胃肠动力中药作用机制研究

1,1,1,2(1.,210029;2.,210029)[],,,,,:,;,,,[];;;;[]R285[]A[]1672-1977(2004)03-0163-04StudyonthemechanismoftraditionalChinesemedicinesinpromotinggastrointestinalperistalsisWEIMu-Xin1,WEILan-Fu1,ZHOUBai-Cang1,ZHAOGuo-Ping2(1.DepartmentofTraditionalChineseMedicine,FirstAffiliatedHospital,NanjingMedicalUniversity,Nanjing,JiangsuProvince210029,China;2.InstituteofLiterature,NanjingUniversityofTraditionalChineseMedicine,Nanjing,JiangsuProvince210029,China)ABSTRACTTraditionalChinesemedicinehasaccumlatedrichexperienceintreatingdysfunctionofgastrointestinalperistalsis.Inre-centyears,alargenumberofstudieshavebeenmadeonthemechanismandeffectsoftraditionalChinesemedicinesonthegastrointes-tinalperistalsis,andtheconceptofgastrointestinalpromotingChinesemedicinehasbeenadvocated.ThesetraditionalChinesemed-icinescanbedividedintothreetypes:promotingthegastrointestinalperistalsis,inhibitingthegastrointestinalperistalsis,andbi-direc-tionalmodulating.Theinvivoand/orinvitroexperimentsshowedthatsomeofthetraditionalChinesemedicinesforactivatingbloodorregulatingqicouldpromotethestomachperistalsis,andthetraditionalChinesemedicinesformoisteningintestinestorelieveconstipa-tionorinvigoratingspleentopromotedigestioncouldacceleratetheintestinalperistalsis.Themechanismliesintheneuroregulationandgut-peptideregulation.Furtherresearchonmulti-regulationandofmulti-targetshouldbedone,forthemechanismofthetraditionalChinesemedicinesinregulatingthegastrointestinalperistalsisisfarmorecomplicated.KEYWORDSgutdiseasemedicine,gutactivity;neuralregulation;gutpeptideregulation;traditionalChinesemedicinesJChinIntegrMed,2004,2(3):163-166,171,,,,,,[1],,:;1,[1],1.1,,3612004523JChinIntegrMed,May2004,Vol.2,No.3[]135333(No.135038)[](1959-),,,.Correspondenceto:WEIMu-Xin,MD,Professor.E-mail:[e-mail],[2],25%Wistar[3,4],[5],[6],,[7](10g/kg),,,,[8],,,[9],,,,1.2,,[10]7,,7,;,,,,[11]6,,,,,,,,[12]1.3,,[13],(),SD,,SD,SD,,2,,,,[14](),,[15]6(),,5[16]:,;,,,,3,,,10,[17],,,3,,,,,,,4612004523JChinIntegrMed,May2004,Vol.2,No.3[18],,,,,11,[19],,,4,,4.1,,,M[20][21],,M[22],,M,[23],M,,M[22][24],,,,[25],,;,,,4.2[26],[27],5,[28],,,5,,,,P5.1,,,,[29]:,,-2,,30min,EC2,[30][31]62,[32],[33],,[34]:,[35,36],;,,,:5612004523JChinIntegrMed,May2004,Vol.2,No.35.2PP,[37],Hartley,P,[38],1h6h,,P[39],,,,[40]5.3[41],,6,,,,,,,;,,,,,,,,,,,,,[]1.[J].,1997,(4):18-19.2,.[J].,2000,12(2):157-158.3,,.[J].,2003,19(3):58-59.4,,.[J].,2003,37(3):46-48.5,,.[J].,2003,19(2):66-67.6,,.[J].,2003,11(1):6-8.7,,,.[J].,1984,25(12):63-64.8,,,.[J].,2001,12(3):221-223.9,,,.[J].,2001,2l(7):498-500.10,,,.[J].,1998,24(3):3-5.11,,,.[J].,1998,24(4):6-8.12,,,.[J].,2002,21(3):174-176.13,,,.[J].,1999,22(1):39-41.14,,,.4LD50[J].,1994,19(8):454-455.15,,,.[J].,1992,15(4):36-38.16.[J].,1976,(12):39-43.17,,,.[J].,2001,24(6):19-21.18,,.[J].,1999,15(2):41-42.19,,,.[J].,2001,8(6):362-363.20,,,.M[J].,2002,22(1):22-24.21,.[J].,1993,15(6):9-11.22,.[J].,1998,6(2):107-108.23,,,.[J].,1996,16(5):261-264.24,,.[J].,2000,8(4):236-238.25,,,.[J].(),2001,37(5):95-97.(171)6612004523JChinIntegrMed,May2004,Vol.2,No.3[]1GanzT.Defensins:antimicrobialpeptidesofinnateimmunity[J].NatRevImmunol,2003,3(9):710-720.2GoldmanMJ,AndersonGM,StolzenbergED,etal.Humanbeta-defensin-1isasalt-sensitiveantibioticinlungthatisinactivatedincysticfibrosis[J].Cell,1997,88(4):553-560.3TomitaT,NagaseT,OhgaE,etal.Molecularmechanismsunderly-inghumanbeta-defensin-2geneexpressioninahumanairwaycellline(LC2/ad)[J].Respirology,2002,7(4):305-310.4HarderJ,BartelsJ,ChristophersE,etal.Apeptideantibioticfromhumanskin[J].Nature,1997,387(6636):861.5HuangGT,ZhangHB,KimD,etal.Amodelforantimicrobialgenetherapy:demonstrationofhumanbeta-defensin2antimicrobialactivitiesinvivo[J].HumGeneTher,2002,13(17):2017-2025.6,,,.--2[J].,2003,20(3):451-454.7MangtaniP,CuttsF,HallAJ.Efficacyofpolysaccharidepneumo-coccalvaccineinadultsinmoredevelopedcountries:thestateoftheevidence[J].LancetInfectDis,2003,3(2):71-78.8SrivastavaIK,LiuMA.Genevaccines[J].AnnInternMed,2003,138(7):550-559.9BeacheyEH.Bacterialadherence:adhesin-receptorinteractionsme-diatingtheattachmentofbacteriatomucosalsurface[J].JInfectDis,1981,143(3):325-345.10ThomasRJ,BrooksTJ.OligosaccharidereceptormimicsinhibitLe-gionellapneumophilaattachmenttohumanrespiratoryepithelialcells[J].MicrobPathog,2004,36(2):83-92.11,,,.-MSHA[J].,2002,14(3):173,175.12BoneRC,BalkRA,CerraFB,etal.Definitionsforsepsisandor-ganfailureandguidelinesfortheuseofinnovativetherapiesinsepsis[J].Chest,1992,101(6):1644-1655.13BoneRC.Towardatheoryregardingthepathogenesisofthesystemicinflammatoryresponsesyndrome:whatwedoanddonotknowaboutcytokineregulation[J].CritCareMed,1996,24(1):163-172.14,.[J].,2002,19(4):340-343.15,.[J].,1991,26(1):39-40.16MurataA,KikuchiM,MishimaS,etal.Cytokineimbalanceincriticallyillpatients:SIRSandCARS[J].NipponGekaGakkaiZasshi,1999,100(7):414-418.17.[J].,2003,1(2):86-88,15718,.[J].,2002,12(2):185-187.[]2004-03-15[](166)26,,.[A].[C].1997.137.27,,,..[J].,1997,13(1):4-6.28,.[J].,2000,8(4):377-381.29,,.E2[J].,1994,10(6):7-8.30,,.[J].,1994,14(7):406-408.31,,