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20011147!.1[4]21d～2d2d～3d345!.#1SLE23431d～2d5[5][6]6[7][1]Beck-SagueCJarvisWWR.Seculartrendsintheepi-demiologyofnosocomialfungalinfectionsintheUnitedStates1980～1990[J].JInfectDis19931671247.[2].[J].19988128.[3].130[J].1999142168.[4].[J].199774219.[5].[J].19957297.[6].[J].-1997244145.[7].[M].199739.2000-12-18530027R969.3A2001-01-0047-0216AnalysisofIrrationallyCombinedUseofAntimicrobialsZHOUYanwen(Dept.ofPharmacy,TheFirstAffiliatedHospitalofGuangxiMedicalUniversity,Nanning530027)ABSTRACTOBJECTIVEToanalyzetheirrationalityofcombineduseofantimicrobials.METHODSTocosulttherelevantliteratureandanalyzetheirrationallycombineduseofantimicrobialsthatappearedinout-patientprescriptionsandmedicalrecords.RESULTSTheirrationalityof16kindsofcombineduseofantimicrobialswassummarizedandanalyzed.CONCLUS-IONThereexistedagreatvarietyofirrationallycombineduseofantimicrobialsinclinicalpractice.Itshouldbeavoided.KEYWORDSantimicrobial;combineduse;rationality$+!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!48Evaluationandanalysisofdrug-useinhospitalsofChina2001Vol.1No.1β-[1][2]2FIC1～22GG[3][45]!β-+β-β-+++SMZ++312+3L-L-[6]+1(2)33h～4h+#+[7][8]43AUC98.6%[7]++++22h[9]$+P450N-1～2[10][1011]%+RNADNA[12][13]&++[1213]’+(+11%～26%[1415]75%～90%[16][17])*+TMPTMPTMP[18]303225[19]TMPTMP))50S+++20011149[2021]!SMZco+TMPTMP1:5SMZcoTMP!#+[22][23]SMZco!$+β-β-β-β-[24]β-β-β-!%+β-β-[25]β-!&+[26]14AUC0～2488%[27]Cmax18AUC22[2829]93%AUC52%[24][1].G[J].1995347438.[2].G[J].1997203162.[3].G[J].199429460.[4].2[J].199826654.[5].778[J].199916356.[6].[M].1.199272.[7]JacobusRBJBrouwers.Druginteractionswithquinol-oneantibacterials[J].DrugSafety,1992,7(4)268.[8]NakanoM,yamamotoMAritaT.Interactionsofalu-minum,magnesiumandcalciumionswithnalidixicacid[J].ChemPharmBull,1978,261505.[9].[J].1999245375.[10].[J].198997306.[11].[J].1992172163.[12].[M].13.1992101.[13].[J].199217287.[14].[J].1986254193.[15].[J].1991741.[16].[J].198954220.[17].[J].-1995163233.[18].[J].199111118.[19].[J].1986112126.[20].[J].19932119.[21].1[J].1996113192.[22].[J].199111124.[23].[J].1992172130.[24].Imipeenem/Cilastatin[J].-19885339.[25]./[J].-1994153238.[26]JaruratanasirikulS,SriwiriyajanS.Effectofrifampicinonthepharmacokineticsofitraconazoleinnormalvol-nteersandAIDSpatients[J].EurJClinPharmacol1998,54(2)155.[27]KaltenbachG,LevequeD,PeterJD,etal.Pharmacoki-neticinteractionbetweenitraconazoleandrifampininyucatanminiaturepigs[J].AntimicrobAgentsChemot-her1996,40(9)2043.[28]NicolauPP,CroweHM,NightingaleCH,etal.Rifamp-in-fluconazoleinteractionincriticallyillpatients[J].Ann-Pharmacother1995,29(10)994.[29]ApsloffG,HilligossDM,GardnerMJ,etal.Inductionoffluconazolemetabolismbyrifampininvivostudyinhumans[J].JClinPharmacol1991,31(40358.2001-01-09