基底前脑结构和功能概述

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Nov.200521(6)683686(ChineseJournalofNeuroanatomy)3(,230032)(basalforebrain,BF),BF,:[1,2]BF,:BF,BF[3,4],BF,BF1.1896kolliker-1946Brockhaus,(substantiainnomi2nataSI)BF,Heimer,[5]BF(1):(1)(MS)Broca(VDB)(HDB)(MPA)Meynert;(2)(VS2VP),,;(3),Heimer,HDB,,[6]Meynert1.1MSHDB/VDBMPAnbM,:,MS,,;,,VDBHDB,HDBMey2nertnbMMeynert,kolliker,,MS2VDB2HDB2nbML,:nbM();MS;/:nbM;521.2,Heimer1973,,,,2Maurice[7]2-,,1:,(No.30470904)3:055123220286E2mail:guangwuli@sina.com.cn1(deOlmas[6]):;(),()2()1.31923,Johnston(bednucleusofthestriatermina2lisBST),50deOlmas2,,,,BSTBST,,Heimer[5]:2;2,(interstitialnucleusofthepos2teriorlimboftheanteriorcommissureIPAC)IPAC,IPAC,-BST:,,:,,,,[6]2.BF,2.1AchGABA2.1.1ACh(1967),:Ch1-,10%,Ch22VDB,70%,Ch32HDB,1%,Ch42nbM,90%,BF,BF-222,BF,BF,BF[8]2.1.2GABA2080GABA,MS,GABA,2GABA,GABA,GABA,,GABA,REM[2](2)2.1.3,,ACh,,4862162005112(KazueSemba[2])ACh[9]YPB[10]2.1.4-3[11],p75,BFp75BFNGFmRNAGABA[12,13],GABA2.2,GABAEAASPENK,,GABADAGABA,P(D228K)[14,15],,,2.3ENKSP,DAGABAEAA()BF,,BF,,BF,BF,BFAChGABABF,,,,,586:,,(2005-03-08)[1]Berger2SweeneyJ,StearnsNA,FrickKMetal.Cholinergicbasalforebrainiscriticalforsocialtransmissionoffoodpreferences.Hip2pocampus,2000;10:729-738[2]SembaK.Multipleoutputpathwaysofthebasalforebrain:organiza2tion,chemicalheterogeneity,androlesinvigilance.BehavBrainRes,2000;115:117-141[3]RicceriL,MinghettiL,MolesAetal.Cognitiveandneurologicaldeficitsinducedbyearlyandprolongedbasalforebraincholinergichypofunctioninrats.ExpNeurol,2004;189:162-172[4]CarelliRM,WightmanRM.Functionalmicrocircuitryintheaccum2bensunderlyingdrugaddiction:insightsfromreal2timesignalingduringbehavior.CurrOpinNeurobiol,2004;14:763-768[5]Heimer,L.Thelegacyofthesilvermethodsandthenewanatomyofthebasalforebrain:Implicationsforneuropsychiatryanddruga2buse..ScandJPsychol,2003;44:189-201[6]deOlmasJS,HeimerL.Theconceptsoftheventralstriatopallidalsystemandextendedamygdala.AnnNYAcadSci,1999;877:1-32[7]MauriceN,DeniauJM,MenetreyA.Prefrontalcortex2basalgangliacircuitsintherat:involvementofventralpallidumandsubthalamicnucleus.Synapse,1998;29:363-370[8]KazueSemba.Phylogeneticandontogeneticaspectsofthebasalforebraincholinergicneuronsandtheirinnervationofthecerebralcortex.ProgBrainRes,2004;145:3-43[9]EspanaRA,ReisKM,ValentinoRJetal.Organizationofhypocre2tin/orexinefferentstolocuscoeruleusandbasalforebrainarousal2relatedstructures,JCompNeurol,2005;481:160-178[10]GrittiI,MannsID,MainvilleLetal.Parvalbumin,calbindin,orcalretininincorticallyprojectingandGABAergic,cholinergic,orglutamatergicbasalforebrainneuronsoftherat.JCompNeurol,2003;458:11-31[11]YuharaA,IshiiK,NishioCetal.PACAPandNGFcooperativelyenhancecholineacetyltransferaseactivityinpostnatalbasalfore2brainneuronsbycomplementaryinductionofitsdifferentmRNAspecies.BiochemBiophysResCommun,2003;301:344-349[12]TremereLA,PinaudR,GroscheJetal.Antibodyforhumanp75LNTRidentifiescholinergicbasalforebrainofnon2primatespecies.Neuroreport,2000;11:2177-2183[13]LauterbornJC,BizonJL,TranTMetal.NGFmRNAisexpressedbyGABAergicbutnotcholinergicneuronsinratbasalforebrain.JCompNeurol,1995;360:454-462[14]KombianSB,AnanthalakshmiKV,ParvathySSetal.Cholecysto2kinininhibitsevokedinhibitorypostsynapticcurrentsintheratnu2cleusaccumbensindirectlythroughgamma2aminobutyricacidandgamma2aminobutyricacidtypeBreceptors.JNeurosciRes,2005;79:412-420[15]LimMM,MurphyAZ,YoungLJ.VentralstriatopallidaloxytocinandvasopressinV1areceptorsinthemonogamousprairievole(Mi2crotusochrogaster).JCompNeurol,2004;468:555-570686216200511

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