抗菌药物使用强度计算方法

1抗菌药物使用强度药剂科：贾朝辉2012年8月2学习内容一.相关知识二.抗菌药物使用强度三.具体计算步骤四.实例学习3相关知识来源：WHO在1969年制定了解剖-治疗-化学的药物分类系统（anatomicaltherapeuticchemical，ATC），确定了将限定日剂量（defineddailydose，DDD）作为用药频度分析的单位。1.限定日剂量(DDD)：用于主要治疗目的的成人的药物平均日剂量。4相关知识限定日剂量值(DDD值)：由WHO“药物统计方法合作中心”制定的，网上可以查到。按照WHO推荐的药物限定日剂量计算，同一通用名的药物,剂型不同,DDD值也不同。如：1.阿奇霉素片0.25gDDD值0.3g阿奇霉素注射液0.25gDDD值0.5g2.甲硝唑VB6片0.2gDDD值2.0g甲硝唑注射剂0.5gDDD值1.5g5我院抗菌药物5月DDD数品种规格系数使用数量使用总量（g）DDD值(g)DDD数红霉素肠溶片0.125gX100片/瓶12.50010注射用乳糖酸红霉素0.25g/支0.25112.7512.75阿奇霉素分散片0.25gx6片/盒1.5000.30盐酸阿奇霉素注射液0.25g/支0.253280.516注射用阿奇霉素磷酸二氢钠0.25g/支0.25235.750.511.5诺氟沙星胶囊0.1gX10粒/板1110.81.25诺氟沙星葡萄糖注射液100ml：0.2g/瓶0.2000.40乳酸左氧氟沙星分散片0.2gX12片/盒2.4000.50盐酸左氧氟沙星氯化钠注射液100ml:0.5g/瓶0.517185.50.5171甲磺酸左氧氟沙星注射液100ml:0.2g/瓶0.218236.40.572.8注射用青霉素G钠80万U/支0.48640307.23.685.333336我院抗菌药物5月DDD数注射用青霉素G钠160万U/支003.60注射用氨苄西林0.5g/支0.50020注射用氨苄西林/舒巴坦钠3.0g/支30020注射用美洛西林2.0g/支2129258643注射用美洛西林3.0g/支359177629.5注射用美洛西林/舒巴坦钠1.25g/支(1.0:0.25)13163167.542.13333注射用阿莫西林/舒巴坦钠0.75g/支0.750030阿莫西林胶囊0.25gX20/盒51050150阿莫西林/克拉维酸钾分散片228.5mgX12/盒(0.2:0.0285)2.41843.2143.2阿莫西林/克拉维酸钾颗粒228.5mgX6/盒(0.2:0.0285)1.21214.4114.4注射用阿莫西林/克拉维酸钾0.6g/支(0.5:0.1)0.5959479.53159.8333注射用哌拉西林钠0.5g/支0.5001407我院抗菌药物5月DDD数注射用哌拉西林钠/他唑巴坦2.25g/支(2:0.25)4.5474213314152.3571注射用磺苄西林钠1.0g/支17979155.266667注射用头孢噻吩钠0.5g/支0.5510255463.75注射用头孢替唑钠0.75g/支0.75494370.5661.75注射用头孢替唑钠0.5g/支0.51073536.5689.41667注射用头孢唑啉钠0.5g/支0.512486243208注射用头孢硫脒钠1.0g/支1118118339.33333头孢丙烯胶囊0.25gx6粒/盒1.50010头孢丙烯颗粒剂0.125gx6包/盒0.750010注射用盐酸头孢替安钠1.0g/支17447444186注射用头孢孟多酯钠0.5g/支0.5936468678注射用头孢孟多酯钠1.0g/支1206206634.333338我院抗菌药物5月DDD数头孢呋辛酯钠片0.25gx6片/盒1.526390.578注射用头孢呋辛钠0.75g/支0.758766573219注射用头孢呋辛钠1.5g/支1.5577865.53288.5注射用盐酸头孢甲肟0.5g/支0.57063532176.5注射用头孢噻肟钠2.0g/支2140280470注射用头孢哌酮钠/舒巴坦钠1.5g/支(1:0.5)16636634165.75注射用头孢曲松钠1.0g/支1121121260.5注射用头孢他啶1.0g/支1303047.5注射用头孢西丁钠0.5g/支0.516848426140.3333硫酸庆大霉素注射液8万：2ml/支0.0854243.360.24180.6667硫酸庆大霉素缓释片40mgx36片/盒0.0410.040.440.090909注射用硫酸链霉素1.0g/支128281289我院抗菌药物5月DDD数氯霉素注射液0.25g:2ml/支0.250030氯霉素片0.25gx100片/瓶0.250030注射用克林霉素磷酸酯0.5g/支0.517587.51.848.61111注射用亚胺培喃/西司他丁1.0g/支(0.5:0.5)0.510251225.5注射用氨曲南0.5g/支0.514472418伏立康唑片50mgx4片/盒0.2499.80.424.5注射用伏立康唑50mg/支0.05000.40复方磺胺甲噁唑片0.48gx100片/瓶0.4812057.66.089.473684甲硝唑VB6片0.2gx45片/盒90020甲硝唑片0.2gx100片/瓶0.2549109.81.573.2甲硝唑葡萄糖注射液250ml：0.5g/瓶0.5001.50注射用甲硝唑磷酸二钠0.915g/支0.91598.2351.55.49注射用盐酸万古霉素0.5g/支0.598491.630.625合计3311.14810我院抗菌药物6月DDD数品种规格系数使用数量销售总量（g）DDD值(g)DDD数红霉素肠溶片0.125gX100片/瓶12.50010注射用乳糖酸红霉素0.25g/支0.25358.7518.75阿奇霉素分散片0.25gx6片/盒1.5000.30盐酸阿奇霉素注射液0.25g/支0.2520.50.51注射用阿奇霉素磷酸二氢钠0.25g/支0.257819.50.539诺氟沙星胶囊0.1gX10粒/板1110.81.25诺氟沙星葡萄糖注射液100ml：0.2g/瓶0.2000.40乳酸左氧氟沙星分散片0.2gX12片/盒2.4000.50盐酸左氧氟沙星氯化钠注射液100ml:0.5g/瓶0.52361180.5236甲磺酸左氧氟沙星注射液100ml:0.2g/瓶0.217835.60.571.2注射用青霉素G钠80万U/支0.48702336.963.693.611我院抗菌药物6月DDD数注射用青霉素G钠160万U/支003.60注射用氨苄西林0.5g/支0.50020注射用氨苄西林/舒巴坦钠3.0g/支30020注射用美洛西林2.0g/支253106617.66667注射用美洛西林3.0g/支3123666注射用美洛西林/舒巴坦钠1.25g/支(1.0:0.25)13903907.552注射用阿莫西林/舒巴坦钠0.75g/支0.750030阿莫西林胶囊0.25gX20/盒50010阿莫西林/克拉维酸钾分散片228.5mgX12/盒(0.2:0.0285)2.4716.8116.8阿莫西林/克拉维酸钾颗粒228.5mgX6/盒(0.2:0.0285)1.25616注射用阿莫西林/克拉维酸钾0.6g/支(0.5:0.1)0.5843421.53140.5注射用哌拉西林钠0.5g/支0.50014012我院抗菌药物6月DDD数注射用哌拉西林钠/他唑巴坦2.25g/支(2:0.25)4.5790355514253.9286注射用磺苄西林钠1.0g/支14242152.8注射用头孢噻吩钠0.5g/支0.5377188.5447.125注射用头孢替唑钠0.75g/支0.75352264644注射用头孢替唑钠0.5g/支0.51647823.56137.25注射用头孢唑啉钠0.5g/支0.51075537.53179.1667注射用头孢硫脒钠1.0g/支19898332.66667头孢丙烯胶囊0.25gx6粒/盒1.50010头孢丙烯颗粒剂0.125gx6包/盒0.7510.7510.75注射用盐酸头孢替安钠0.5g/支1727363.5490.875注射用头孢孟多酯钠0.5g/支0.52110.561.75注射用头孢孟多酯钠1.0g/支1391391665.1666713我院抗菌药物6月DDD数头孢呋辛酯钠片0.25gx6片/盒1.516240.548注射用头孢呋辛钠0.75g/支0.751138853.53284.5注射用头孢呋辛钠1.5g/支1.57091063.53354.5注射用盐酸头孢甲肟0.5g/支0.510005002250注射用头孢噻肟钠2.0g/支2116232458注射用头孢哌酮钠/舒巴坦钠1.5g/支(1:0.5)16436434160.75注射用头孢曲松钠1.0g/支1190190295注射用头孢他啶1.0g/支1262646.5注射用头孢西丁钠0.5g/支0.513546776112.8333硫酸庆大霉素注射液8万：2ml/支0.0854743.760.24182.3333硫酸庆大霉素缓释片40mgx36片/盒0.0420.080.440.181818注射用硫酸链霉素1.0g/支1272712714我院抗菌药物6月DDD数氯霉素注射液0.25g:2ml/支0.250030氯霉素片0.25gx100片/瓶0.250030注射用克林霉素磷酸酯0.5g/支0.5001.80注射用亚胺培喃/西司他丁1.0g/支(0.5:0.5)0.5301527.5注射用氨曲南0.5g/支0.5208104426伏立康唑片50mgx4片/盒0.2244.80.412注射用伏立康唑50mg/支0.05000.40复方磺胺甲噁唑片0.48gx100片/瓶0.48006.080甲硝唑VB6片0.2gx45片/盒90020甲硝唑片0.2gx100片/瓶0.2564112.81.575.2甲硝唑葡萄糖注射液250ml：0.5g/瓶0.52821411.594注射用甲硝唑磷酸二钠0.915g/支0.91598.2351.55.49注射用盐酸万古霉素0.5g/支0.570351.621.875合计3366.90915我院抗菌药物7月DDD数品种规格系数使用数量销售总量（g）DDD值(g)DDD数红霉素肠溶片0.125gX100片/瓶12.50010注射用乳糖酸红霉素0.25g/支0.254310.75110.75阿奇霉素分散片0.25gx6片/盒1.5000.30盐酸阿奇霉素注射液0.25g/支0.25102.50.55注射用阿奇霉素磷酸二氢钠0.25g/支0.257318.250.536.5诺氟沙星胶囊0.1gX10粒/板1000.80诺氟沙星葡萄糖注射液100ml：0.2g/瓶0.2000.40乳酸左氧氟沙星分散片0.2gX12片/盒2.437.20.514.4盐酸左氧氟沙星氯化钠注射液100ml:0.5g/瓶0.5148740.5148甲磺酸左氧氟沙星注射液100ml:0.2g/瓶0.219138.20.576.4注射用青霉素G钠80万U/支0.48829397.923.6110.533316我院抗菌药物7月DDD数注射用青霉素G钠160万U/支003.60注射用氨苄西林0.5g/支0.50020注射用氨苄西林/舒巴坦钠3.0g/支30020注射用美洛西林2.0g/支24590615注射用美洛西林3.0g/支372163.5注射用美洛西林/舒巴坦钠1.25g/支(1.0:0.25)12232237.529.73333注射用阿莫西林/舒巴坦钠0.75g/支0.750030阿莫西林胶囊0.25gX20/盒5221101110阿莫西林/克拉维酸钾分散片228.5mgX12/盒(0.2:0.0285)2.449.619.6阿莫西林/克拉维酸钾颗粒228.5mgX6/盒(0.2:0.0285)1.20010注射用阿莫西林/克拉维酸钾0.6