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目录[摘要].................................................................................................................................1[关键词]................................................................................................................................1第一章综述部分..............................................................................................................21.1引言............................................................................................................................................21.2席夫碱的合成及应用概况.........................................................................................................21.2.1席夫碱化合物在发光材料领域的应用..........................................................................21.2.2席夫碱化合物在医药领域的应用..................................................................................31.2.3席夫碱化合物在催化领域的应用..................................................................................41.3新型氨基酚席夫碱的合成及研究.............................................................................................4第二章新型氨基酚席夫碱的合成及其DPPH自由基清除能力的研究........................7引言...................................................................................................................................................71实验部分.....................................................................................................................................71.1主要仪器与试剂..............................................................................................................71.2合成路线.............................................................................................................................81.3实验步骤.............................................................................................................................81.4DPPH自由基清除活性测试...............................................................................................82结果与讨论...................................................................................................................................92.1合成物的表征数据.............................................................................................................92.2化合物1、2对DPPH自由基的清除活性........................................................................9第三章新型氨基酚席夫碱对金属离子及DNA的螯合研究.........................................12引言.................................................................................................................................................121实验部分.....................................................................................................................................121.1材料与仪器设备..............................................................................................................121.2化合物1、2与金属离子和DNA的识别作用.................................................................122结果与讨论.................................................................................................................................133结论.............................................................................................................................................15致谢.............................................................................................................................17声明...............................................................................................................................18桂林师范高等专科学校1新型氨基酚席夫碱的合成及性能研究路环08生化制药技术2班指导教师张业[摘要]席夫碱及其金属配合物，长期以来成为研究热点，主要源自它们所含C=N基团的功能性、与中心离子的多齿酰胺、Schiff碱两类配体的金属配合物，由于它们与生物体的直接关系及特殊的化学性质，很早就引起人们的极大兴趣。席夫碱类化合物在药学、催化、分析化学、防腐蚀以及光致变色领域都有重要的应用。多种研究表明席夫碱结构具有重要的生物学意义。本文基于生物电子等排体原理，对人体必需的一种脂溶性维生素A抗氧化剂进行结构重新设计与改造，以两种氨基酚为原料，与N,N-二甲基-4-氨基苯甲醛合成了2个席夫碱，通过H谱、质谱对其进行表征，并在对DPPH自由基清除活性研究的基础上，用荧光猝灭法研究了这两个化合物与Fe2+、Fe3+、Cu2+及DNA的螯合作用。[关键词]席夫碱；自由基；合成；螯合作用AbstractSchiffbaseanditsmetalcomplexes,haslongbeenaresearchfocus,mainlyfromC=Ntheycontainfunctionalgroups,andthecentralionofmulti-toothamide,Schiffbaseligandsoftwotypesofmetalcomplexes,duetotheirdirectrelationshipwiththeorganismsandthespecialchemicalproperties,havelongarousedgreatinterest.Schiffbasecompoundsinmedicine,catalysis,analyticalchemistry,corrosionprotectionandphotochromicfieldshaveimportantapplications.MingXifubasestructureofthetableavarietyofimportantbiologicalsignificance.Basedontheprincipleofbio-electronics,andotherexclusivebodyofafat-solublevitaminessentialantioxidantsAstructuralre-designandtransformation,intwoaminophenolasrawmaterials,andsyntheticaminobenzaldehydeSchiffbaseof2,bymeasuringthemeltingpoint,HNMR,MSitscharacterization,andintheDPPHfreeradicalscavengingactivity,basedon,andthenfluorescencequenchingofthistwocompoundswithFe2+,Fe3+,Cu2+andtheDNAofthesequestration.KeywordsSchiffbase;freeradical;synthesis;chelation桂林师范高等专科学校2第一章综述部分1.1引言席夫碱是含有亚氨基（C=N-）的一类化合物。Schiff在1864年首先用水杨醛、苯胺和铜离子合成，席夫碱（Schiffbase）也因此得名。席夫碱可以由伯胺与活泼羰基化合物在碱性条件下缩合制得，生成具有亚胺结构的产物R1R2C=NR3（R1、R2、R3分别为H、烷基、环己基、芳香基或杂环），其特点是能够灵活地选择反应物，改变取代基给予体原子本性及其位置，便于开拓出许多从链状到环合，从单齿到多齿的性能各异、结构多变的席夫碱配体，如单齿希夫碱、双齿希夫碱、不对称希夫碱、异双希夫碱、大环席夫碱等。席夫碱可用作过渡金属离子配合物的配体