浙江大学硕士学位论文芬太尼颊粘膜给药系统的研究姓名:施菁申请学位级别:硕士专业:药物制剂指导教师:金一;邱利焱20050512芬太尼颊粘膜给药系统的研究作者:施菁学位授予单位:浙江大学参考文献(36条)1.HoogstraateJAJ.WertzPWDrugdeliveryviathebuccalmucosa1998(07)2.SenelS.KremerMJ.KasS.WertzP.W.,HincalA.A.,SquierCAEnhancingeffectofchitosanonpeptidedrugdeliveryacrossbuccalmucosa2000(03)3.倪丹.陆彬口腔、鼻腔与直肠给药新剂型见:药物新剂型与新技术19984.WertzPW.HoogstraateJAJ.SquierCABiochemicalbasisofthepermeabilitybarrierinskinandoralmucosa19965.JamesB.StreisandMDBuccalAbsorptionofFentanylIspH-DependentinDogs1995(03)6.DucheneD.TonchardF.PeppasNAPharmaceuticalandmedicalaspectsofbioadhesivesystemsfordrugadministration1988(04)7.AhujaA.KharRK.AliJMucoadhesivedrugdeliverysystem1997(09)8.ChoiHG.KimCKDevelopmentofomeprazolebuccaladhesivetabletswithstabilityenhancementinhumansaliva2000(03)9.MiyazakiS.NakayamaADrugreleasefromoralmucosaladhesivetabletsofchitosanandsodiumalginate1995(02)10.ShojaeiAH.PaulsonJ.HonarySEvaluationofpoly(acrylicacid-co-ethylhexylacrylate)filmsformucoadhesivetransbuccaldrugdelivery:factorsaffectingtheforceofmucoadhesion2000(2-3)11.MortazaviSAAninvitroassessmentofmucus/mucoadhesiveinteractions1995(02)12.吴琼珠.戴永健.乔善磊非洛地平口腔粘附片的研究2001(01)13.AshwinkumarCJ.BruceJ.AungstMoji.ChristianahAdeyeyeDevelopmentandInVivoEvaluationofBuccalTabletsPreparedUsingDanazol-Sulfobutylether7β-Cyclodextrin(SBE7)Complexes2003(07)14.LeeY.ChienYWOralmucosacontrolleddeliveryofLHRHbybilayermucoadhesivepolymersystems1995(03)15.ParkCR.MundayDLDevelopmentandevaluationofabiphasicbuccaladhesivetabletfornicotinereplacementtherapy2002(1-2)16.ZhangJJ.TuXDTheEffectofInterpolymerComplexFormationontheReleaseofBuccoadhesiveTablets2000(04)17.SenelS.HincalAADrugpermeationenhancementviabuccalroute:possibilitiesandlimitations2001(1-3)18.SenelS.DucheneD.HincalAAInvitrostudiesonenhancingeffectofsodiumglycocholateontransbuccalpermeationofmorphinehydrochloride1998(2-3)19.HoogstraateAJIn-VivoBuccalDeliveryofFluoresceinIsothiocyanate-Dextran4400withGlycodeoxycholateasanAbsorptionEnhancerinPigs1996(05)20.ArtusiM.SantiP.ColomboPBuccaldeliveryofthiocolchicoside:invitroandinvivopermeationstudies2003(01)21.AmeyeD.VoorspoelsJExvivobioadhesionandinvivotestosteronebioavailabilitystudyofdifferentbioadhesiveformulationsbasedonstarch-g-poly(acrylicacid)copolymersandstarch/poly(acrylicacid)mixtures2002(1-3)22.NikolaosAPeppas.JenniferJSahlinHydrogelsasmucoadhesiveandbioadhesivematerials:areview1996(16)23.Remunan-LopezC.PorteroA.Vila-JatoJLDesignandevaluationofchitosan/ethylcellulosemucoadhesivebilayereddevicesforbuccaldrugdelivery1998(2-3)24.ParkCR.MundayDLMundayDevelopmentandevaluationofabiphasicbuccaladhesivetabletfornicotinereplacementtherapy2002(1-2)25.陈夏景.王浩芬太尼口腔粘附片的处方研究1997(03)26.KhannaR.AgarwalSP.AhujaAPreparationandevaluationofbioerodiblebuccaltabletscontainingclotrimazole1996(01)27.AlurHH.PatherSI.MitraAKTransmucosalsustained-deliveryofchlorpheniraminemaleateinrabbitsusinganovel,naturalmucoadhesivegumasanexcipientinbuccaltablets1999(01)28.MumtazAM.Ch'ngHSEvaluationofbioadhesivebuccaltabletscontainingriamcinoloneacetonideinhealthyvolunteers1995(02)29.EggerthRMEvaluationofhamstercheekpouchasamodelforbuccalabsorption1987(01)30.杨鹏晖.袁和亮.史晖米非司酮阴道贴膜的研究1994(05)31.TsutsumiK.ObataY.TakayamaKPermeationofseveraldrugsthroughkeratinizedepithelial-freemembraneofhamstercheekpouch1999(01)32.VyasK.KellawayIWInvitrodiffusionofthyrotrophinreleasinghormonecrossporcinebuccalmucosa1994(04)33.JastiBR.ZhouS.MehtaRCPermeabilityofantisenseoligonucleotidethroughporcinebuccalmucosa2000(1-2)34.CornazGudetAL.Ganem-quintanarAF.BuriPSimplemethodofinvitrodiffusionofnicotineacrossporcinepalatinemucosa1997(03)35.JungingerHE.HoogstraateJA.VerhoefJCRecentadvancesinbuccaldrugdeliveryandabsorption-invitroandinvivostudies1999(1-2)36.TsutsumiK.ObataY.NagaiTBuccalabsorptionofergotaminetartrateusingthebioadhesivetabletsysteminguinea-pigs2002(1-2)相似文献(1条)1.期刊论文施菁.邱利焱.吴超.金一.申屠建中.SHIJing.QIULi-yan.WUChao.JINYi.SHENTUJian-zhong芬太尼双层缓释贴膜的研制及性质评价-中国药学杂志2005,40(16)目的制备芬太尼双层口腔贴膜,并对其进行性能评价.方法以保护层和生物黏附层制备芬太尼双层口腔贴膜,并以贴膜的体外黏附力、体内黏附时间、释药行为及离体颊膜渗透能力等为指标,对贴膜的处方进行筛选.结果海藻酸钠与羧甲基纤维素钠及聚乙烯醇以2:1:2的比例制成的膜剂为最佳处方,其体外黏附力为(203±21)g·cm-2,口腔黏附时间为120min,体外释药行为符合Higuchi方程.芬太尼的平均渗透速率为10.527μg·cm-2·h-1,其渗透过程属于零级动力学过程.加入甘草甜素前后,药膜的黏附力稍有下降,体外溶出速度与颊膜渗透速度均增加.结论芬太尼双层口腔贴膜有望成为芬太尼的新型透颊膜给药制剂.本文链接:授权使用:上海海事大学(wflshyxy),授权号:7f5bce92-9ecb-45bf-be34-9dfc00916418下载时间:2010年9月25日