药用植物来源的_葡萄糖苷酶抑制剂研究进展

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©1994-2010ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.(1.,730000;2.,730000)[]2,2,2,30,2,2[]2;;;[]20090709012[](GZK2200921)[]3,,,Tel:13088775264,E2mail:lynjm2004@hotmail.com2,,,,,,,[122],2(),[324],,2,,2,21230,2125,,22122211211114222D24222D2(PNPG),PNPG2,,[89]:,23710min,PNPG3710min,Na2CO3,400nm,,,211122,PNPGPNPG,,[89]211132060,,2[90][91](THP)2,:(THP)8min,THP,,252h,NaCl2,,,PNPG,37,10min,10mL,,2,PNPG3361351220106Vol135,Issue12June,2010©1994-2010ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.[5]:2[6]:3[728]:4[9]:232O25[10]:32O22D2(1Ê22)22D2(-)232O22D26[11]:232O22L23,422E2232O22L232E,42Z227[12]:272O221628[13]:9[14]:72(3,42)2N2[42()]272(42,32)2N2[(42)]210[15]:A(-)2228211[16]:212[17]:13[18]:3,423,524,5214[19]:282O22D2282O22D215[20]:16[21]:17[22]:18[23]:272O22D219[24]:(1)(2)20[25]:325221[26]:22[27]:23[28]:24[29]:bartogenicacid25[30231]:gypsophin26[32]:27[33]:28[34]:29[35]:30[36]:31[37]:32[38239]:salacinol33[40]:VIV34[41]:(-)232O2(-)232O235[42]:TCAA36[43]:37Fagaratessmannii[44]:3222162238Garciniabrevipedicellata[45]:39[46]:dolichandrosideA40Oriciopsisglaberrima[47]:41[48]:42[49]:43[50]:1,2,3,4,622O222244[51]:piperumbellactams(123)45[52]4361351220106Vol135,Issue12June,2010©1994-2010ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.[52]47[52]48[53]49[53]50[54]51[55]52[56]53[56]54[56]55[56]56[56]57[56]58[56]59[56]60[56]61[56]62[57]63[58]64[58]65[58]66[58]67[59]68[60]69[61]70[62]71[63]72[63]73[64]74[65]275[66]276[67]77[68]78[69]279[69]280[69]281[69]282[[69]283[69]284[69]285[69]286[69]287[69]288[69]289[69]2290[69]291[69]292[70]93[70]94[70]95[70]96[71]97[72]5361351220106Vol135,Issue12June,2010©1994-2010ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.[73]99[74]100[74]101[74]102[74]103[74]104[74]105[74]106[74]107[74]108[74]109[74]110[75]111[76]112[77]113[78]114[78]115[79]116[79]117[80]118[81]:119[82]:120[83]:121[84]:122[3]:123[85]:124[86]:125[87288]:,[89]211142,[92]:96PNPG,2,,3715min,Na2CO3,,,21115Caco22Caco22,,[93]Caco2222,[57]:Caco226,100%(5d),1420d,,2mL(PBS)3,()PBS,1mLPBS37,5%CO22h,,,2,,,,2122,[94],2:6361351220106Vol135,Issue12June,2010©1994-2010ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.[13,37239,53,62263,77,85],(),2[6,38239,53,61,64,68,73,83],,,,,2,2,,3,2,2[13,24,37,39,45],,2,,Caco222,2,,,2,Caco22,,Caco22,2,,22,,2,22,2,[][1]AshokKT,RavindraMK,SachinBA,etal.Reductioninpost2prandialhyperglycemicexcursionthrough2glucosidaseinhi2bitionby2acetamidocarbonylcompounds[J].BioorgMedChemLett,2008,18:4130.[2]AliH,HoughtonPJ,SoumyanathA.2Amylaseinhibitoryac2tivityofsomemalaysianplantsusedtotreatdiabetes,withparticu2larreferencetoPhyllanthusamarus[J].JEthnopharmacol,2006,107:449.[3]ShobanaS,SreeramaYN,MalleshiNG.Compositionanden2zymeinhibitorypropertiesoffingermillet(EleusinecoracanaL.)seedcoatphenolics:Modeofinhibitionof2glucosidaseandpan2creaticamylase[J].FoodChem,2009,115:1268.[4]MuraiA,IwamuraK,TakadaM,etal.Controlofpostprandialhyperglycaemiabygalactosylmaltobionolactoneanditsnovelanti2amylaseeffectinmice[J].LifeSci,2002,71:1405.[5]Jong2AnurakkunN,BhandariMR,GaoH,etal.2GlucosidaseinhibitorfromChinesealoes[J].Fitoterapia,2008,79:456.[6]IshikawaA,YamashitaH,HiemoriM,etal.CharacterizationofinhibitorsofpostprandialhyperglycemiafromtheleavesofNeriumindicum[J].JNutrSciVitaminol,2007,53:166.[7]TabopdaTK,NgoupayoJ,LiuJW,etal.2Glucosidaseinhibi2torsellagicacidderivativeswithimmunoinhibitorypropertiesfromTerminaliasuperba[J].ChemPharmBull,2008,56(6):847.[8]WansiJD,LallemandMC,ChiozemDD,etal.2GlucosidaseinhibitoryconstituentsfromstembarkofTerminaliasuperba(Combretaceae)[J].Phytochemistry,2007,68:2096.[9]ShibanoM,KakutaniK,TaniguchiM,etal.Antioxidantconstitu2entsinthedayower(CommelinacommunisL.)andtheir2glu2cosidase2inhibitoryactivity[J].JNatMed,2008,62:349.[10]Jong2AnurakkunN,BhandariMR,KawabataJ.2Glucosidaseinhibitorsfromdeviltree(Alstoniascholaris)[J].FoodChem,2007,103:1319.[11]LeeSS,LinHC,ChenCK.Acylatedflavonolmonorhamno2sides,2glucosidaseinhibitors,fromMachilusphilippinensis[J].Phytochemistry,2008,69:2347.[12]TiabouTchindaA,NaharKhanS,FuendjiepV,etal.2Gluco2sidaseinhibitorsfromMillettiaconraui[J].ChemPharmBull,2007,55(9):1402.[13]LamSH,ChenJM,KangCJ,etal.2GlucosidaseinhibitorsfromtheseedsofSyagrusromanzoffiana[J].Phytochemistry,2008,69:1173.[14]AnisE,AnisI,AhmedS,etal.2Glucosidaseinhibitorycon2stituentsfromCuscutareflexa[J].ChemPharmBull,2002,50(1):112.[15]KimJH,RyuYB,KangNS,etal.Glycosidaseinhibitoryfla2vonoidsfromSophoraflavescens[J].BiolPharmBull,2006,29(2):302.[16]IqbalK,MalikA,MukhtarN,etal.2GlucosidaseinhibitoryconstituentsfromDurantarepens[J].ChemPharmBull,2004,52(7):785.[17]GaoH,HuangYN,GaoB,etal.Inhibitoryeffecton2gluco2sidasebyAdhatodavasicaNees[J].FoodChem,2008,108:965.[18]GaoH,HuangYN,GaoB,etal.2GlucosidaseinhibitoryeffectbytheflowerbudsofTussilagofarfaraL[J].FoodChem,2008,106:1195.[19]BabuKS,TiwariAK,SrinivasPV,e

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