搜索
,,(,,400061):;;:R964:A:1005-8559(2001)04-0384-02,,,,,,,,,(DA)5(5-HT)(NA),,,DA,,DA,,,1.(DA)D1(D1D5)D2(D2D3D4),DA(1)D1NacD1[1],D1,D1,WeeDWoolvertonSKF38393SKF77434,SKF81297SKF82958[2]D5,,(2)D2D2,D1D2bromocriptine,,[3],D2D2,,,,,[4],D2,,[5]2.(DAT)DA[6],,DA,DA3.(Mazindol)DA(NA),,[7]DA,,,,(SPECT),DA25%,4.(Bupropion),,,,[8]5.DAT,,--DAT,5[9]6.G(GBR)GBR,[10],,,,,4,4-,DAT5-HT7.DAT,,GBR2-,2-,S-(+)DAT,4,4-,4,4-483ChineseJournalofBehavioralMedicalScience10(4),2001[11]8.,,,,[12]9.,,,,NMDADAT5-HT,[13],,DA,,,-,,:(1);(2);(3);(4),,,[][1]MooreRJ,VinsantSL,NaderMA,etal.Effectofcocaineself-administrationonstriataldopamineD1receptorsinrhesusmon-keys[J].Synapse,1998,28(1):19.[2]WeedMR,WoolvertonWL.ThereinforcingeffectsofdopamineD1receptoragonistsinrhesusmonkeys[J].JPharmacolExpTher,1995,275(3):13671374.[3]TennantFS,SagherianeAA.Doubleblindcomparisonofamanta-dineandbromocriptineforambulatorywithdrawalfromcocainedependence[J].ArchInternMed,1987,147(1):109112.[4]LeducPA,MittlemanG.Interactionsbetweenchronichaloperi-doltreatmentandcocaineinrats:ananimalmodelofintermittentcocaineuseinneuroleptictreatedpopulations[J].Psychopharma-cology,1993,110(4):427436.[5]OhuohaDC,MaxwellJA,ThomsonLE.Effectofdoparminere-ceptorantagonistsoncocainesubjectiveeffects:auaturalisticcasestudy[J].JSubstAbuseTreat,1997,14(3)249258.[6]MissaleC,CastellettiL,GoroniS,etal.Dopamineuptakeisdif-ferentiallyregulatedinratstriatumandnudeusaccumbens[J].JNeurochem,1985,45(1):5156.[7]RothmanRB.Highaffinitydopaminereuptakeinhibitorsaspo-tentialcocaineantagonists:astrategyfordrugdevelopment[J].LifeSci,1990,46(20):1721.[8]MargolinA,KostenT,PetrakisL.Bupropionreducescocaineabuseinmethadonemaintainedpatients[J].ArchGenPsychia-try,1991,48(1):87.[9]DeutschHM,ShiQ,GruszeckaKonalikE,etal.Synthesisandpharmacologyofpotentialcocaineantagonists.2.Substitutedmethyphenidateanalogues[J].JMedChem,1996,39(6):12011209.[10]MateckaD,RothmanRB,RadescaL,etal.Developmentofnov-el,potent,andselectivedopaminereuptakeinhibitorsthroughal-terationofthepiperazineringof1-[2-(diphenylmethoxy)ethy]and1-[2-bis(4-fluonophenyl)methoxy]ethyl]-4-((3-phenyl-propyl)piperazines(GBR12935andGBR12909)[J].JMedChem,1996,39(24):47044716.[11]NewmanAH,AllenAC,IzenuasserS,etal.Novel3alpha(diphenylmebhoxy)tropaneanalogues:potentdopamineuptakeinhibitorswithoutcocaine-likebehavioralprofiles[J].JMedChem,1994,37(15):22582263.[12]CarrollFI,LewinAH,BojaJW,etal.Cocainereceptorbio-chemicalcharacterizationandstructure-activityrelationshipsofco-caineanaloguesatthedopaminetransporter[J].JMedChem,1992,35(6):969981.[13]MadrasBK,JonesAG,MahmoadA,etal.Technepine:ahigh-affinity99m-technetiumprobtolabelthedopaminetransporterinbrainbySPECTimaging[J].Synapse,1996,22(3):239246.:(1965-),,,,:2001-02-26:(372);,EA,;,R2=0.509,EA50.9%,EASCL-90,,,,,[][1].[J].,1996,3:170.[2].[J].,1983,15:186190.[3].(SCL-90).,1984,4(2):6768.[4],.[J].,1990,4(6):262267.[5].(SSRS)[J].,1993,:4246.[6].16[M].,1987.[7],.Olson[J].,1993,7():193.:(1971-),,,,:2001-04-16:5832001104