小儿癫痫的药物治疗原则

2AEDsAEDsTCLGSfelbamete++++++gabapentin++----lamotrigine++++++vigabatrin++++--tiagabine++????topiramate+++/-+/-+/-+/-clobazen++++++oxcarbazepine+++/-+/---zonisamide++-++?:+,-,+/-AEDs,AEDsVPACBZPBPHTAEDsGTC,,;,;,,AEDsAEDs,,,,AEDs,AEDs,AEDs,,,,,,;,,,AEDs,,,,,;,AEDsACTH,85%AEDs,,,,4AEDsAEDsGABA,,AEDsGABA,,AEDs,2,AEDs,,,,,,3%10%,8,Stevens-Johnson1%(4/3500),016%,915%,19%,19%,(1998-08-20):(710004),,1,,;,,,,2,9119991141©1994-2007ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.(VPA)(PB)(CBZ)(PHT)(PRI);VPA(CZP)(DZP);ACTHVPACZPDZP;LennoxVPACZPDZP;CBZPBVPAPHTPRI;CBZ,PBVPAPHT;VPACBZPB10,,,,,;[1]3,,70%80%,,,,,,,,,,;,,4,,,:;;,,;,,,,20%30%6%12%[2]5,(),,,,,;,,,45mg/L,912mg/L,,,,,,6,,,,510,,517,7,,,,23,2,3,,,,0219991141©1994-2007ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.:,;;()();,,9911912,3913,,,;;914,915,:,,,;,,[3],,,,-1BeydounA.Monotherapytrialsofnewantiepilepticdrugs.Epilepsia,1997;38(suppl9):212JallonP.Theproblemofintractability:thecontinuingneedfornewmedicaltherapiesinepilepsy.Epilepsia,1997;38(suppl9):373PeruccaE,GramL,AvanziniG,etal.Antiepilepticdrugsasacauseofworseningseizures.Epilepsia,1998;39:5(1998-08-20):(,100020),1946,(WHO),,,,,--1111,(),,,,,1219991141©1994-2007ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.