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3512()Vol.35No.12200712JournalofNorthwestA&FUniversity(Nat.Sci.Ed.)Dec.200731,1,1,2(1,712100;2,510225)[],,,[];;;[]S789.4[]A[]167129387(2007)1220081206ReviewofmedicinalfunctionofpersimmonleavesandtheirdevelopmentandutilizationZHENGHao1,LUZhou2min1,LIUYue2mei1,BAIWei2dong2(1CollegeofForestry,NorthwestA&FUniversity,Yangling,Shaanxi712100,China;2CollegeofLightIndustryandFood,ZhongkaiCollegeofAgricultureandTechnology,Guangzhou,Guangdong510225,China)Abstract:Tofurtherdevelopandutilizeplentifulresourcesofpersimmon(DiospyroskakiL.f.)leafwhichcontainsabundantnutrientandefficacycomponentsinChina,asurveyofresearchonthemedicinalfunction,clinicalapplication,developmentandutilizationofpersimmonleavesintheworldwerecompre2hensivelyintroduced.Anditsindicatedthatstudyinfutureshouldbecentredontherelationshipbetweenactiveprincipleandmedicinalfunctionandtheexploitationoffunctionalhealthprotectionproductsofper2simmonleaf.Keywords:persimmonleaves;medicinalfunction;clinicalapplication;developmentandutilization(Ebenaceae)(Diospyros)(DiospyroskakiL.f.),[1]VC,100g11.05g,6.84g,54.84mg,VC704mg,317mg,121.34mg,Vc,[2],,11.1[3]32O22D2323[]2006212220[](2005Z32E0031)[](1984-),,,,[](1967-),,,,,O22L2322D232O22L2(232)[4]1.219219,242[526]1.362272[7]1.4B2[6]1.5[8]GC2MS21,19,98.72%,11,70.78%,(30.00%)(19.01%)(10.42%)(6.68%)(1.72%);8,27.93%,2(22.22%)(1.84%)(1.44%)(1.25%)(),1.6VC[9][10]VC,VC(P0.01),5[11]2,,()2.178.3%,49.3%;,75.1%;[12214],,30%40%,35%40%33%36%[15];,,,[13],,,,[16];,[17][18],45Wistar32,,(advancedglyca2tionEndproducts,AGEs),AGEs,,,,[19],AGEs[19],AGEs,[20](ad2vancedoxidationproteinproducts,AOPP),[21]AOPP(AGEs),AGEsAOPP[20,22];,AOPP,AOPP[23]Han[24],;Chen[25],5,,AGEsAOPP[20,22][20,22],AGEsAOPP28()35,[19]2.244.7%,34.3%,4d62.5%,70%(P0.05)[15],80%,[6][15]4(41),[26],[27]2.3Wistar2,(),LPO()SOD(),[18][28229]An[30],,,(OH),OH(MDA),,[31];Han[24],,,,[24]2.4,,,[15][32]7(),,,2.5[33],,4610,30,6,1[1]2.6,(SRBC);(GVH)A(Conconvalina,ConA),,[34]2.730d,[35]2.8(NC/Ngamice),,,IgE,,[36]250mg/kg1.5mg/kg,,[37]2.9[38][39],,;VC,,[11],[40],81,91%[38];247,68%[40],(),3812:32,[40]2.103,[41][42][43245],[46]3,,,3.1,[47],,,,[48]:(0.51.0cm)3.1.1,79,,,,[49],,,,;[50],,6103.1.2,,,,,3.1.370802min,pH735h,11.5h,3.1.4,,,,,,,,,,,,[51]3.1.5,,,3.1.6,6,Vc;6,Vc81.1%[52],[48],[53],[54],[55],3.2[56]:3.2.1[57],10015s,2538,,3.2.25,1220min,,2,3,3Vc,0.5%1.0%,pH6.06.5[57],,3648h,[51]3.2.3,[57]():35%,10%,48()350.10%,0.15%,0.30%,1.0%,0.05%3.2.47080,1211520min3.2.5:100/mL,60/L,3.3,,[58],:1kg,1.5kg,():3.4,,[59],,(0.01%2%)[60]3.5,,(),,,,,[][1],,.[J].,1995,10(6):24,33.[2].[J].,2001(11):27228.[3]NakataniM,MiyazakiY,IwashitaT,etal.TriterpenesfromI2lexrotundafruits[J].Photochemistry,1989,28(5):147921482.[4]GorobetsAV.AntibacterialcompoundsfromOakquercusacu2tathumb[J].KhimPrirSoedin,1985(5):710.[5]MatsuraS,IinumaM.Studiesontheconstituentsofusefulplants.IV:TheconstituentsofcalyxofDiospyroskaki[J].YakugakuZasshi,1977,97(4):4522455.[6]FunayamaS.Studyonextractionandisolationofpersimmonflavoneglucosides[J].ChemPharmBull,1979,27:286522869.[7],,,.[J].,2006,26(4):87290.[8],.GC2MS[J].,2000,19(1):74275.[9]KusunokiK,HaraT,FujitaM,etal.Histochemicalobserva2tionandcellulardistributionofascorbicacidinpersimmonleaves[J].JournalofNutritionalScienceandVitaminology,1998,44(1):11223.[10],,,.[J].,2005,21(2):1992201.[11]ClarkCJ,SmithGS.Seasonalchangesinthemineralnutrientcontentofpersimmonleaves[J].ScientiaHorticulturae,1990,42(12):85297.[12],,.[J].,1983(7):27229.[13],,,.[J].,1983(5):430.[14],,,.[J].,1983,5(2):72.[15],,.[J].,2007,35(2):49251.[16],,.[J].,2004,21(3):39241.[17],,,.[J].,2004,11(7):5912592.[18],.[J].,1998(11):39240.[19],,,.[J].,2003,23(7):6802682.[20],,,.[J].,2003,23(12):126021262.[21]KalousovaM.Advancedglycationendproductsandadvancedoxidationproteinproductsinpatientswithdiabetesmellitus[J].PhysiolRes,2002,51:597.[22],,,.[J].,2004,27(3):1862188.[23]DruekeT.Irontherapy,advancedoxidationproteinproducts,andcarotidarteryintimaemediathicknessinendstagerenaldisease[J].Circulation,2002,106:2212.[24]HanJ,KangS,ChoueR,etal.FreeradicalscavengingeffectofDiospyroskakiandUndariapinnatifida[J].Fitoterapia,2002,73(78):7102712.[25]ChenG,LuH,WangC,etal.Effectoffivetriterpenoidcom2poundsisolatedfromleavesofDiospyroskakionStimulus2in2ducedsuperoxidegenerationandtyrosylphosphorylationinhumanpolymorphnuclearleukocytes[J].ClinChimActa,2002,320(12):11216.5812:[26],.[J].,2005,27(1):66267.[27],,,.[J].,2005,31(7):91294.[28].[J].,2004,25(1):10.[29],,.[J].,2006(12):67270.[30]AnBJ,BaeMJ,ChoiHJ,etal.Isolationofpolyphenolcom2poundsfromtheleavesofKoreanpersimmon(DiospyroskakiL.Folium)[J].AgricultureChemistryandBiotechnology,2002,45(4):2122217.[31],,.[J].,2003,15(3):43244.[32],,.[J].,2003,24(3):1292131.[33].[J].,2003(6):35236.[34],,.DK2N3[J].,1987,9(3):125.[35]ShinjiUC,HisashiO,MasamiN.ProlongationoflifespanofStroke2pronespontaneouslyhypertensiverats(SHRSP)in2gestingpersimmontarnin[J].ChemPharmBull,1990,38(4):104921052.[36]KotaniM,MatsumotoM,FujitaA,etal.Persimmonleafex2tractandastragalininhibitdevelopmentofdermatitisandIgEelevationinNC/Ngami