葛根的药理学研究及其临床应用进展

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:2001-12-10;:2002-02-22:(1979-),,,97Generalsituationofpharmacologyandclinicalprogressofpueraria1211(11,300162;21,065000);;100825041(2002)0220138203R28516A,18[1]Puerarialobata(Willd.)Ohwi,PueratiaedulisPamp,P.omeiensisWangetTang,P.thomsoniiBenth,P.phaseoloides(Roxb.)Benth,,,,1,:(1),ABC;(2),ABCBA;(3),,221121111,,:[2],,,,,,(VascularSmoothMuscleCell,VSMC)(Arteriosclerosis,AS)[3],21112,:[4],[5],,,,,,,21113,:,,,,,,21114:,,,,212,,[6](500mg/kg),[6]213831(ActaAcademiaeMedicinaeCPAPF)Vol111No12(-OH,O-2),SOD,,,[7],,(bloodalcoholconcentration,BAC),[8,9]BAC[8,10]214P450,[11]P450[7]Wistar,P450[7],P450,[12,13]215,400mg/kg,800mg/kg,1200mg/kg7,;500mg/kg,1000mg/kg42,D-3Ames,,,4,24,calycosin,calycosin;[14],5mg/kg(t[015])(t[015])10137410,(MRT)1128,,,,,,2416%5511,,,,,,[15],,(VBYIV),,,,,[16]512,AMD(age-relatedmaculardegeneration),30min,[17],,26,,,1%,513,,,[15]514,,,,,,6[1],1[J]1,1997,8(5):389.[2]1-[J]1,1980,5(4):208.[3],15[J]931(ActaAcademiaeMedicinaeCPAPF)Vol111No121,2000,23(4):18-20.[4],,,1:[J]1,1975,55(10):7241[5],,,1[J]1,1998,13(3):167-168.[6],1[J]1,1985,20(11):863.[7]GuerraMC,SperoniE,BroccoliM,etal.Comparisonbetweenchi2nesemedicalherbPuerarialobatacrudeextractanditsmainisoflavonepuerarinantioxidantpropertiesandeffectsonratliverCYP-catalyseddrugmetabolism[J].LifeSci,2000,67(24):2997-3006.[8]LinRC,LiTK.Effectsofisoflavonesonalcoholpharmacokineticsandalcohol-drinkingbehaviorinrats[J].AmJClinNutr,1998,68(6Suppl):1512-1515.[9]LinRC,GuthrieS,XieCY,etal.IsofavonoidcompoundsextractedfromPuerarialobatasuppressalcoholpreferenceinapharmacogeneticratmodelofalcoholism[J].AlcoholClinExpRes,1996,21(4)659-633.[10]OverstreetDH,LeeYW,RezvaniAH,etal.SuppressionofalcoholintakeafteradministrationoftheChineseherbalmedicine,NPI-028,anditsderivatives[J].AlcoholClinExpRes,1996,20(2):221-227.[11]JohannesKAM,DepierreJW.MeasurementofcytochromeP450inthepresenceoflargeamountsofcontaminatinghemolglobinandmethemoglobin[J].AnalBiochem,1978,86:725.[12],,,1P450[J]1,2000,16(3):354-355.[13],,,1[J]1,1999,12(1):84-86.[14]KimDH,YuKU,BaeEA,etal.Metabolismofpuerarinanddaidzinbyhumanintestinalbacteriaandtheirrelationtoinvitrocytoto2cixity[J].BiolPharmBull,1998,21(6):628630.[15]1[J]1,2000,31(6):2-3.[16],,1-[J]1,2000,15(15):701.[17]XuanB,ZhouYH,YangRL,etal.Improvementofocularbloodflowandretinalfunctionwithpuerarinanalogs[J].JOcularPharma2cologyTher,1999,15(3):207-216.(:)(133)factorisapotentbiologicresponsemodifierofTcell[J].JExpMol,1991,174:1323-1333.[12]WilsonE,LasterSM,GoodongLR,etal.Platelet-derivedgrowthfactorstimulatesphagocytosisandblocksagainst-inducedactivationoftheneutrophiloxidativeburst:apossiblecellularmechanismtoprotectagainstoxygenradicalchange[J].ProcNatlAcadSci,1999,84:2213-2217.[13]KarlssonCandPaulssonY.Agerelatedinductionofplatelet-derivedgrowthfactorAchainmRNAinnormalhumanfibroblasts[J].JCellphysiol,1994,158:256-262.[14]WinklesJA,OConnorML,andFrieselR.Alteredregulationofplatelet-derivedgrowthfactorA-chainandc-fosgeneexpressioninsenescentprogeniafibroblasts[J].JCellphysiol,1990,144:313-325.[15]MorisS,KawanoM,KanzakiJ,etal.Decreasedexpressionoftheplateletderivedgrowthfactorbeta-receptorinfibroblastsfromapa2tientwithWernerssyndrome[J].EurJClinInvest,1993,23(3):161-165.(:)041(ActaAcademiaeMedicinaeCPAPF)Vol111No12

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