nonsteroidalanti-inflammatorydrugs,NSAIDs)nonsteroidalnonsteroidalantianti--inflammatoryinflammatorydrugs,drugs,NSAIDsNSAIDs))PGEPGE22PGPGnonsteroidalnonsteroidalantiinflammatoryantiinflammatorydrugs,drugs,NSAIDsNSAIDs))COXCOX--22ICIC5050/COX/COX--1IC1IC5050=0.018)=0.018)((COXCOX--2IC2IC5050/COX/COX--1IC1IC5050=0.6)=0.6)PGPGTXATXA22PGIPGI22PGIPGIPGEPGECOXCOX--22COXCOX--11COXCOX--11COXCOX--22AspirinAspirin••••4040mg/d)mg/d)TXATXA22300300mg/dmg/d))PGIPGI22OCOOHCCH3OparacetamolparacetamolphenacetinphenacetinNHCOCH3OC2H5NHCOCH3OHNH2OC2H5indometacinindometacinNCH2COOHCH3H3COCOClIndometacinW.JINW.JINW.JINphenylbutazonephenylbutazoneNNOOCH3(CH2)2CH22nimesulideCOX222nimesulidenimesulideCOXCOX22