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:(,710004)6254(CBZ)(VPA),CBZ11%,VPA15%17(27%),16(26%)50%,,Thedrugtreatmentof62childrenwithintractableepilepsyHuangShaoping,HeGuangzu,ChenZhengqi,etalXianMedicalUniversitySecondAffiliatedHospital,Xian710004KeywordsChildrenEpilepsyDrugtreatmentAbstractObjectiveToevaluatetheeffectivenessofanti-epilepticdrugmonotherapywithlargedosageandpoly2therapyintreatmentofintractableepilepticchildren.Methods54patientsreceivedlargedosesofcarbamazepine(CBZ)orvalproateacid(VPA)underthemonitoringserumconcentrations.Thosewithnoeffectandwithcombinedseizuretypesreceivedpolytherapy.ResultsCompleteseizurecontrolwereobservedin11%and15%ofpatientswithCBZandVPAtreatmentseparately.Serumconcentrationsofbothdrugwereintheuppertherapeuticrangeorwereaboveit.Inourstudyseizurefreewereseenin27%ofpatientsandmorethan50%reductioninseizurewasfoundin26%ofpa2tients.ConclusionThemonotherapywithlargedosageandpolytherapycouldbeconsideredinintractablecases.Butthemonitoringofserumlevelsshouldbedonetoavoidover-dosereaction.70%80%,20%30%,10162,234,325,4341,2124,512110,31811516,396301623:13,8,7,West6,Lennox-Gastaut11,5,4,8,2,1302,259CTMRI,42,15,9,8,6,4:23211,1333,112,8,,;8,,(CBZ)(VPA)(PB)VPA,:;50%;50%:28CBZ,3(11%),9(32%),16CBZ(2534)mg/kg,(267)mg/kg35,(10171414)mg/L,(1113115)mg/L,512mg/L,17(1213)mg/L,636120003153©1994-2007ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.(15%),6(23%),2,26VPA(3560)mg/kg,(448)mg/kg,(1081313317)mg/L,(119171018)mg/L,120mg/L152,1,,1:81(13%),2(25%)CBZVPA47,8(17%),CBZ2,VPA6,13(28%)4,1,1,17(27%),16(26%),53%:4,1,3,33,250%,133111,23[1],1[2],,12,,,,,,23,[1],,,2,1,,,3122080,[3],,,54CBZVPA,7(13%),15(28%)50%,CBZVPA,CBZVPA(153)mg/kg(2515)mg/kg,(612211)mg/L(68122113)mg/L,CBZVPA(267)mg/kg(448)mg/kg,(1113115)mg/L(119171018)mg/L3017,,546,2CBZ,4CBZVPA,,,,,,,,,5,,,,,,,,[1],[4,5],,,CBZPB,PBVPA,VPA,CBZPB,,1,,,46120003153©1994-2007ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.:whenisepilepsyfullyintractable?Epilepsia,1996;37(suppl1):602SteffenburgU,HedstromA,LindrothA,etal.Intractableepilepsyinapopulation-basedseriesofmentallyretardedchildren.Epilep2sia,1998;39(7):7673LesserRP,PippengerCE,LudersH,etal.High-dosemonothera2pyintreatmentofintractableseizures.Neurology,1984;34(6):7074LivingstioneJH.Managementofintractableepilepsy.ArchDischild,1991;66(12):4545HomesGL.Intractableepilepsyinchildren.Epilepsy,1996;37(suppl3):14(1999-03-151999-10-08)(:):730000,(),(),()D-43()D-,D-:43,19961997[1](),29,14,314,11.536(2313),7(43)18,:D-,,:D-D-(Nycomed),D-D-1.5mg/LD-,100IU/kg,,2D-:U:43D-22(51.2%),10,43.5%(10/23),8,61.3%(8/13),2,50.0%(2/4),2,66.7%(2/3),D-D-(P0.05),D-50.0%(18/36)57.1%(4/7),(P0.05)438(280630)109/L,2(300420)109/L;D-22,5(320630)109/L,(P0.05)22D-2,D-(115mg/L)12:D-,,,43,D-51.2%,0,(P0.01),D-,,D-(P0.05),,(FDP)FDPD-,,[2],(P0.05),D-,D-D-12/22(54.5%),,1,,..,1981;19(4):2412,,,..,1990;13(6):366(1998-06-191999-10-22)(:)56120003153©1994-2007ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.