生物技术在手性药物合成中的应用

20027132060thalidomicS-R-20906.62000200029.52019LD100LD2100120-30100SynopsysBiocalalysis199550001996415000323CNSPH2O808631986210199611410501990274361998315261780126222530111472217122127351305202185021809011010010.71008020199466.671997116.8716%140021%--22%199729:34:372/3,WTO198910α1brhuIFNα1b19891996α1brhuIFNα1bHBVHCV19961996199719971997α2arhuIFNα2aHBVHCV19971996199719971997α2brhuIFNα2bHBVHCV199719941995rhuIFN19951997199719971997199719971995-2rhuIL-21995rhuG-CSF1996rhuGM-CSF1997rSK1996rhuEPO1997EPOα-bFGF1996rhuEGF()1997NGF(II)IIIIIICNTFGDNFBDNFSODLEPTINIGF-1hGHCIL-6Flt3bFGF967182.5Sa2b-11a-22b2(125Ser)HIV1+2P53(SBN-1)3(131I)IgM-2T-2125AlaCD3AC1991BHSV-TK101992CT908631%cDNADNA2001994GeneChipDNAChipDNAMicroarray18000cDNASPGC-200DNAEIAPCR25300PCRP531♣2003♣♣SNPs♣♣♣♣♣♣♣♣♣♣9080909011.832WTO12III2001199740001999GMPPCRPCR70%31994JACKSONIMR4DNA60%~70%3901990198814FDA198880198419868631988199661997819985()201123412PHB1234512341100m2300m2213020024034122.5510303002123123451sinopak-s231234512123412331pHFETH+-222%11%50%2021201271994212121(1)(2)(3)(4)6DNADNAGMPGMP300260043[1]2001.5P275-284[2]2001.9P32-46