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2005,14(6):947-952@jeesci.comJST205100761963200SCI50E-mail:hyhu@tsinghua.edu.cn*E-mail:hyhu@tsinghua.edu.cn2005-05-29*//100084305PPCPsng/L~µg/LPPCPsPPCPsPPCPsPPCPsPPCPsPPCPsPPCPsX787A1672-2175200506-0947-0630PPCPs51999ChristianG.DaughtonThomasA.TernesPPCPsPharmaceuticalsandPersonalCareProductsintheEnvironment:AgentsofSubtleChange?2000[1]PPCPspharmaceuticalsandpersonalcareproducts1999EnvironmentalHealthPer-spectivesChristianG.Daughton[1]PPCPsPPCPs[1,2]PPCPsPPCPs[3]PPCPsPPCPs[4]PPCPs50PPCPs[5]PPCPs1198719967000t/a8000t/aGalaxolideTonalide20001800t20t948146200511Yamagishi20XX200g/80%AOXSteger-Hartmann[7]X[8][9]KÜmmerer[10](CBT)(OECD301D)SOSCBTWarmanThomas[11]vanGoll[11]2×106hm2130mg10cm0.87mg/kg1~5mg/kgBatchelder[11]160mg/L60~90LanzkyHalling-Sørensen[11]()EC102.03mg/LEC5012.5mg/LBaguer[11][12]1PPCPsTable1CommonPPCPsintheenvironmentCASGalaxolide1222–05–5C18H26OTonalide21145–77–7C18H26OIopromide73334-07-3C18H24I3N3O8XRoxithromycin80214-83-1C41H76N2O15Ciprofloxacin85721-33-1C17H18FN3O3Norfloxacin70458-96-7C16H18O3N3FEstrone53-16-7C18H22O217β-17β-estradiol50-28-2C18H24O2·0.5H2O17α-17α-ethinylestradiol57-63-6C20H24O2Ibuprofen15687-27-1C13H18O2Naproxen22204-53-1C14H14O3Diclofenac15307-86-5C14H13O2NTriclosan3380-34-5C12H7Cl3O2PPCPs949DESHexestrolEthinylEstradiolQuinestrol[13]7ng/L[13][13]Heberer2.51µg/L17%Ternes69%[14]MartaCarballa[2]2.64~5.701.79~4.60µg/L0.91~2.100.80~2.60µg/LStumpf[15]0.30.6µg/L1~3.3µg/L[16]0.22µg/L0.04µg/L13µg/L[14]90%Kolpin17%10µg/L[14]QAC199712349t21450t28892tStatistischesBundesamt,20000.05~0.1mg/L[17]AnaAgüera[18]1.3~30.1µg/L0.4~22.1µg/LAnaAgüera0.27~130.7µg/kgPPCPs2PPCPs2199920005µg/L2PPCPs[19]Table2ReportedPPCPsofsurfacewaterintheliterature[19]/(µg⋅L-1)0.294~0.40520000.045~0.12020000.02~0.0520000.01200017β-0.02~0.0520000.10199619980.05199619980.31999200110199920010.03~0.220010.01219980.00519990.51999200110199920010.6199920005199920000.08720000.1~1.019980.015~0.05619970.01620011.920000.03~0.220010.01320010.04920010.00520000.00519990.8820009501462005110.087µg/LTernes20010.049µg/LM.Farré20010.03~0.2µg/LH.R.Buser19981.0µg/L0.1µg/L100.005µg/L[20]PPCPsPPCPsPPCPs3PPCPsPPCPs[21]Eckel[22]19681969EckelPPCPsPPCPsPPCPsPPCPsHeberer[23]20021280PPCPs4PPCPsPPCPsPPCPsPPCPsPPCPs(DWCCL)PPCPsPPCPs(DWCCL)[26]PPCPsPPCPsPPCPsPPCPsKangXia[16]PPCPsPPCPs-Kd-PPCPsThomasA.Ternes[27]PPCPsKdPPCPsPPCPs5PPCPsPPCPsPPCPsPPCPsDifrancesco[32]()()Golet[28]4PPCPs[19,24,25]Table4ReportedPepsofdrinkingwaterintheliterature[19,24,25]/(µg⋅L-1)0.4~0.920010.16519940.27019983PPCPs[19]Table3ReportedPPCPsofgroundwaterintheliterature[19]/(µg⋅L-1)0.4~0.920010.4~0.920015PPCPs[28−32]Table5ReportedPepsofsludgesintheliterature[28−32]/(mg·kg-1)1)1.54~2.3720021.79~2.4920021.86~2.4420020.0015~0.0071200212.620010.5~12.620011PPCPs951FQsFQsFQs6PPCPsPPCPsPPCPs[3]PPCPsPPCPsPPCPsPPCPs12000PPCPs1~2%[33]PPCPsPPCPs[1]EPA.Pharmaceuticals&PersonalCareProductsintheEnvironment:AnEmergingConcern?.[2]MARTAC,FRANCISCOO,JUANML,etal.Behaviorofpharma-ceuticals,cosmeticsandhormonesinasewagetreatmentplant[J].WaterResearch,2004,38:29182926.[3]SNYDERSA,WESTERHOFFP,YOONY,etal.Pharmaceuticals,personalcareproducts,andendocrinedisruptorsinwater:Implica-tionsforthewaterindustry.Environment[J].EngineeringScience,2003,20(5):449469.[4]TERNESTA,MEISENHEIMERM,MCDOWELLD.Removalofpharmaceuticalsduringdrinkingwatertreatment[J].EnvironmentalScience&Technology,2002,36:38553863.[5]GLENRB,JORDANMP,ZHANGSHY,etal.Pharmaceuticalsandpersonalcareproducts(PPCPs)andendocrinedisruptingchemicals(EDCs)instormwatercanalsandBayouSt.JohninNewOrleans,Louisiana,USA[J].TheScienceoftheTotalEnvironment,2004,333:137148.[6]TILLL,DAVIDE.Nitromuskandpolycyclicmuskcompoundsaslong-terminhibitorsofcellularxenobioticdefensesystemsmediatedbymultidrugtransporters[J].EnvironmentalHealthPerspectives,2005,13(1):1724.[7]STEGER-HARTMANNT,LÄNGER,SCHWEINFURTHH.Environ-mentalriskassessmentforthewidelyusediodinatedX-raycontrastagentiopromide(ultravist)[J].EcotoxicologyAndEnvironmentalSafety,1999,42:274281.[8]SIMONDC,JOHNM,JOHNB.Ecosystemresponsetoantibioticsenteringtheaquaticenvironment[J].MarinePollutionBulletin,2005,51:218223.[9],,.[J].,2004,24(5):515517.YUDJ,ZENGZHL,CHENZHL.Progressofstudiesonwatereco-environmenteffectsofresidualtetracycline[J].ChineseJournalofVoterinaryScience,2004,24(5):515517.[10]KÜMMERERK,AL-AHMADA,MERSCH-SUNDERMANNV.Biodegradabilityofsomeantibiotics,eliminationofthegenotoxicityandaffectionofwastewaterbacteriainasimpletest[J].Chemosphere,2000,40:701710.[11]ANGELJB,JOHNJ,PAULHK.Effectsoftheantibioticsoxytetra-cyclineandtylosinonsoilfauna[J].Chemosphere,2000,40:751757.[12],,,.[J].,2001,20(5):4450.BAOGZH,DONGDM,LIXL,etal.Progressofstudiesoneco-logicaleffectsofecoestrogen[J].ChineseJournalofEcology,2001,20(5):4450.[13],,.[J].,2003,22(1):5763.LIUXL,LIUB,DENGNSH.Studyprogressofenvironmentalen-docrinedisruptors[J].ShanghaiEnvironmentalSciences,2003,22(1):5763.[14]THOMASH.Occurr