麻仁软胶囊药理和临床研究进展

吴怡,宋风武,张志奇,李宏*(,300400):,,,,:;;;;;:R285:A:02532670(2010)09157503AdvancesinstudiesonpharmacologyandclinicalofMarenSoftGelatinCapsuleWUYi,SONGFengwu,ZHANGZhiqi,LIHong(TianjinCentralPharmaceuticalCo,Ltd,Tianjin300400,China)Keywords:MarenSoftGelatinCapsule;CannabisSemen;RheiRadixetRhizoma;constipation;antiaging;antioxidation,,,1997,,,,1,!∀,6,!∀,!∀,,!∀!∀,!∀,,,,[12],,;,,,,,[3]22.1:,,,,[4],;,,,,[5],,,SOD,,[6]2.2:,,,,,,[7][8],[9],,cAMP,Cl-K+,#1575#中草药ChineseTraditionalandHerbalDrugs41920109*:20100310*Tel:[phone]Email:[e-mail],[10],,,,[11],,[12],NO,(P0.01),NOSODGSHPx,MDA(P0.01)[13],[14],SODGSHPx,,LPO,,,[15],(1~30mol/L),,,[1617],,(400∃15)min,(600∃24)min,(P0.05),,(8.62∃1.20)/min,,(0.33∃0.05)mV,16.05%,10.58%;,,(23.21∃3.86)/min,,(0.19∃0.03)mV,,10.38%,12.48%Na+K+ATP,Na+,,[18](aquaporins,AQPs),2(AQP2)4(AQP4),,AQP2[1920],,;,AQP2,AQP2mRNA,AQP2,AQP2[21](colonicepithelialcells,CEC)AQP2AQP4,,AQP4,,AQP2AQP4LoVo,LoVoAQP2AQP4LoVoAQP2AQP4,CECAQP2AQP4,[22]Yen[23],BHA(96%)(95%)(93%)(78%)(71%)(36%)(8%)(0.25mg/mL)Fenton26.2%16.6%41.8%,,[24],DPPH,;DPPH,3Yen[23],,,DPPH3,[25]105,90.48%,74.29%(P0.01),,(P0.01),,,#1576#中草药ChineseTraditionalandHerbalDrugs41920109[26],,63.33%,46.67%,2(P0.05);(P0.01);,,,,,[27],,,,[28],,,,,[29],10,[30],95.59%,[31],(P0.05)5HT4,[32],[33]4,,,,,[26],;,SOD,,LPO,,[14][2224],,,:[1],,[J],2005,22(4):5052[2][J],2004,19():301302[3][D]:,2009[4],,,[J],1993,18(4):236239[5],,[J],1992,12(3):4447[6],,,[J],2005,11(5):7374[7]KunzelmannK,MallMElectrolytetransportinthemammaliancolon:mechanismsandimplicationsfordisease[J]PhysiolRev,2002,82(1):245289[8]EweKIntestinalTransportinConstipationandDiarrhoea[J]Pharmacology,1988,36(Suppl1):7384[9],,,[J],2008,24(4):15[10]%%%[J],1993,15(1):1722[11],,,[J],1998,18(5):294295[12],,,NO[J],2004,19(1):2526[13],,,SODGSHPxMDA[J],2004,17(6):910[14],,,[J],2004,19(2):123124[15],[J],2005,25(9):804809[16],,,[J],2005,4(2):108112[17][D]:,2005[18],,,[J],2006(23):19871991[19],,,AQP2[J],2008,33(14):17321735[20][D]:,2008[21]LoVo[D]:,2008[22]ztrkM,ztrkFA,DuruME,etalAntioxidantactivityofstemandrootextractsofRhubarb(Rheumribes):Anediblemedicinalplant[J]FoodChem,2007,103(2):623630[23]YenGC,DuhPD,ChuangDYAntioxidantactivityofanthraquinonesandanthrone[J]FoodChem,2000,70(4):437441[24],,,[J],2010,41(3):412415[25],,,105[J],2002,10(15):78[26],,,[J],2009,4(6):445447[27][J],2009,40(11):17911792[28],,[J],2009,40(5):781782[29],[J],2009,38(12):11461147[30][J],2009,2(5):1720[31],,[J],2004,16(3):107[32],,90[J],2007,27(1):3031[33],[J],2005,11(6):583584#1577#中草药ChineseTraditionalandHerbalDrugs41920109