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:100083200220031431(HAI)(CAI)1420027120036301091,,MIC50MIC90,2002(NCCLS)(R)%(I)%(S)%(,2)//,,50%60%HAICAI115//,,2002200320002001;;;;2002-2003BacterialresistancesurveillancestudyonGram2negativebacilliinChinaLIJia2tai,LIYun,QIHui2min,onbehalfofChinaBacterialResistanceSurveillanceStudyGroupInstituteofClinicalPharmacology,PekingUniversity,Beijing100083,ChinaAbstractObjectiveTodeterminethedrug2resistantpatternofGram2negativeorganismsisolatedfrompatientswithhospitalacquiredinfection(HAI)orcommunityacquiredinfection(CAI)in31studywardsof14hospitalslocatedatdifferentareasinChina1MethodsAccordingtothepreviousprotocol,fromJuly1st2002toJune30th2003,atotalof1091pathogenicstrainsofGram2negativeorganismsisolatedfrom14hospitalswerecollectedforinvitrosusceptibilitytestusingtheinternationalstandardplatedilutemethodtoassaytheMIC50andMIC90asindicatorsrepresentingtheantibacterialactivityofantimicrobialagents1Theresistantrate(R%),intermediaterate(I%)andsusceptibilityrate(S%)ofdrugswerecalculatedaccordingtothecriteriainguidelinesofNCCLS(2002)1ResultsCarbapenemswerethemostactiveantibioticstestedagainstGram2negativeorganisms(exceptStenotrophomonasmaltophiliaandFlavobacteirium,thetwonon2fermenterswithhighresistancetocarbapenems)1Cefoperazone/sulbactam,piperacillin/tazobactam,cefepimandnewfluoroquinolonessuchasgentifloxacin,moxifloxacinandlevofloxacinalsoshowedexcellentactivityagainstGram2negativebacilli,however,therewere50%260%ofEscherichiacolistillresistanttofluoroquinolonesaswereportedbefore1ResistantratesofGram2negativebacillifromHAIpatientswere115timeshigherthanthosefromCAIpatients1ConclusionCefoperazone/sulbactam,piperacillintazobactamandgetifloxacinweremostinterestingantimicrobialagentswithbroad2spectrumaswellasinvitroactivityagainstnon2fermenters1Theresultsobtainedinthesurveillanceyearof20022003werecomparabletotheprevioussurveillanceyearof20002001aswellastotheresultsreportedfrominternationalsurveillanceprogram1Someofdifferenceinresistantratesamongthisreportwiththosereportedintheinternationaljournalswerediscussed1KeywordsGram2negativebacial;Bacterialresistancesurveillance;Microbialsusceptibilitytest;Communityacquiredinfection(CAI);Hospitalacquiredinfection(HAI)9120051281ChinJLabMed,January2005,Vol28,No11©1995-2005TsinghuaTongfangOpticalDiscCo.,Ltd.Allrightsreserved.,(ChinaBacterialResistanceSurveillanceStudyGroup,BRSSG)1998,,MIC,,NCCLS,MIC(R)%(I)%(S)%,2002200314,28(19981999,20002001)[1]149,23,,,MIC,(HAI)(CAI),HAICAI(CRF)20027120036301.:MIC2.:(ampicillin),(piperacillin)/(piperacillin/tazobactam)81,(cefazolin),(cefaclor),(cefuroxime),(cefprozil),(cefmatazole),(cefminox),(moxalactam),(ceftriaxone),(ceftazidime),(cefotaxime),(cefoperazone),/(cefoperozone/sulbactam)11,(cefditoren),(cefpodoxime),(cefepime),(imipenem),(meropenem),(panipenem),(gentamicin),(ciprofloxacin),(ofloxacin),(levofloxacin),(sparfloxacin),(getifloxacin),(moxifloxacin)3.:ATCC25922,ATCC278534.(SOP):,MIC5.(MIC):MIC,,,MIC,MIC50MIC90,NCCLS2002[2],,R%I%S%6.:SPSS14311808,1808,1766,9717%(1766/1808)675,3812%(675/1766);1091,6118%(1091/1766)1808,1021,5615%;282,1516%;173,916%;138,716%;72,410%;54,310%;45,215%;23,113%1091,27,215%(27/1091),686,6219%(686/1091);376,3415%(376/1091),2,0118%(2/1091)(%):(Haemophilusspp1)27215%;(Escherichiacoli)2352115%;0220051281ChinJLabMed,January2005,Vol28,No11©1995-2005TsinghuaTongfangOpticalDiscCo.,Ltd.Allrightsreserved.(Klebsiellaspp)2512310%(Kl1pneumoniae220,31);(Enterobacterspp1)100912%(Ent1cloacae68,Ent1aerogenes15,17);(Shigellaspp)25213%;(Serratiaspp)24212%;(Citrobacterspp1)23211%;(Proteusspp1)20118%;(Salmonellaspp1)40136%;(Morganellamorganii)40136%;(Pseudomonasaeruginosa)1501317%;(Acinetobacterspp1)1551412%((A1baumannii)112,43);(Stenotrophomonasmaltophilia)35312%;20118%;(Alcaligenesspp1)70164%;(Flavobacterumspp1)70164%;(Burkholderiacepacia)20118%;(Moraxellacatarrhalis)20118%,CAI,CAIHAI,CAIHAI,,HAICAI11HAICAIHAI(%)CAI(%)HAICAI26209181042719317115194912158114114100413131241231236171218321819022511215258713148835141384210812157142111150281810(678)7(374)(27)1079528MIC50MIC90,(R%)(I%)(S%)5713()1.,,MIC9024mg/L,MIC908mg/L()519%1313%,3312%2.2//,,,MIC90MIC90//10,,,,,,MIC90:/10MIC908,8,8,015,1,16,4,32,4,4mg/L;/MIC908,16,16,4,015,64,32,64,16,16mg/L,/MIC902810,8812%10010%8513%10010%31,MIC908mg/L10%,3019%,414%41(,)()1220051281ChinJLabMed,January2005,Vol28,No11©1995-2005TsinghuaTongfangOpticalDiscCo.,Ltd.Allrightsreserved.228MIC50MIC90(mg/L)(235)MIC50MIC90(220)MIC50MIC90(31)MIC50MIC90(25)MIC50MIC90(20)MIC50MIC90(27)MIC50MIC90256256322563225664256825601250156425632256162564160151280101601016/282162164401250150103101062825642564256225682564168256225612560156443218825622562256112821280112501516256225622561128225624015160156401564112224015401564015320125012501250125012501501125101125801125201125012501125012501031010620106264010316401031128010164010311010080100801125201125801125401031011250106201250103101062011253201031320103164010162011258010080100811280151281256010314015320101601016/015801258015801031015015101008010160125320112532011