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3322002545:31400014.5331.3435.1839.8744.5945.0645.2851.2551.8451.77t1FETIso(10-4)(min)135102030406090120(h)0.01670.05000.08330.16670.33330.50000.66671.0001.5002.00FETIso(10-4),;(MAC),,,-,,11.1ASA1220,2545,5060kg,,AB,A,BAB1.2,Ohmeda210DatexUltima,Vt8ml/kg,f15/min,PetCO235mmHg5min,O21L/min;OhmedaTec4(BOCHealth)1.5%;135102030406090120minIso(FETIso/104)1.3[1]AFETIso(10-4),FETIso,lgFETIso,lgFETIso=1.6376+0.04527t(r=0.8826):43.4136e0.1042t,;,FETIso(FETIso’),lg(FETIso’-FETI2so),lg(FETIso’-FETIso)=1.4352-5.1098t(r=-0.9579):27.2380e-11.7658t,-,lgFETIso(t)=-FETIso(t)/104=43.4136e0.1042t-27.2380e-11.7658tB,(PE%)Casiof3600P22.1FETIso(10-4)12.2(Iso)-,20ASA12,1L/minO21.5%Iso,Iso(FETIso)A10FETIso;B10,(PE%)1.FETIso(t)/104=43.4136e0.1042t-27.2380e-11.7658t;2.1min+30.3%,10%FETIso;IsoAbstractObjectiveTosetuptheconcentration-timemathematicalmodelinisofluranceinhalinganesthesia,andtoevaluatethereliability.Method20generalanesthesiapatientsofASA12werecontinuallygiven1.5%Isovolatilizaljartargetconcentrationwith1L/minO2aftertrachealcannula,estimatedFETIsobyanesthesiagasmonitor.GroupAsetupmathematicalmodelwithFETIsoandtime.GroupBcalculatedtheoryvalueaccordingtoestablishedmodel,analysePE%comparedwithactualvalue.ResultsMathematicalmodelisFETIso(t)/104=43.4136e0.1042t-27.2380e-11.7658t.PE%is+30.3%in1min,inotherspotarelessthan10%.ConclusionMathematicalmodelcouldaccuratedlypredictFETIso,Isotargetconcentrationhavenotbeenobtainedattheendofexperiment.Keywordsisoflurance,pharmacokinetic,mathematicalmodel20025453332min13510203040609012021.128.533.640.344.445.746.548.250.853.514.731.134.939.643.944.745.850.952.152.3PE%#+30.3-9.1-3.9+1.7+1.1+2.2+1.5-5.6-2.6+2.2#:=(-)/:31140023,,(),,,[2]PetCO2,,();,-AB,1min,10%,,MAC,,1L/min,,1,,..1.:,1996,1015.2RehbergB,BouillonT,ZinserlingJ,etal.Comparativepharmacodynamicmodelingoftheelectroencephalography-slowingeffectofisoflurane,sevoflurane,anddesflurane.Anesthesiology,1999,91(2):397405.2000620013,,11.140,26,141956,4567kg,ASA16,8,2,3,4,7(4,3)100mg1.222G,,,1%0.25%20ml25ml,34,6,,0.2%,100ml,2ml/h0.5ml,15:;;1.312,3280%,820%,100%12,,22G,,25mm,,,,,,,,,,,,1,..,1996,12(1):24.2,,..1.:,1995,546.