叶酸受体介导的靶向给药研究进展

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*400016R94A1001-0971200603-0178-042005-11-09Tel023-68485078E-maillfyun82@126.com*Tel023-68485078E-mailzhaojing@cta.cq.cn1986folicacidfolateFAFAfolatereceptorFRFAFA-FAFRFA1FAFAFAFAFRFAFRFRMr38~40ku3α-FRβ-FRγ-FRFRβ-FRFR112100~300α-FRβ-FRγ-FR3FRβ-FR1FR%2330093%1700075%3930091%3180043%2890038%16940037%20500032%250073%1520022%2FRFA5-5-510-KD≈10-10molL-1FRFAFR871ForeignMedicalSciencesSectionofPharmacy2006Jun333FAFAFR14FA-FRFA-/FRpH75FA-/FRFR1FR3FRMRIPET5FAγFRFRFRFR111In67Ga99mTc64Cu-FAFAFR23672/67Ga-DF-FA111In-DTPA-FA99mTc-HYNIC-FA99mTcCO3-DTPA-FA/409±195350±10055.0±19.29.0±0.1/124±4733.3±9.828.2±14.81.4±0.1/11±331.1±9.75.78±2.920.43±0.04/2.6±0.91.00±0.340.26±0.030.07±0.0167Ga-DF-FA67--111In-DTPA-FA111--99mTc-HYNIC-FA99m--99mTcCO3-DT-PA-FA99m-DTPA-Ke689111---111In-octadentate-DTPA-FA111----111In-DTPA-NOON-pteroate99m--99mTc-DTPA-FA99mTc----D--99mTc-EC20/111In-DTPA-FA67Cu-FAFR111In-97120066333DTPA-FAFolateScanⅡ3582%1044.1-BNCT10BαLi+10µmγ10BBNCT10BSudimack11PEGDSPEKnido-7-CH3CH215-78-C2B9H11--FA-PEG-DSPE-PEG-DSPEKB587µg10B10-942.9µg10B10-94.2FALadinoFAFA-FRSK-OV-3LoVoHeLaSW620KBIC50=10-10~10-11molL-1Aronov12FA-PEG-PtFRM109PtParan-jpe13CPTFACPT16Yoo14FADOXPEGα-ω-DOX-PEG-FAKBIC50=5.6µmolL-1DOXIC50=9.8µmolL-123dDOX-PEG-FADOX40%4.3Kim15FARNA---pSUPER-siGFP-PEI-PEG-FAGBF-KB90%FARNA--pSUPER-siGFP-PEI-PEG40%FRYang16antisense-EGFR-ODN---DSPE-PEG-FAKB1hMTTKB50%FA10%4.4TAAFRLu17BALB/c5×106FRM109-KLH-FITC4dFA-FA-FITC1800nmolkg-1PBSLu17L1210ADBA7891114FA-FITC1800nmolkg-1IL-2250kuIFN-α75kuFA-FITC5FRFRTurk18FA-EC20γEC20EC20FRFAFA-EC20FRChen19FA081ForeignMedicalSciencesSectionofPharmacy2006Jun333NIR2-FALPSLPS48hNIR2-FA2nmolL-1NIR2-FA6001.2µmolL-15minNIR2-FAFANIR2-FA1.1FRPaulosa20FRFAFA-EDA-FITC500nmolL-1kg-114710131619dFR30%6-FAMrFRFR+FRFAFAFR1CancerFactsandFigures2002AmericanCancerSocietyInc.At-lantaGeorgiaUSA

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