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2892002115,,,(,430022)CurrentStatusandKeyTechnologyinTargetingTherapyforCancerXIANGYan,XIAJin2song,LIHong2fa,etal.:,,:;;;:R730.54:A:1004-0242(2002)05-0289-03:2001-10-10;:2002-03-26,,:,,,,10,,,:1,(McAb),McAb,B,,:(1),ADCC;(2),,,,(McAb),,(HAMA),,,,:(ScFv)HAMA,,[1],,(ADEPT),ADEPT,22,[2],(),,,,,;,,,/,,,[3],3,,SD2902002115,,[4,5],:-2;,,,:(AFP),(Tyr)(CEA)(PSA)A(SPA),(ecdysone)RU486,,(hypoxiaresponseelement,HRE)4(ASON),,ASON1525,,,,mRNA,ASON,5,,(cytopathiceffect,CPE),,,,,,;()p53p53,EIB,;p53,,ONXY2015,p53,Reovirus,rasrasreovirus,rasras,reovirusreovirus(HSV2)HSV,,,ONXY2015,,,66.10.1nm100nm,,,,,,,[6],,,,,,[7]6.2:,2912002115[1][2][3][4][5][6][7][8],:,,:,,DMNDMN,,(DMN100%)DMN(20nm100nm),,Kupffer,(),,DMN,,DMN,,,,,,,(DNARNA),,,,,,DMN,[8]:,,,7,,,,,,:BoelE,VerlannS,PoppelierMJ,etal.Functionalhumanmonoclonalantibodiesofallisotypesconstructedfromphagedisplaylibrary2denivedsingle-chainFvantbodyfragments[J].JImmurolMethod,2000,239(2):153-166.ErkkiK,WadihA,DanielR,etal.Identificationofreceptorligandswithphagedisplaypeptidelibraries[J].JNuclMed,1999,40:883-888.PasqualiniR,RuoslahtiE.Organtargetinginvivousingphagedisplaypeptidelibraries[J].Nature,1996,380:364-366BoulikasT.Cancergenetherapyandimmunotherapy[J].IntJOncol,1996,9:941.BarryMA,DowerWJ,JohnstonSA.Towardcell2targetinggenetherapyvectors:selectionofcell2bindingpeptidesfromrandompeptidepresentingphagelibraris[J].NatureMed,1996,2:299-305.MooreA,MarecosE,BogdanovA,etal.Tumoraldistributionoflong2circulatingdextran2coatedironoxidenanoparticlesinarodentmodel[J].Radiology,2000,214(2):568.DavisSS.Biomedicalapplicationsofnanotechnologyimpli2cationsfordrugtargetingandgenetherapy[J].TrendsBiotechnol,1997,15(6):217.JosephsonL,TungCH,MooreA,etal.High2efficiencyintra2cellularmagneticlabelingwithnovelsuperparamagnetic2Tatpeptideconjugates[J].BioconjugChem,1999,10(2):186.,,,;2003,,,,