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:2004205210;:2004206210:510080,,:;;;:R734.2:A:100028578(2004)08205142040,,,,,,,PCRmRNANorth2ernblottingwesternblotting,,,,,,,,,,,1,,,80%;,20%,,,,,Cojocara[1]12,65RNA,,,,,Wang[2]CDNACDNA,17,4,[3,4][5]Goodwin[6],[7,8],,,,,Bangur[9]CDNACDNA32,209,,,,9,,Beer,,[10],,2,TNM,,,,,4152004318Arindam[8]127212061712,,,,TGF2,tetranectin,ficplin3,,,PCNAMCM2MCM62p18,,p63,,,4C1;C2,11;C312S2,1BCD;C4b5,H,1,C2,C4Garber,,3[7],,,3,,,10,,DNA,,,,Powell[10]6,,GPC3,,Northernblot,GPC3,GPC3,GPC3,Ahrendt[12]p53105p53,:p53,p53,,98%,100%2%,Zhao[12]CDNA,DCCKU70,Cr[14][15],4,,,,,NorthernblotingRt2PCR,,Shih[16]CRMP21,,CRMP21,Gernma[17],22(MMP22),21(PAI21),515200431821(IL21),CEAFASCyclinECyclinB1Ki267PCNACD44,Kozaki[18],,5,Komatani[19]NB2506J2107088,NB2506J2107088,34020,ATPBCRP[/MXR/ABCP(BCRP)],BCRPPC13,2217NB2506J2107088,,BCRPTZT21027,,,,Natsume[20]TZT21027,TZT21027TZT21027,,,,Dan[21]A549G2,B1Kiguchi[22],,6,,,p53,,p53Kannan[23],p5332,p53,p53,,,,p53,p53,p53,S100A2[24],[25]7,,,,By[26]193,,,E2,[27],[28],8,,,,,,,,,,,,,,6152004318,,,,,!:[1]CojocaruG,FriedmanN,KrupskyM,etal.Transcriptionalpro2filingofnon2smallcelllungcancerusingoligonucleotidemicroar2rays[J].Chest,2002,121(3Suppl):44S.[2]WangT,HopkinsD,SchmidtC,etal.Identificationofgenesdifferentiallyover2expressedinlungsquamouscellcarcinomausingcombinationofcDNAsubtractionandmicroarrayanalysis[J].Oncogene,2000,19(12):151921528.[3],,,.[J].,1999,26(5):4462450.[4],,,.cDNA[J].,1999,18(5):4892491.[5],,,.[J].,2001,28(3):1722175.[6]GoodwinLO,MasonJM,HajduSI.Geneexpressionpatternsofpairedbronchioloalveolarcarcinomaandbenignlungtissue[J].AnnClinLabSci,2001,31(4):3692375.[7]GarberME,OlgaG.T,KarstenS,etal.Diversityofgeneexpres2sioninadenocarcinomaofthelung[J].ProcNati.Acad.Sci.USA,2001,98(24):13784213789.[8]ArindamB,WilliamG.R,JaneS.Classificationofhumanlungcar2cinomasbymRNAexpressionprofilingrevealsdistinctadenocarci2nomasubclasses[J].ProcNatl.Acad.Sci.USA,2001,98(24):13790213795.[9]BangurCS,SwitzerA,FanL,etal.Identificationofgenesover2expressedinsmallcelllungcarcinomausingsuppressionsubtrac2tivehybridizationandcDNAmicroarrayexpressionanalysis[J].Oncogene,2002,21(23):381423825.[10]BeerDG,KardiaSL,HuangCC,etal.Gene2expressionprofilespredictsurvivalofpatientswithlungadenocarcinoma[J].NatMed,2002,8:8162824.[11]PowellCA,XuG,FilmusJ,etal.Oligonucleotidemicroarrayanal2ysisoflungadenocarcinomainsmokersandnonsmokersidentifiesGPC3asapotentiallungtumorsuppressor[J].Chest,2002,121(3Suppl):6S27S.[12]AhrendtSA,ChowJT,YangSC,etal.Alcoholconsumptionandcigarettesmokingincreasethefrequencyofp53mutationsinnon2smallcelllungcancer[J].CancerRes,2000,60(12):315523159.[13]ZhaoYL,PiaoCQ,WuLJ,etal.Differentiallyexpressedgenesinasbestos2inducedtumorigenichumanbronchialepithelialcells:implicationformechanism[J].Carcinogenesis,2000,21(11):200522010.[14]YeJ,ShiX.Geneexpressionprofileinresponsetochromium2in2ducedcellstressinA549cells[J].MolCellBiochem,2001,222(122):1892197.[15]OkabeS,FujimotoN,SueokaN,etal.Modulationofgeneex2pressionby(2)2epigallocatechingallateinPC29cellsusingacDNAexpressionarray[J].BiolPharmBull,2001,24(8):8832886.[16]ShihJY,YangSC,HongTM,etal.Collapsinresponsemediatorprotein21andtheinvasionandmetastasisofcancercells[J].JNatlCancerInst,2001,93(18):139221400.[17]GemmaA,TakenakaK,HosoyaY,etal.Alteredexpressionofseveralgenesinhighlymetastaticsubpopulationsofahumanpul2monaryadenocarcinomacellline[J].EurJCancer,2001,37(12):155421561.[18]KozakiK,KoshikawaK,TatematsuY,etal.Multi2facetedanalysesofahighlymetastatichumanlungcancercelllineNCI2H4602LNM35suggestmimicryofinflammatorycellsinmetastasis[J].Oncogene,2001,20(31):422824234.[19]KomataniH,KotaniH,HaraY,etal.Identificationofbreastcancerresistantprotein/mitoxantroneresistance/placenta2specif2ic,ATP2bindingcassettetransporterasatransporterofNB2506andJ2107088,topoisomeraseIinhibitorswithanindolocarbazolestructure[J].CancerRes,2001,61(7):282722832[20]NatsumeT,NakamuraT,KohY,etal.Geneexpressionprofil2ingofexposuretoTZT21027,anovelmicrotubule2interferinga2gent,innon2smallcelllungcancerPC214cellsandastrocytes[J].InvestNewDrugs,2001,19(4):2932302.[21]DanS,YamoriT.RepressionofcyclinB1expressionaftertreat2mentwithadriamycin,butnotcisplatininhumanlungcancerA549cells[J].BiochemBiophysResCommun,2001,280(3):8612867.[22]KiguchiT,NiiyaK,ShibakuraM,etal.Inductionofurokinase2typeplasminogenactivatorbytheanthracyclineantibioticinhu2manRC2K8lymphomaandH69lung2carcinomacells[J].IntJCancer,2001,93(6):7922797.[23]KannanK,AmariglioN,RechaviG,etal.DNAmicroarraysi2dentificationofprimaryandsecondarytargetgenesregulatedbyp53[J].Oncogene,2001,20(18):222522234.[24]FengG,XuX,YoussefEM,etal.DiminishedexpressionofS100A2,aputativetumorsuppressor,atearlystageofhumanlungcarcinogenesis[J].CancerRes,2001,61(21):799928004.[25]SakaueM,AdachiH,DawsonM,etal.InductionofEgr21ex2pressionbytheretinoidAHPNinhumanlungcarcinomacellsisdependentonactivatedERK1/2[J].CellDeathDiffer,2001,8(4):4112424.[26]ByR.M.Bremnes,R.Veve,E.Gabrielson,etal.High2Through2putTissueMicroarrayAnalysisUsedtoEvaluateBiologyandPrognosticSignific