第七十二章精神科药物的临床应用

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1.ChlorpromazineThioridazinePerphenazineFluphenazine)Trifluperazine)2.ClopenthixolFlupenthixolChlorprothixeneThiothixene3.HaloperidolPimozidePenfluridol4.ClozepineClothiapineLoxapine5.Sulpiride(Tiapride)6.RisperidoneOlanzapineZotepin)7.Fluphenazinedecanoate)(Pipotiazinepalmitate)(Haloperidoldecanoate)1.2.100mg100mg1.2.3.4.5.6.7.8.1.2.3.4.5.6.7.8.1.2.3.4.1.2.13123.574.5.1/42/321.2.133.4.Neostigmine)0.51mg,5.6.7.8.9.1.2.3.39601201.12340.1g13,5(Artane)24mg13(Hyoscine)0.2mg,130.3mg(Promethazine)2550mg132550mg122550mg230.25mg13;(Valium)2.55mg232.,,3.4.Batiol50150mg3200300mg3B4,20mg,3Sargramostim510g/kg465.120/1020mg3Methylphenidate1020mg,Metaraminol1020mgSTTQT6.4mg231.1:50005102.2030mg2050mg200500ml3.4.20%250500ml65.C2g100mg6.10mg7.Megimide50mg20mg0.25g,0.375g128.tricyclicantidepressants5924174013U1.,2.3.10144.11mg/dmg/d501507525075150753005015075250201004020015401560501507525012323465.366.12,3452.5g0.25g1020mgmonoamineoxidaseinhibitorsMAOIphenelzinetranylcypromineMAO51.2.315mg75mg1530mg420mg50mg1020mg23.moclobemideMAOIMAOIMAOIMAOAMAOBMAOANA5HTMAO100mg600mg/TCAMAOI24MAOMAOITCASSRIs20g5SelectiveSerotominReuptakeInhibitorsSSRIsSSRIsFluoxetine(Prozac)Paroxetine(Seroxat)Fluvoxamine(Luvox)Sertraline(Zoloft)CitalopramCipramilSSRIs5SSRIsSSRIsSSRIsSSRIs38SSRIs1.2.CYP3.4.5.6.1.SSRIs12342SSRIsSSRIs5HTSSRIs11SSRIs(mg/d)(mg/d)(mg/d)Cita15qd1545120Flu20qd20406080Paro2030qd2030Fluvo50qdbid100200300Sert50qd501002003SSRIsSSRIs5HTSSRIs34.1SSRIsMAOIs2SSRIs4MAOIs2SSRIs3SSRIs24TCA12SSRIs4SSRIs56SSRIs6070%SSRIsSSRIsTCA75HT5SSRIsSSRIs5HTSSRIs12SSRIs20mg/d40mg/d50mg/d346080%5HT5TCAsSSRIsSTEPSSTEPSSSRIsTCASSRIs5HTSSRIsTCA80%67%65%79%57%43%46%SSRIsSSRIsREMSSRIs41103714SSRIs55HTSSRIs20%SSRIs2448721.2.3.4.SSRIsMAOISSRIs1.2.3.4.1/31/25.SSRIsMAOIMAOISSRIs1.2.3.4.MAOI5.SSRIsSSRISSSRIs1.maprotiline7075mg100200mg20212.mianserin,5123.sulpiride,1968400600mg/dTST200600/104.dibenzepin,480mg/d150mg/d5.chloprothixene,taractan6075200mg/d126.flupenthixol14.5mg675225mg/d237.LLtryptophan5HTLL68g8.TCA69.venlafaxineNA5HTDAMAO12H110.bupropion5HTNA11.trazodonePSQIYNHI2575mg12.nefazodone5HT5HT280%433%3004%5HT25HT2SSRI12(44.5)68579080%2281.2.3.4.5.6.1.2.3.1.,2.0.1/0.25/0.3/0.2Tid0.25Bid0.3Bid0.3Tid0.25Tid0.3Tid0.4Tid0.25Bid+0.5QN0.60.30.30.250.50.51.2/3.1214(668)()4.120.81.2mmol/L0.40.8mmol/L1.5mmol/L2.0mmol/L1.2.3.4.T5.6.7.8.9.1.0mmol/L1.()4001200mg/d200600mg/d2.8001800mg/d3.416mg/d()(Anxialytics)(Sedatives)(Hypnatics)1.2.()3.4.(TCA)1957()20001.2.(REM)3.4.5.5NN()21.1190%61620%2.3.4.5.6.7.1.1N26~53530mg/510mg1020mg()2.430120mg/50200mg3.()1530mg/134.20605~82.5~412mg1312mg24mg/5.23510mg/30601530mg/6.512mg4630600.75mg1mg4~8mg20mg12mg7.0.250.5mg18.781530mg9.TCA0.40.8mg134mg()19511~2104001200mg/()2550mg36(TCA)()30810200400mg13

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