperiurbanareaofDakarJ.TropAnimHealthProd,2008,(40):483490.7SuriyasathapornW,DaemenAJJM,Noordhuizen-StassenEN,etal.-hydroxybutyratelevelsinperipheralbloodandketonebodiessupplementedinculturemediaaffecttheinvitrochemotaxisofbovineleukocytesJ.VeterinaryImmunologyandImmunopathology,1999,(68):177186.8CookNB,WardWR,DobsonH.Concentrationsofketonesinmilkinearlylactation,andreproductiveperformanceofdairycowsJ.TheVeterinaryrecord,2001,148(25):769772.9WalshRB,WaltonJS,KeltonDF,etal.TheEffectofSubclinicalKetosisinEarlyLactationonReproductivePerformanceofPostpartumDairyCowsJ.JournalofDairyScience,2007,90:27882796.10LeslieKE,DuffieldTF,SchukkenYH,etal.TheInfluenceofNegativeEnergyBalanceonUdderHealthJ.NationalMastitisCouncilRegionalMeetingProceedings,2000,2533.11GrinbergN,ElazarS,RosenshineI,etal.-HydroxybutyrateAb2rogatesFormationofBovineNeutrophilExtracellularTrapsandBac2tericidalActivityagainstMammaryPathogenicEscherichiacoliJ.InfectionAndImmunity,2008,(7):28022807.12JorritsmaR,JorritsmaH,SchukkenYH,etal.Relationshipsbe2tweenfattyliverandfertilityandsomeperiparturientdiseasescommer2cialdutchdairyherdsJ.Theriogenology,2000,54:10651074.13HardengF,EdgeVL.Mastitis,Ketosis,andMilkFeverin31Or2ganicand93ConventionalNorwegianDairyHerdsJ.JournalofDairyScience,2001,84:26732679.14ButlerWR.RelationshipsofNegativeEnergyBalancewithFertilityJ.PennStateDairyCattleNutritionWorkshop,2006,5160.15MulliganFJ,DohertyML.ProductiondiseasesofthetransitioncowJ.TheVeterinaryJournal,2008,(176):39.16,,,.J.,2007,23(1):4244.17,,,.mRNAmRNAJ.,2008,28(4):465468.18FenwickMA,FitzpatrickR,KennyDA,etal.Interrelationshipsbetweennegativeenergybalance(NEB)andIGFregulationinliveroflactatingdairycowsJ.DomesticAnimalEndocrinology,2008,(34):3144.19VernonRG.Lipidmetabolismduringlactation:areviewofadiposetissue-liverinteractionsandthedevelopmentoffattyliverJ.Jour2nalofDairyResearch,2005,(72):460469.20BobeG,YoungJW,BeitzDC.InvitedReview:Pathology,Etiolo2gy,Prevention,andTreatmentofFattyLiverinDairyCowsJ.JournalofDairyScience,2004,87:31053124.21.J.,2009,(240):911.22SakhaM,AmeriM,RohbakhshA.Changesinblood-hydroxybu2tyrateandglucoseconcentrationsduringdryandlactationperiodsinIranianHolsteincowsJ.CompClinPathol,2006,(15):221226.23.D.:,2006.24EnjalbertF,NicotMC,BayourtheC,etal.KetoneBodiesinMilkandBloodofDairyCows:RelationshipbetweenConcentrationsandUtilizationforDetectionofSubclinicalKetosisJ.JournalofDairyScience,2001,84:583589.25,,,.J.,2003,39(12):34.26,,,.J.,2008,24(6):13.27,,,.J.,2003,24(4):8991.28CarrierJ,StewartS,GoddenS,etal.EvaluationofThreeCow-sideTestsforDetectionofSubclinicalKetosisinFreshCowsJ.Pro2QuestAgricultureJournals,2004,37:181.29,,,.J.,2003,12:1315.30DuffieldTF,SandalsD,LeslieKE,etal.EfficacyofMonensinforthePreventionofSubclinicalKetosisinLactatingDairyCowsJ.JournalofDairyScience,1998,81:28662873.31MelendezP,GoffJP,RiscoCA,etal.Incidenceofsubclinicalketo2sisincowsupplementedwithamonensincontrolled-releasecapsuleinHolsteincattleJ.PreventiveVeterinaryMedicine,2006,73:3342.32DuffieldTF,KeltonDF,LeslieKE,etal.UseoftestdaymilkfatandmilkproteintodetectsubclinicalketosisindairycattleinOntarioJ.TheCanadianVeterinaryJournal,1997,38(11):713718.33BatamanHG,BeemAE,StanleyCC,etal.CaseStudy:UsingUrinepHasaPredictorforKetosisinTransitionDairyCowsJ.TheProfessionalAnimalScientist,2005,(21):515520.34Elliott-MartinRJ,MottramTT,GardnerJW,etal.PreliminaryInvestigationofBreathSamplingasaMonitorofHealthinDairyCat2tleJ.JagricEngngRes,1997,(67):267275.35SergeiS,Likhodii,KathyMusa,etal.BreathAcetoneasaMeasureofSystemicKetosisAssessedinaRatModeloftheKetogenicDietJ.ClinicalChemistry,2002,48(1):115120.36XuC,WangZ.Comparativeproteomicanalysisofliversfromk