第38章抗肿瘤药

nnnnnnnn1.1.2.2.DNADNARNARNA3.3.cellcyclecellcyclenonspecificagentsnonspecificagentsCCNSACCNSAcellcyclecellcyclespecificagents,specificagents,CCSACCSAgrowthfractiongrowthfractionGFGFGFCCNSACCNSACCSACCSA··DNADNA··DNADNA··RNARNADNADNA······naturalresistancenaturalresistance··acquiredresistanceacquiredresistance··multidrugmultidrugresistanceresistanceMDRMDR····DNADNA…………··PP--glucoproteinglucoproteinPP--ppdrugeffluxpumpdrugeffluxpumpSS1.1.methotrexatemethotrexateMTXMTXFHFH22®®FHFH44®®®®DNADNA®®2.2.fluorouracilfluorouracil55--FUFU55FF--dUMPdUMP®®DNADNA3.3.mercaptopurinemercaptopurine66--MPMPSShydroxycarbamidehydroxycarbamideHUHU®®®®DNADNASSGG115.5.DNADNAcytarabinecytarabineAraAra--CCDNADNADNADNA®®alkylatingalkylatingagentsagents®®DNADNADNADNAcyclophosphamidecyclophosphamideCTXCTXthiotepathiotepaTSPATSPAbusulfanbusulfancarmustinecarmustine2.2.DNADNAcisplatincisplatincarboplatincarboplatinDNADNAmitomycinmitomycinCCDNADNADNADNAbleomycinbleomycinBLMBLM®®®®DNADNA®®DNADNAGG22camptothecinecamptothecineCPTCPTDNADNADNADNAdactinomycindactinomycinDNADNARNARNARNARNAmRNAmRNAdoxorubicindoxorubicinadriamycinadriamycindaunorubicindaunorubicinrubidomycinrubidomycinMMRNARNAGGvinblastinevinblastinevincristinvincristinvindesinevindesine®®®®MMpaclitaxelpaclitaxeltaxoteretaxotere2.2.harringtonineharringtoninehomoharringtoninehomoharringtonineaminoglutethimideAGarsenictrioxideAsTnnnnnnnnnnnnnnnn