ST2与心力衰竭的研究进展-信秀明

20153223JournalofPracticalMedicalTechniquesMarch2015Vol.22No.3ST2山东省商河县中医院（251600）信秀明潍坊医学院附属文登中心医院刘鹏涛别自东ST21989。2005IL-33Schmitz[1]IL-33ST2。ST2/IL-33、[2-4]、、[5]HF、AMI[67]。ST2、IL-33。1ST21.1ST2、ST2。ST2HUGOIL-1IL1-RToll/IL-1TIRIL1-R/Toll。NF-κBMap[8]。ST24sST2、ST2L、ST2VST2LV。sST2ST2、、ST2LST2TTh2IL1-RST2VST2LVST2ST23C1ST2VST2V、、、、、ST2LST2LV。1.2ST2ST2、。ST2。sST2IL-33IL-33/ST2。sST2。Shimpo[9]ST2AMI。2ST2/IL-33IL-33IL-33ST2IL-1、886NF-κBMapTh2IL-4、IL-5。。sST2IL-33ST2/IL-33。3ST2ST2ST2。sST2BNP。Januzzi[10]5931sST21sST20.23ng/mLsST2111sST245%sST215%。Rehman[11]346ST2、、BNP、BNT-proBNP、、。BNP、NT-proBNPST2BNPNT-proBNP。Mueller[12]137sST2141。sST2sST21sST2700ng/L1。4ST2、Shah[13]ST2sST2、。PRIDEsST2。sST2、、P=-0.18P=0.046、P=0.26P=0.005。ST2t=2.29P=0.002t=2.15P=0.05t=2.57t=2.98P0.05NT-proBNPt=3.31P=0.009t=2.59P=0.01t=2.00P=0.05。[e-mail]273··20153223JournalofPracticalMedicalTechniquesMarch2015Vol.22No.3。ST24t=2.70P=0.003。5、ST2150[14]sST290dNT-proBNP。sST2＞15.5%7%sST233%。sST290dBNP。sST2。PROTECTsST2、-15sST2。sST2。、、sST2BNP。sST2BNP、。sST2sST2。6ST2ST2sST2、AMI。ST2。Sanada[15]ST2/IL-33sST2IL-33ST2/IL-33。IL-33NF-κBIL-33。7ST2AHAABC/D。A、B、CD。。Weir[16]ST2。AMI＜40%contrast-enhancedcardiacmagneticresonanceceCMR1224。sST2、。sST224、infarctvolumeindexceCMRceCMRsST2AMI。Shimpo[9]ST2ST2。Sabatine[17]CLARITY-TIM-281239STSTEMIST2sST23.5。1200STEMIsST2、、sST2STEMI30d[917]AMINT-proBNP[18]。ST2/IL-33。sST2IL-33、。ST2/IL-33。[1]SchmitzJOwyangAOldhamEetal．IL-33aninter-leukin-1-likecytokinethatsignalsviatheIL-1receptor-relatedproteinST2andinducesThelpertype2-associatedcytokines[J]．Immunity2005235479-490.[2]FousterisEMelidonisAPanoutsopoulosGetal．Toll/inter-leukin-1receptormemberST2exhibitshighersolublelevelsintype2diabetesespeciallywhenaccompaniedwithleftventriculardiastolicdysfunction[J]．CardiovascDiabetol201110101．[3]CarriereVRousselLOrtegaNetal．IL-33theIL-1-likecytokineligandforST2receptorisachromatin-associatednuclearfactorinvivo[J]．ProcNatlAcadSciUSA20071041282-287．[4]SweetMJLeungBPKangDetal.Anovelpathwayregulatillglipopolysaccharide-induedshockbyST2/T1viainhibitionoftoll-likereceptor4expression[J].JImmunol20011666633-6639.[5]SanadaSHakunoDHigginsLJetal．IL-33andST2compriseacriticalbiomechanicallyinducedandcardioprotectivesignalingsystem[J]．JClinInvest200711761538-1549．[6]SabatineMSCannonCPMichaelGibsonCetal．AdditionofclopidogreltoaspirinandfibrinolytictherapyformyocardialinfarctionwithST-segmentelevation[J]．NEnglJMed20053521179-1189．274··20153223JournalofPracticalMedicalTechniquesMarch2015Vol.22No.3山西医科大学（030001）张跃武张辉郭兴华hemorrhagictransformationHT。CT、MRIHT。HT。1HT1986OttHTCTCT。、。[1]CTHT4①②③④。ECASS[2]CTHT2hemorrhagicinfarctionHIparenchymalhematomaPH。2HI1HI2PH130％PH230％。。CTCTHI1。MRICTMRIHT。MRI[3]HTHTHT3。HTMRIHTHTMRI。2HT2．1CT2．1．1CTCTMRI[7]MuellerTDieplingerBGegenhuberAetal.IncreasedplasmaconcentrationsofsolubleST2arepredictivefor1-yearmortalityinpatientswithacutedestabilizedheartfailure[J].ClinChem2008S4752-756.[8]AliSHuberMKolleweCetal．IL-1receptoraccessoryproteinisessentialforIL-33-inducedactivationofTlympho-cytesandmastcells[J]．ProcNatlAcadSciUSA200710418660-18665．[9]ShimpoMMorrowDAWeinbergEOetal.Serumlevelsoftheinterleukin-1receptorfamilymemberST2predictmortalityandclinicaloutcomeinacutemyocardialinfarction[J].Circulation20041092186.[10]JanuzziJLJrPeacockWFMaiselASetal.MeasurementoftheinterleukinfamilymemberST2inpatientswithacutedyspnearesultsfromthePRIDEstudy[J].JAmCollCardiol200750607-613.[11]RehmanSUMuellerTJanuzziJLJr.CharacteristicsofthenovelinterleukinfamilybiomarkerST2inpatientswithacuteheartfailure[J].JAmCollCardiol2008521458-1465.[12]MuellerTDieplingerBGegenhuberAetal.IncreasedplasmaconcentrationsofsolubleST2arepredictivefor1-yearmortalityinpatientswithacutedestabilizedheartfailure[J].ClinChem200854752-756.[13]ShahRVChen-TournouxAAPicardMHetal.Serumlevelsoftheinterleukin-1receptorfamilymemberST2cardiacstruc-tureandfunctionandlong-termmortalityinpatientswithacutedyspnea[J].CircHeartFail20092311-319.[14]BoisotSBeedeJIsaksonSetal.SerialsamplingofST2predicts90-daymortalityfollowingdestabilizedheartfailure[J].JCardFail200814732-738.[15]SanadaSHakunoDHigginsLJetal.IL-33andST2compriseacriticalbiomechanicallyinducedandcardioprotectivesignalingsystem[J].JClinInvest20071171538-1549.[16]WeirRAMillerAMMurphyGEetal.SerumsolubleST2aPotentialnovelMediatorinleftventricularandinfartremodelingafteracutemyocardialinfaretion[J].JAmCollCardiol201055243-250.[17]SabatineMSMorrowDAHigginsLJetal.ComplementaryrolesforbiomarkersofbiomechanicalstrainST2andN-terminalprohormoneB-typenatriureticpeptideinpatientswithST-ele-vationmyocardialinfarction[J].Circulation20081171936-1944.[18]SabatineMSCannonCPMichaelGibsonCetal．AdditionofclopidogreltoaspirinandfibrinolytictherapyformyocardialinfarctionwithST-segmentelevation[J]．NEnglJMed20053521179-1189．（收稿日期：2014-10-21）275··