第一篇药理学总论药理学总论试题

1A1ABCDE2LD50ABCDE3ED50A50B50C50D50%E504ABCDE55LD50ED50ALD5050mg/kgED5025mg/kgBLD5025mg/kgED505mg/kgCLD5025mg/kgED5015mg/kgDLD5025mg/kgED5010mg/kgELD5025mg/kgED5020mg/kg6ABCDE7ABCDE8ABCDE9T1/224h1A2B3C0.5D5E110T1/2ABCDE11T1/224h2A2dB1dC0.5dD5dE3d12ABCDE13ABCDE14ABCDE15ABCDE16xyABSCDE17LD50ABCDE18ABCDE19ABCDE20pA2ABCDE321pD2pD2ABCDE22ABCDE23pKaA90pHB99pHCpHD50pHEpH24pH790%pKaA7B9C8D5E625pKa3.5pH7.5A0.1B0.01C1D10E9926ABCDE27ABCDE28ABCDE29ABCDE30ABCDE/31ABCP450DE432ABCDE33ABCDE34ABCDE35ABCDE362g100mg/LA0.05LB2LC5LD20LE200L37ABCDE38ABCDE39ABCDE40ABCDE41ABCDE42T1/233h5A2dB3dC5dD7dE4d43T1/2ABCDE44ABED95LD5CED50LD5DED5LD95E45ApA20.8BpA20.9CpA21DpA21.2EpA21.446pH590.9pKaA6B5C4D3E247T1/2AB3CDE48pH7.0pH7.4ABCDE49pKa4.4pH5.4pH7.4A100B91C99D1/10E1/10050ABCpHDpHE51ABCDE652ApH5BpH4CpH9DpH7EpH8539100µg/L612.5µg/LT1/2A2hB4hC3hD5hE9h54ABCDE55ABCDE56ABCDE57pKa8.4pH7.4A90.9B99.9C9.09D99E99.9958pKa9.8pHABCDE59ABCDE60ABCDE761ABCDE62ABCDE63ABCDE64ABCDE65ABC/DEAD66ABCDE67ABCDE68ABCDE69ABCDE70ABCDE71pA28ABCDE72pHABCDEpKa50%pH73ABCDpHpKaE74ABCDE75ABCDE76ABCDE77ABCDE78pH5.090.9%pKaA2B3C4D5E679ABCDpHE809ABCDE81ABCDE82ABCDE83ApHBpHCpHDpHEpH84ABCDE85AaBbCcDc1EP45086ABCssCCmaxDCminELD87AABBCCDDEE8830%ABCDE89ABP45010CDE90A1-2t1/2B2-3t1/2C3-4t1/2D4-5t1/2E2-4t1/291ABCDE123456789108078mg9.75mg1112T1/213T1/2,T1/214151116()171819T1/2Css1LD502LD5ED95LD1ED993KDKD456(pKa=8)7pH8()pKa9.65pH91011Ke12131415161718KD5019(AUC)201?23ABC12ED5021050mg/kgABC4ABCa)ABCb)ABC5ABCED50a)ED50ABCb)AB≤C6EC5010-4mol/LKDpD27ABCKD10010-110-2mol/LEC508ABCpD2123EC50910-9.2mol/LpA2?10?11EC50LD5012pKa3.413pKa3.53.014pKa9.4pKa7.915pH1636h0.25mg1750kg300mg0.01mg/ml180816012345673h4µg/ml5h2µg/ml195hF0.2Vd=0.5L/kg310mg/kg13AssCss?20T1/2=3hF=0.5Vd=0.5L/kg210mg/kgAssCss21ABC100101EC50123456789101112(EC50)131415(ED50)16(LD50)1718KD19pD22021222324252627pA2282930pKa313233343536373839404142434445(AUC)464748495051525314A1A2A3E4E5B6C7C8E9D10B11D12D13D14A15C16B17B18D19E20C21B22B23D24E25B26C27C28B29D30B31C32E33B34A35B36D37E38C39A40A41E42D43A44B45E46A47A48C49B50D51A52B53C54E55B56D57A58A59A60B61C62B63E64A65C66B67C68E69D70B71B72B73E74D75D76A77B78E79E80B81A82C83C84A85E86B87B88C89A90D91B12345678P450NADPH9105311125135141516171819121534567891011121314151617181920