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,,,,,(,400042):,:,,.,,,.:;;:R972+.5:C:100023002(2000)0420241206,.,B2(B2endorphin),,(nalox2one),L2,.(protirelin),(thyrotropin2releasinghormone),.,,1981Holaday[1].É,.11.1:,,,iv5-10mgkg-1,2,,,[2];icv10Lg:1999209214:2000201214:(1940-),,,,,.[3].:4kPa,1h,iv5mgkg-1,(meanarterialpressure,MAP),(20.47.6)h,(2.81.6)h,P0.01;iv2-2.5mgkg-1,MAP,(leftventricularsystolicpressure,LVSP),,(dpödtmax),(Vpm),5.33kPa,,(Lo).5h4.67kPa,(8.91.0),(24.34.4)mLkg-1,P0.01[4-6].:1ö3,iv5mgkg-1,,,,,,MAP,,.,,,(pH,,,).,[7-9].1.2,ia5mgkg-1,[10].1.3,,iv4mgkg-1[11].1.44000m,5.86kPa,1h,iv5mgkg-1,MAP,LVSP(dpödtmax)[12].1.5(BIM2Ê),,,MAP8.0kPa,14220008;14(4):241-24630min,60min,,,,,;ö(nitricoxideöendothelin,NOö),(angiot2ensin2convertingenzyme);,,.1.62,5mgkg-1[11].1.7(anisodamine),[11].1.8,(dopamine,DA),(amrinone),D2ICI174864,22,,[13-15].,,,3,,,iv,icv,ia,,,,,60,,.22.1B2,(reserpine),(propranolol),(metoprolol),(haloperidol),(phentolamine).,,(isoprenaline,Iso)DA(),(phenyle2phrine,Phe).Phe,B2DA2.A2,B2,DA2,B2DA2,B2,A2[16-21].,,,cAMP,.,cAMP,IsocAMP,[22].,,IsoDA[23-25].,B2DA2,B2,cAMP,IsoDAB2DA2,.2.2D2B2B210Lgicv,.50LgicvB2,50Lg.,0.05mmolL-1B2,B2.,,(dihydroetorphine,DHE),D22,D252(D2Ala22,D2Leu52enkephalin,DADLE)(etorphine),.DHE,,nor2binaltorphimine(Nor2BNI,J2);DADLE,,D2ICI174864.,L2J2,D2.242ChineseJournalofPharmacologyandToxicology2000Aug;14(4)D2.,D2J2,L2,D2,J2L2.,,D2J2ICI174864Nor2BNI,ICI174864Nor2BNI.,[26-32]D2,B2,.2.3icv10Lg,,,[3].2.4,,,,(superoxidedismutase,SOD),(malondialdehyde,MDA),Allen,,SOD,MDA[33].,[34].2.5[35],iv(lipopolysaccharide,LPS)A(tumornecrosisfactorA,TNF2A),KupfferLPSTNF2A[36].,NOö.33.1iv(LD50)(22522)mgkg-1[2],ipLD50600mgkg-1.iv30mgkg-1,6,24h,A1,A2B,.1.1.3.2iv(5,10,20mgkg-1)1,15d,d16,,,,,,.510mgkg-1,,;20mgkg-1,,,.,iv10-20mgkg-1,,3.2mgkg-1,0.2-0.4mgkg-1,15d,.3.3:21,d5-15ip,d19,,.,,,,.(13.3,40120mgkg-1),(),[37].Ames:TA97,TA100,TA102,0.1,10,100500Lg,,2.Ames[37].:100.(cyclophosphamide,CP).(0.05,0.0750.15mgkg-1)10%,13.13%,(11%).[37].:Heddle.CP30mgkg-116.7,2.4,(60,120,300mgkg-1)2.2,1.2,2.0.PoissonCP,3[37].34220008;14(4):CP40mgkg-1,,40,60,120mgkg-1.ip5d,6,5d,2d,.d14,,,,,.,,CP[38].Ames,,,.,,,.44.1,,,,.,DHE,,L2,[39,40].4.2,icv10Lgiv50mgkg-1,,,,[40].4.35-50mgkg-1ip,,[40].,,,.5ivt1ö2(10.71.5)min,,,,.,[41].6,,,,4,.,,,,,,,.,.,,.,L2,,.,,,,..,,30%.(30%-50%),,(,,).,.,,..,,,,,.[42]..7:[1]HoladayJW,DAmatoRJ,FadenAI.Thyrotropin2releasinghormoneimprovescardiovascularfunctioninexperimentalendotoxicandhemorrhagicshock[J].Science,1981,213(4504):216-218.[2],,,,,,.TRH[J].,1986,2(2):32-33.442ChineseJournalofPharmacologyandToxicology2000Aug;14(4)[3]YanJ,ChenH,LiaoW,LuS.Cardiovascularef2fectsofthyrotropin2releasinghormoneinnormoten2siveandhypotensiverats:roleofrostralventrolater2almedulla[J].CircShock,1992,37(3):253-261.[4],,.[J].,1990,4(4):248-250.[5]ZhengD,ChenHS,HuDY.Cardiovascularmecha2nismofthyrotropin2releasinghormoneagainstexper2imentalhemorrhagicshock[J].CircShock,1992,36(2):169-173.[6],,,,.TRH[J].,1987,4(3):127.[7]HuDY,HeXD,ChenHS,LiaoSH,FanCG,LiL.Effectsofthyrotropin2releasinghormoneoncardio2vascularfunctionindogswithhemorrhagicshock[J].JTongjiMedUniv,1988,8(4):223-228.[8],,,,,.[J].,1988,2(3):172-177.[9],,,,.[J].,1988,5(4):1-4.[10],,,,,.TRH[J].,1991,71(8):438-440.[11]HuDY,ChenHS,LiuLM,LiaoSH,ZhengD,ZhangH,etal.AntishockpropertyofTRHanditsmechanism[J].ChinJTraumatol(Eng),1993,9(6):22-27.[12],,,,,,.TRH[J].,1999,21(2):146-147.[13],,,.[J].,1995,9(4):307-308.[14],,,,.[J].,1998,20(5):4012403.[15],,,,.TRHICI174,864[J].,1996,18(4):309-311.[16]LiuLM,ChenHS,HuDY,LuRQ.Thesignifi2canceofadrenoceptorsintheantishockeffectsofTRH:studiesonthesignificanceofA,BandDAre2ceptorsintheantihemorrhagicshocktherapywithTRHinrabbits[J].ChinJTraumatol(Eng),1995,11(1):10-12.[17]LiuLM,ChenHS,HuDY,LuRQ,LiTX.Effectsofthyrotropin2reseasinghormoneonmyocardiala2drenoceptorsanddopaminergicreceptorsfollowinghemorrhagicshockintherat[J].Shock,1995,3(6):430-433.[18]LiuLM,ChenHS,HuDY,LuRQ,LiTX.Thy2rotropinreleasinghormonesensitizationofmyocar2dialadrenoceptorsduringhemorrhagicshockinratsanditsmechanisms[J].SupplementtotheThirdIn2ternationalShockCongress,Shock,1995,4:4.[19],,,.TRH[J].,1995,11(4):400-403.[20],,,,.TRH[J].,1996,12(3):294-297.[21],,,.[J].,1994,10(4):49.[22],,,.TPHcAMP[J].,1993,9(5):280-282.[23]LiuLM,ChenHS,HuDY,LuRQ.Thesignifi2canceofadrenoceptorsintheantishockeffectsofTRH.PartÊ:StudiesontheroleofTRHsensitiza2tionofadrenoceptorsintheantishockeffectsofTRHinratsandguineapigs[J].ChinJTraumatol(Eng),1995,11(5):73-77.[24],,,,,,.[J].,1995,11(5):483-487.[25],,,,,,.[J].,1995,9(3):212-215.[26]LiuLM,ChenHS,HuDY,LuRQ.Thyrotropin2releasinghormoneantagonizestheinhibitoryeffectsofbeta2endorphinoncardiovascularsystem[J].J54220008;14(4)MedCollPLA,1996,11(1):57-60.[27],,,.B2[J].,1994,16(6):402-404.[28],,,.L2,D2,J2[J].,1996,18(5):409-412.[29],,,,.L2,D2,J2[J].,1995,9(4):268-270.[30],,,.TRHD2J2[J].,1996,12(Suppl7):729.[31]LiuLM,ChenHS,HuDY,LuRQ,WuY.Theim2portanceofDandJ2opioidreceptorinthepropertyofTRHagainsthemorrhagicshock[J].Shock,1997,7(1):60-64.[32],,.TRH[J].,1994,16(5):326-328.[33],,,,.TRH[J].,1990,12(6