基于系统论的中药大品种二次开发研究思路-成旭东

··1231*1121.2100282.2100283.215123。、、。2013-06-072012ZXY2012009*[e-mail][e-mail]。。。。、、。、、。1。1-2。、、。、、。、、。2。、、、3。、。。、、、。、、4。3。2006《2006－2020》“”““””。《“”》。“·9634·3824201312Vol.38Issue24December2013”“”“”。2010、、、、。20、、。“”“”。。“”。、、、。、、、、。60%5001。1Table1ApprobationnumbersofseveralChinesemedicines/1070228693706257205539194。。。。、、、。“”。。。5。42、、。。2、、、、。、、、、。、、、、1。1Fig.1EntiretythoughtoftraditionalChinesemedicineseconda-ryexploitation4.14.1.1。。6123、、、4·0734·3824201312Vol.38Issue24December20134。。、、、、。、、2、7。。。、、、、、、、8。99、73。。4.1.2。。、、、、、10。、。。。、。4.1.3、。。11。5--2-11-13。。。、14。。、、15。、52515。《》、、、、。。、。16。4.24.2.1。、、、。、、。、、·1734·3824201312Vol.38Issue24December2013、、、、、、“”17-20。、、、、、、、、、pH21-29。HPLC-DADHPLC-MSGC-MSUPLC-MS/MSUPLC-Q-TOF-MS、、30-32。。、、FDAII33。。4.2.2、、。。、、。、。。、、、。、、、。34。、。/GLP35。4.2.3。、、、。。、36-40。《》41-42。5。2、、。、、。1.Ｒ＆DJ.200530181409.2.J.20104510721.3.HPLC-PADJ.200830121789.4.———J.2010335300.5.J.20035613.6.J.———20079116.7.J.200742295.·2734·3824201312Vol.38Issue24December20138.J.20123711.9.J.200569529.10.JNK1mＲNAJ.200927102089.11.———ⅠJ.1998234230.12.———ⅡJ.1998235291.13.———ⅢJ.1998238483.14.“”J.2012376865.15.M.1985125.16.J.20081951191.17.J.2009402316.18.CO2J.200833172104.19.J.2010414592.20.J.201237142181.21.ⅡAJ.20123791469.22PSrinarongJHFaberMＲVisseretal.Stronglyenhanceddissolutionrateoffenofibratesoliddispersiontabletsbyincorpo-rationofsuperdisintegrantsJ.EurJPharmBiopharm2009731154.23.J.200525121143.24ADukic-OttMThommesJPＲemonetal.Productionofpel-letsviaextrusion-spheronisationwithouttheincorporationofmi-crocrystallinecelluloseacriticalreviewJ.EurJPharmBiop-harm200971138.25.J.20104191449.26.ADME/ToxJ.200839111746.27.2J.200833242908.28.J.2010455353.29.HepsJ.201035202679.30.J.2000226395.31LaiYHNiYNKokotS.AuthenticationofCassiaseedsonthebasisoftwo-wavelengthHPLCfingerprintingwiththeuseofche-mometricsJ.ChinChemLett2010212213.32NiYNLaiYHBrandesSetal.Multi-wavelengthHPLCfin-gerprintsfromcomplexsubstancesanexploratorychemometricsstudyoftheCassiaseedexampleJ.AnalChimActa200964711149.33.J.200817242083.34.J.2009406841.35.J.20031311.36.J．2007182160.37.J.2004295489.38.J.200723459.39.J.2007235222.40.J.20051613.41.J.2007511.42.J.2006173233.·3734·3824201312Vol.38Issue24December2013ThinkingofstudyonsecondarydevelopmentofmajortraditionalChinesemedicinevarietiesbasedonsystemtheoryCHENGXu-dong123JIAXiao-bin1*FENGLiang1JIANGJun121.KeyLaboratoryofNewTraditionalChineseMedicineDrugDeliverySystemunderStateAdministrationofTraditionalChineseMedicineJiangsuProvincialAcademyofChineseMedicineNanjing210028China2.NanjingUniversityofChineseMedicineNanjing210028China3.SuzhouALGBioscienceCo.Ltd.Suzhou215123ChinaAbstractThesecondarydevelopmentoftraditionalChinesemedicinesTCMsisanimportantcontentofTCMmodernizationprocessaswellasanimportantpathfordevelopingnewTCMdrugs.UndertheguidanceofthesystemtheoryinresponsetothelackoftheoverallguidelineandpracticalmethodsforthesecondarydevelopmentofTCMsatpresentweintroducedtheoverallthoughtofthesecondarydevelopmentofmajorTCMvarietiesaswellastherolesandcontentsofclinicalresearchpharmacologyandpharmaceu-ticsintheprocessofthesecondarydevelopmentofmajorTCMvarietiessoastoprovidesystematicstrategiesandmethodsforthede-velopmentofmajorTCMvarieties.KeywordstraditionalChinesemedicinesecondarydevelopmentsystemtheorythoughtofstudydoi10．4268/cjcmm20132434·4734·3824201312Vol.38Issue24December2013