硕士论文-基于细胞水平的抗骨质疏松中药药效学评价方法的建立

浙江大学硕士学位论文基于细胞水平的抗骨质疏松中药药效学评价方法的建立姓名：毛翠平申请学位级别：硕士专业：生物医学工程指导教师：郑筱祥;严伟民20060501基于细胞水平的抗骨质疏松中药药效学评价方法的建立作者：毛翠平学位授予单位：浙江大学参考文献(138条)1.参考文献2.Whatyoushouldknowaboutcalcium20053.AtkinsGJ.BouralexisS.HaynesDROsteoprotegerininhibitsosteoclastformationandboneresorbingactivityingiantcellstumorsofbone2001(04)4.BrightonCTTreatmentofsciaticdenervationdisuseosteoporosisintherattibiawithcapacitivclycoupledelectricalstimulation.Doseresponseanddutycycle1985(07)5.BurrDB.ForwoodMR.FyhrieDPBonemicrodamageandskeletalfragilityinosteoporoticandstressfractures1997(01)6.CelikerR.ArslanSComparisonofseruminsulin-likegrowthfactor-1andgrowthhormonelevelsinosteoporoticandnon-osteoporoticpost-menopausalwomen2000(06)7.CentrellaM.HorowitzMC.WozneyNMTransforminggrowthfactor-βgenefamilymembersandbone1994(01)8.ChambersTJRegulationofthedifferentiationandfunctionofosteoclast2000(01)9.Fastfactsonosteoporosis200510.FrattiniA.OrchardPJ.SobacciCDefectsinTCIRG1subunitofthevacuolarprotonpumpareresponsibleforasubsetofhumanautosomalrecessiveosteopetrosis200011.GengeBR.SauerGR.WuLNCorrelationbetweenlossofalkalinephosphatasezctivityandaccumulationofcalciumduringmatrixvesiclemediatedmineralization1988(34)12.GoriF.HofbauerLC.DunstanCRTheexpressionofosteoprotegrinandthesupportofosteoclastformationbystromal-osteoblastlineagecellisdevelopmentalyregulated2000(123)13.HankeyDD.MccabeRE.DohertyMJEnhancementofhumanosteoblastproliferationandphenotypicexpressionwhenculturedinhumanserum2001(04)14.HillNL.LaibAMutationoftheectodysplasin-Ageneresulesoninnoneeffectsinmice2002(2-3)15.HodgkinsonA.AaronJE.HorsmanAEffectofoophorectomyandcalciumdeprivationonbonemassintherat1978(04)16.IidaS.IidaAImprovementofmultiplepathophysiologicalphenotypesofklothomicebyadenovirus-mediatedexpressionoftheklothogene2000(04)17.Importanceofexerciseforbonehealth200518.IwamaH.AmagayaS.OgiharaYEffectofshosaikotoaJapaneseandChinesetraditionalherbalmedicalmixtureonthemitogenticactivityoflipopolysaccharid:anewpharmacologicaltestingmodel1987(01)19.JacquesPBrown.RobertGJosseclinicalpracticeguidelinesforthediagnosisandmanagementofosteoporosisinCanada2002(zk)20.KimmelDBAnimalmodelsinosteoporosisresearch200221.LinKhautTAGrowthfactorsforbonegrowthandrepair:IGF、TGF-βandBMP1996(zk)22.LukertBP.RaiszLGGlucocorticoid-inducedosteoporosis,pathogenesisandmanagement1990(05)23.MarieHLThemethodstogeneratetransgenicanimalsandtocontroltransgeneexpression2002(2-3)24.MasatoNagashima.AkinoiSakai.SoshiUchidaBisphosphonate(YM529)delaystherepairofcorticalbonedefectafterdrill-holeinjurybyreducingterminaldifferentiationofosteoblastsinthemousefemur2005(03)25.MeltonLJHowmanywomenhaveosteoporosisnow?1995(02)26.MichigamiT.Thara-WatanabeM.YamazakMReceptoractivatorofnuclearfactorKappaBligand(RANKL)isakeymoleculeofosteoclastformationforbonemetastasisinanewlydevelopedmodelofhumanneuroblastoma2001(04)27.MinkinCBoneacidphosphatase:Tartrate-resistantacidphosphataseasamarkerofosteoclastfunction1982(03)28.MurakamiH.TakahashiN.SasakiTApossiblemechanismofthespecificactionofbisphosphonatesonosteoclasts:Tiludronatepreferentiallyaffectspolarizedosteoclastshavingruffledborders1995(02)29.NelsonRL.TurykM.KimJBonemineraldensityandthesubsequentriskofcancerintheNHANESIfollow-upcohort2002(01)30.NishikawaM.AkatsuT.KatayamaYBisphosphonatesactonosteoblasticcellsandinhibitosteoclastformationinmousemarrowcultures1996(01)31.OchiK.ChenG.UshidaTUseofisolatedmatureosteoblastinabundanceactsasdesired-shapedboneregenerationincombinationwithamodifiedPoly-DL-Iactic-co-glycolicacid-collgensponge2003(01)32.PadittAM.VillanuevaAR.FoldesJRelationsbetweenhistologicindicesofboneformation:implicationsforthePathogenesisofspinalosteoporosis1995(03)33.PedersonL.KremerMEvidenceofacorrelationofestrogenreceptorlevelandavianosteoclastestrogenresponsiveness199734.ReportofaWHOStudyGroupAssessmentofFractureRiskandItsApplicationtoScreeningforPostmenopausalOsteoporosis:SynopsisofaWHOreport1994(06)35.ResveTTargeteddisruptionoftheosteoblast/osteocytefactor45generesultsinincreasedboneformationandbonemass2003(03)36.RiggsBL.LJMeltonOsteoporosis:Etiology,Diagnosis,andManagement199537.SchmidC.EmstMInsulin-likegrowthfactors,Cytokinesandbonemetabolism199238.ShadmenSInterleukin-1hasbiphasiceffectsonboneformationbyratbonemarrowstromalcells199539.ShanghnasySG.WaltonKJ.DeschamspNeutralizationofinterleckin-11activitydecreasesosteoclastformationandincreasecancellousbonevolumeinoreriatemizedmice2002(02)40.SharpeM.SpencerCMEtidronatedisodium:anupdateofitsuseinosteoporosis2001(07)41.ShoshanaYakar.CliffordJRosen.WesleyGBeamerCirculatinglevelsofIGF-1directlyregulatebonegrowthanddensity2002(06)42.SimoneDetre.JanineSalter.DianaMBarnesTime-relatedeffectsofestrogenwithdrawalonproliferationandcelldeath-relatedeventsinMCF-7xenografts1999(02)43.StavrosC.ManolagasBirthanddeathofbonecells:BasicRegulatoryMechanismsandImplicationsforthePathogenesisandTreatmentofOsteoporosis2000(02)44.StevenL.TeitelbaumBoneresorptionbyosteoclasts2000(5484)45.TakahashiN.YamanaH.YoshikiSHOsteoclast-likecellformationanditsregulationby