药品及个人护理用品_PPCPs_的污染来源_环境残留及生态毒性

(PPCPs)31,21,333(1,110016;2,100039;3,300071),(PPCPs),2090,PPCPs,,,,PPCPs;PPCPs;PPCPs,(PPCPs);;;S963A1000-4890(2009)09-1878-13Pollutionsources,environmentalresidues,andecologicaltoxicityofpharmaceuticalsandpersonalcareproducts(PPCPs):Areview.ANJing1,2,ZHOUQi2xing1,3(1KeyLaboratoryofTerrestrialEcologicalProcess,InstituteofAppliedEcology,ChineseAcademyofSciences,Shen2yang110016,China;2GraduateUniversityofChineseAcademyofSciences,Beijing100039,Chi2na;3KeyLaboratoryofPollutionProcssesandEnrironmentalCriteria(MinistryofEoluation),CollegeofEnvironmentalScienceandEngineering,NankaiUniversity,Tianjin300071,China).ChineseJournalofEcology,2009,28(9):1878-1890.Abstract:Withthelargescaledevelopmentofpharmaceuticalandcosmeticindustries,thepro2ductionanduseamountofpharmaceuticalsandpersonalcareproducts(PPCPs)areremarkablyincreased,resultinginthePPCPsremaininginwater,soil,andairenvironment.Regrettably,asalargeclassofenvironmentalpollutants,PPCPshavenotdrawnadequateattentiontillthelate1990s.Duetothecontinuousinputtotheenvironmentinhighquantity,theresidualconcentra2tionofPPCPsisincreasing,andgraduallyshowsecologicaltoxicitytothemicroorganisms,plantsandanimals,andeven,potentialecologicalrisktohumanbeings.Basedonthesum2upofpub2lishedliteratures,thispaperanalyzedthepollutionsourcesandenvironmentalremainingofPPCPs,aswellastheecologicaltoxicityofresidualPPCPstothemicroorganisms,plants,ani2mals,andhumanbeings.ThemainscientificissuesrelatedtoPPCPs,whichshouldbere2searchedinthefuture,weresuggested.Keywords:pharmaceuticalsandpersonalcareproducts(PPCPs);pollutionsource;residualconcentration;ecologicaltoxicity.3(2004CB418503)(20777040)33E2mail:[e-mail]:2009201204:200920520330,,,,ChineseJournalofEcology2009,28(9):1878-1890,,1999(EPA),Daugh2tonTernes(1999),PPCPsEPAPPCPs,(pharmaceuticalsandpersonalcareproducts),PPCPs(),PPCPs(Smitaletal.,2004;,2006;Jjemba,2006),,PPCPs,PPCPs,PPCPs,,1PPCPs111PPCPs,,PPCPs,,,,,,,,()(Montforts,1999),(Addison,1984)Kroker(1983)90%(P450),()PPCPs,(Boschetal.,1998),;()112PPCPs(Rogers,1996),/,():1),,;2),PPCPs,(Velag2aleti,1997),,PPCPs,(),PPCPsYu(2006)18PPCPs24h,,10PPCPs,PPCPs,PPCPs,9781:(PPCPs),,PPCPs(Ternes,1998),PPCPs,PPCPsPPCPs,Vieno(2007)1228PPCPs,,PPCPs1001060ngL-1,24755ngL-1,,PPCPs,PPCPs,PPCPs,,PPCPs,PPCPs,PPCPs,,PPCPs,Ternes(1998)(),60%5%,()PPCPsSTWs,PPCPs3:1);2)();3),()(Ternes,1998),PPCPs,,,,,,PPCPs(Milstein,1999)113(),,()()PPCPs(),PPCPs,PPCPsPPCPs,(,),,,,(Velagaleti,1997)PPCPsPPCPsChristensen(1995)PPCPs,()45,Christensen(1995),PPCPs5%,,114PPCPsPPCPs,,,,LeMunekage(2004)4,4,4261312615196mgL-1;(42)()()PPCPs;,0881289,(,2007),()PPCPs()PPCPs,,115,()(),,(),,,PPCPs;(),,,2225222DNA(Stevenson&Davies,1999)2PPCPs211PPCPs21111PPCPs2090,PPCPs(Sedlaketal.,2000;Kolpinetal.,2002;Weigeletal.,2004),19992002,30139PPCPs,89%,60%(Kolpinetal.,2002)Boyd(2003)A,221012416ngL-1;PPCPs,Mold2ovan(2006)(30010000ngL-1),p2(100300ngL-1)Roberts(2006)7,42370ngL-1,Ternes(1998)Hirsch(1999)PPCPs,PPCPs21112PPCPsPPCPs,,106L240kg(Kinneyetal.,2006)(Mantovietal.,2005)16000t2000hm2(Toppetal.,2008)PPCPs,Kupper(2004)165,HHCB2013mgkg-1,AHTN713mgkg-1,011118mgkg-1,Bester(2003)Hei2dlerHalden(2007)55mgkg-1PPCPs(Heberer,2002;Stevensetal.,2003;Horiietal.,2007),,,1881:(PPCPs)1Tab.1ResidualconcentrationofantibioticsinsoilsamplesPPCPs(ngkg-1)305000Boxalletal.,20051000850039000Hamscheretal.,200511000HÊperetal.,2002600052000Schller,1998200000900000Winckler&Grafe,2000;Hamscheretal.,2002,,(1)212PPCPsPPCPs,Kim(2007)PPCPs,,80%,Xu(2007)2H2O4,3131213ngL-1,8,,,877460ngL-1Zeng(2005)6,80%,01715211214mgkg-1,,7031681mgkg-1PPCPs,PPCPsPPCPs2003,218t,1t,60%65%(Richardsonetal.,2005)2004,501185t,25%200519,430132tPPCPs,,70%,,30%,2003,,,,PPCPs213PPCPs21311,,()AlexanderFleming1982,UCS(2001),200016200t;199913288t2003,218t1t(Richardsonetal.,2005),(Heberer&Stan,1997;Drewesetal.,2002;Seinoetal.,2004),Batt(2006),(Tri2methoprim)(Clindamycin),01090610gL-180,(Macrolide)(Sulfonamide)(Tetracycline)(Hirschetal.,1999;Ternesetal.,2004)WincklerGrafe(2000),(TCs)450900gkg-1Hamscher(2002)410mgkg-1,011mgkg-1;(010cm)8612gkg-1,,,2030cm,17117gkg-1288128921312,,,,,(),,Kim(2007)7,(81925ngL-1)172(113ngL-1)(21236ngL-1)172(111ngL-1)(Boydetal.,2003)21313,,,,,()():()()(),19877000t,61%,35%;1996,5600t,70%,12%(Sommer,2004),,2080,Yamagishi(1981),1994Fromme(2001),Ricking(2003),,1300520ngL-1Kup2per(2006)(HHCB)(AHTN)44201430ngL-1KallenbornGatermann(2004),HHCB110676pgm-3,AHTN301776pgm-3,,,,Kupper(2004),2013713mgkg-1(),(AHDI)(ATII)011118mgkg-1()Zeng(2005)6,(DPMI)5141621121401715611950159921870mgkg-1();,HHCB703168mgkg-1()Fromme(2001),,1159gL-10192mgkg-11513mgkg-1();,21314,,(),(),,(2)21315,,,,(Sandersonetal.,2006),199712349t,21450t,28892t(Klaus,2001),,3881:(PPCPs)2Tab.2Residualconcentrationofanti2inflammatoryanal2gesicinsoilsamples(gL-1)610Ternes,1998115Richardson&Bowron,19850134613Ternes,19981112015118Buseretal.,19980100101310314Ternes,19980153313Buseretal.,199801008016Ternes,19980120195Stumpfetal.,19990152Ternes,19980139016Stumpfetal.,19993004000Christensenetal.,1995,2070,,350t(Heinzetal.