医用粘合剂的发展及临床应用进展

王艳红1,顾汉卿2,,,;;:R318.08:A:10050809(2008)03002310DevelopmentandClinicalApplicationofMedicalAdhesiveWANGYanhong,GUHanqing(1.TianjinMedicalUniversity,Tianjin300070,China)(2.TianjinInstituteofUrologicalSurgery,Tianjin300211,China)AbstractMedicaladhesiveisakindofbiomaterialwithnotonlygeneralfunctionofadhesive,butalsospecialbiomedicalfunction.Accordingtotheircomposition,thedevelopmentandclinicalapplicationoftissueadhesive,dentaladhesiveandosseousadhesiveareintroducedinthisarticle.Keywordsmedicaladhesive;agglutinate;clinicalapplication,,,,,,3000,,,,[1]:(1)();(2),;(3);(4);(5);(6),;:1.300070,2.300211,:,Emai:[e-mail]!23!20089(19)3(7);(8);(9),;,[1],,:(MAP),[2]11.11949B.F.GoodrichArdisA.E,[2],1958EastmanKodark(CA)Eastman910[3]1962,[4]2070,508J1J2J311,2080[5][6]1,2,,,,1.2:R1~16,:-CN-COOR,,,(),,,,,[45],,-NH2-COOH,[7]1.31.3.1,6~15s,;;,;,,,1.3.22.1J,[8];,[9],:LD5013g/kg,;;,[10],,,Nesburn:,,,[11]AxelNitsch[12]:,,[13],[14][15],,,,,[16],Maw[17],,,!24!CHINESEJ.DIAL.&ARTIF.ORGANSVo.l19No.3SEP.2008,,,,,Schwann,T[18]ToriumiDM[19]:,:,;,,,,,,,1.5,,,1.5.1,,,[17],,,,[20],,(),,[21],,,,,,[22],,,[23],2830%[14],,[25]1.5.2,[25],,,,,[26],,,,[27],,,,,,;,;,[28]Laurie,,,,5,[29],,,[30],,[31]Moschos[32]10.08.0,3mm,,1.5.3,-,,,,[34]JulianE[34],NozomiSugimoto[35],!25!20089(19)3,Kiesselbach,[36]1.5.4,,,(NBCA),NBCA,,,,[37],NBCA,,2,NBCA[38]NBCA,-,[39]Peter[40],,,OkudaIII,DefreyneL[41]KIYOSHISAKAMOTO[42]P.Barillari[43],,,,,,,,[44],,,∀#,[38]∀#,,,,[45]1.6,,,,,,,,[16],[46],,,(AVM),,[47],,[18],,,,[31],,2,,,8,10~12ToriumiDM,1.7,,,,,,,,,2(fibringlue)(fi!26!CHINESEJ.DIAL.&ARTIF.ORGANSVo.l19No.3SEP.2008brinsealan,tFS),,20,1909,Bergal[50]2070,Matras,20,,[48]2.1,,;∃,,,;,[49]2.2,,,,,,,,,,,,[50],,,,,2.2.1,208020,,[51],[52],,,,,[53],,[54],,,,,[55],[56]2.2.2,:,,,,,,,[57]2.2.3,,[58][59],,,,,,[60]2.2.4,2090,Songer[61]:∀#,,,,[62],,,,,[63],!27!20089(19)3[64],,,,31965Newman[65],,,,,3.1,,,,,,,,[66]3.2:(cements)(resin)(resincementhybridmaterial),,,[67],[68],,,,,,,,,[67]3.3,,,,[69]:3.3.1,,,,,[70],,[71],,[72],,,[73],,,[74],[75],,,,[76]3.3.2,,,,,,,,,,,,,[77]3.3.3,,,,,[78][79],,;,!28!CHINESEJ.DIAL.&ARTIF.ORGANSVo.l19No.3SEP.2008:4:1979Charnley(PMMA);1985BrownChowCPC(CalciumPhosphateCement)[80]PMMA,,[4],,,,,,,[5]1991(FDA)[81],[82],,,,[83],,,,,,[84](TCP)(TTCP),(HAP)(DCPD)(CaCO3)(CaO),(CaSiO3),1.506,,CPC,,,Carey[85]CPC,,5,:[86],,,,,,,,,,,,,[87],[88],,[92],,,,,,,,[90](PVP),,,,,,,,,,6,,,,,,,,,;,,,,!29!20089(19)3,,[1],,,.[J].,2003,31(4):912.[2],.[J].,2004,4(4):690694.[3],.[J].,2004,13(2):4045.[4],,.[J].,2001(1):2122,28.[5],,.[J].,2002,23(1):2831.[6],,,.:1,2[J].,1993,2(1):20.[7],,.[J].,2001,5:215218.[8],,,.EC[J].,2004,22(5):400.[9],,,.[J].,1998,14(3):178179.[10],,.[J].,2004(7):47.[11]RefojoMF,DohlmanCH,KoliopoulosJ.Adhesiveinophthalmology:areview[J].SurveyofOphthalmology,1971,15(4):217236.[12]NitschA.Cellular,histomorphologic,andclinicalcharacteristicsofanewoctyl2cyanoacrylateskinadhesive[J].AestheticPlasticSurgery,2005,29:5358.[13],,,.[J].,2002,11(3):4752.[14],,.[J].,2007,29(8):581583.[15],,,.[J].,2006,10(17):5153.[16],.[J].,2004,4(4):690694.[17]MawJL,KartushJM.Ossicularchainreconstructionusinganewtissueadhesive[J].TheAmericanJournalofOtology,2000,21(3):301305.[18],,,.[J].,2006,27(5):450451.[19]ToriumiDM,RaslanWF,FriedmanM,eta.lHistotoxicityofcyanoacrylatetissueadhesives.Acomparativestudy[J].ArchivesofOtolaryngology!Head&NeckSurgery,1990,116(5):546550.[20]HugkulstoneCE.Changesinkeratometryfollowingtrabeculectomy[J].BritishJournalofOphthalmology,1991,75(4):217218.[21].[J].,2007,16(1):8386.[22],,.[J].,2005,21(2):7478.[23]SebestaMJ,BishoffJT.Octylcyanoacrylateskinclosureinlaparoscopy[J].JournalofEndourology,2003,17(10):899903.[24]VargasG,RegerTB.Analternativetosutures[J].PlasticSurgeryNursing,2001,21:8385.[25]DavisSC,EaglsteinWH,CazzanigaAL,eta.lAnoctyl2cyanoacrylateformulationspeedshealingofpartialthicknesswounds[J].DermatologySurgery,2001,27(9):783788.[26]AksoyM,TurnadereE,AyalpK,eta.lcyanoacrylateforwoundclosureinprostheticvasculargraftsurgerytopreventinfectionsthroughcontamination[J].SurgeryToday,2006,36(1):5256.[27],,,.[J].,2002,16(3):158160.[28],.[J].,2007,23(4):591592.[29]BernardL,DoyleJ,FriedlanderSF,eta.lAprospectivecomparisonofoctylcyanoacrylatetissueadhesive(dermabond)andsuturefortheclosureofexcisionalwoundsinchildrenandadolescents[J].ArchivesofDermatology,2001,137:11771180.[30]GonzalezE,Ethyl2cyanoacrylatefixationofthecranialboneflapaftercraniotomy[J].SurgicalNeurology,2000,53(3):288289.[31],,,.[J].,2007,23(16):24752477.[32]MoschosM,DroutsasD,BoussalisP,eta.lClinicalexperiencewithcyanoacrylatetissueadhesive[J].DocumentaOphthalmologica,1997,93(3):237245.[33],,,.a[J].,2006,18(7):442444.!30!CHINESEJ.DIAL.&ARTIF.ORGANSVo.l19No.3SEP.2008[34]LosanoffJE,RichmanBW,JonesJW.Cyanoacrylateadhesiveinmanagementofseverepresacralbleeding[J].DiseaseoftheColon&Rectum,2002,45(8):11181119.[35]SugimotoN,WatanabeK,WatanabeKazuyo,eta.lEndoscopichemostasisforbleedinggastricvaricestreatedbycombinationofvaricealligationandsclerotherapywithNbutyl2cyanoacrylate[J].JournalofGastroenterology,200