第八节抗血栓药

12ƒ–––ƒ–3ƒƒƒ4ƒƒƒ––5ƒ–ƒƒ6ƒClopidogrelSNClHOO7ƒS--(2-)-6,7-[3,2-c]-5(4H)-ƒS)--(2-Chlorophenyl)-6,7-dihydro-thieno[3,2-c]pyridine-5(4H)-aceticacidmethylesterSNClHOOSN765431cba8ƒƒ–ƒ–NC()C()H,–SSNClHOO9SNH2(1)HCHO(2)HClSNHClOClOResolution±-Clopidogrel+-ClopidogrelSNHOOClSNHOOCl10ƒƒP450ƒ—SR26334––SR26334SNHHOOCl11ƒADP–ƒADPGPIIb/IIIaƒ12ƒ–––ƒ1314ƒƒHOOOO15AspirinAspirinƒƒƒ1954ƒ1971PGƒ16ƒƒ–17ƒAspirin–––1819ƒWarfarinSodiumƒƒOONaOO20ƒ4--3-(3--1-)-2H-1--2-ƒSodium4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-oneOONaOO21(C2H5)3NOOOOHOOHOOHClNa2CO3H2SO4Ac2OOOONaOOOOOHOO2211ƒVitK–IIVIIIXX–g-Ca2+–Ca2+OO2322ƒVitK–WarfarinK–OOOONaOO24ƒƒSƒROOHOOOOHOOHS-OOHOOOOHOOHOR-25ƒƒƒ()WarfarinOONaOO26DicumarolOOHOOOHOAcenocoumarolOOHOONO22728SNClHOOƒ––ƒOONaOO29ƒ