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PharmaceuticalBiotechnology2014213274～278*250012、、。。。、、。TQ433A1005-8915201403-0274-05。、、、、1。。。1123、、45。。、、4。3、。11.11.1.120。1909Bergel。1972MatrasVIII1-2。。2090。SFDA19983。2080。1994。1999。、、。1.1.2。、VIII、CaCl2。XIII1。。1.1.3。。。472*2013-05-042013-07-031989-E-mailluojie_890117@126.com。*0531-88382658fswang@sdu.edu.cn。2008ＲecothromSFDA。。、“”4-5。1.1.4。。。、、、。1.1.4.1Saha1。140。4min。62.9%4min31.4%。6。1.1.4.2Kim3441441220067。1.21942Frantz8。SurgicelpH。SurgicelSurgicelpH。HemConChitoFlex。9。10。22.1--GＲF2.1.11964BraunwaldTatooles--GＲF。1977Bachet。GＲFA11。GＲF。12。GＲF。GＲF。2.1.2GＲF--。、。2.1.3GＲFGＲF。GＲF。Bingly67GＲFA22712GＲF13。Suzuki269A222GＲF47GＲF12.6%31.9%GＲF。1～653116%24GＲF14。2.2BioGlue2.2.1BioGlueCryoLife2090。199820012010BioGlue。19986CryoLifeBioGlueA。BioGlueCryoLifeBioGlueHDE199912SFDA。200112SFDABioGlue57221315。BioGlue。2.2.2BioGlueBSAGA。BSA。45%BSA10%GA4∶116-17。BioGlueBSA583GAGABSAGABSA、GA、18。2.2.3BioGlue1BioGlue2BSAGA20～30s2min3BioGlue19-204BioGlue。BioGlue。BioGlueBioGlue。BioGlue21。2.2.4Weiner99742587BioGlue12GＲF。785127BioGlueGＲF。BioGlue1～90。BioGlue13.9%BioGlue4.0%。BioGlueGＲFBio-Glue22。2.3。23%0.12%400mmHg200mmHg23。。24。-L-。-L--L-。。25℃。-L-。-L-。-L-。。33.1α-3.1.1194925。1958EastmanKodarkα-Eastman910125。α-。19622070508。α--12-26。。。、、、、27。6723.1.2α-。α--CN-COOＲβ-。、。3.1.3α-1。。α-。2。3。1227。3.23.2.1PEGPEG。PEG。DuraSeal。DuraSealN-PEG4～8w。CoSealPEG。FocalSealPEG28。。3.2.2。-L--L-30s4d。429。。。。Tony60s。、30。4。、BioGlue、、GＲF、。BioGlue、GＲF。、、。1．J．200819323.2．J．20121827.3SpotnitzWD．FibrinsealantpastpresentandfutureabriefreviewJ．WorldJSurg2010344632.4KesslerCMOrtelTL．ＲecentdevelopmentsintopicalthrombinsJ．JThrombHaemost2009102115.5BurnoufT．ＲecombinantplasmaproteinsJ．VoxSang2011100168.6SahaSPMulukSSchenkWetal．Aprospectiverandomizedstudycomparingfibrinsealanttomanualcompressionforthetreatmentofanastomoticsuture-holebleedinginexpandedpolytet-rafluoroethylenegraftsJ．JVascSurg2012561134.7KimKParkSLKimBJetal．Efficacyoffibrinsealantinreduc-inghemorrhageafteraloopelectrosurgicalexcisionprocedureJ．GynecolObstetInvest20127411.8ＲyanMHardeanEDavidMetal．AcomprehensivereviewoftopicalhemostaticagentsefficacyandrecommendationsforuseJ．AnnSurg20102512217.9KunioNＲＲihaGMWatsonKetal．Chitosanbasedhemostaticdressingisassociatedwithdecreasedbloodlossinaswineuncon-trolledhemorrhagemodelJ．JAmCollSurgeons2012215354.10XieHKhajancheeYSJeffreySetal．Useofachitosan-basedhemostaticdressinginlaparoscopicpartialnephrectomyJ．JBi-omesMaterＲesB200885B1267.11ImotoK．Ｒecentstatusofgelatin-resorcin-formalinglueforacute772213typeAaorticdissectionJ．GenThoracCardiovascSurg2011595313.12FreemanLEBBlairALubinJHetal．Mortalityfromlymphohe-matopoieticmalignanciesamongworkersinformaldehydeindus-triestheNationalCancerInstituteCohortJ．JNatlCancerInst200910110751.13BingleyJAGardnerMAStaffordEGetal．LatecomplicationsoftissuegluesinaorticsurgeryJ．AnnThoracSurg20006961764.14SuzukiSImotoKUchidaKetal．Aorticrootnecrosisaftersur-gicaltreatmentusinggelatin-resorcinolformaldehydeGＲFglueinpatientswithacutetypeAaorticdissectionJ．AnnThoracCardiovas2006125333.15GruberSMikaKBeneschT．Acomparisonofabovinealbumin/glutaraldehydeglueversusfibrinsealantforherniameshfixationinexperimentalonlayandIPOMrepairinratsJ．SurgEndosc201024123086.16AKaratzasIZachosVTzortzisetal．Useofhaemostaticglueforfistulapreventionafteriatrogeniccombinedruptureofanteriorva-ginalwallbladderandurethraduringvaginaldeliveryJ．JOb-stetGynaecolＲe2011317670.17BiggsGHafronJFelicianoJetal．TreatmentofsplenicinjuryduringlaparoscopicnephrectomywithBioGlueasurgicaladhe-siveJ．Urology2005664882.18JonesEdwardLBurlewCetal．BioGluehemostasisofpenetrat-ingcardiacwoundinproximitytotheleftanteriordescendingcoronaryarteryJ．JTraumaandAcuteCareSurg2012723796.19LouieMKJosephAKhosraviAetal．Bovineserumalbuminglutaraldehydeforcompletelysuturelesslaparoscopichemine-phrectomyinasurvivalporcinemodelJ．JEndourol2010243451.20ＲathinamSNaiduBVNanjaiahPetal．BioGlueandperi-stripsinlungvolumereductionsurgerypilotrandomisedcontrolledtrialJ．JCardiothoracSurg2009437.21GaberelTBorgeyFThibonPetal．Surgicalsiteinfectionasso-ciatedwiththeuseofbovineserumalbumin-glutaraldehydesurgi-caladhesiveincranialsurgeryacase-controlstudyJ．ActaNeurochir20111531156.22WeinerJWidmanSGolekZetal．Ｒoleofbovineserumalbu-minglutaraldehydeglueintheformationofanastomaticpseudoan-eurysmsJ．JCardSurg201126176.23SuzukiSIkadaY．Sealingeffectsofcross-linkedgelatinJ．JBiomaterAppl201327780124LeMaireSACarterSAWonTetal．ThethreatofadhesiveembolizationBioGlueleaksthroughneedleholesinaortictissueandprostheticgraftsJ．AnnThoracSurg2005801106.25．J．2013422184.26．α-12J．19932120.27LeggatPASmithDＲKedjaruneU．Surgicalapplicationsofcya-noacrylateadhesivesareviewoftoxicityJ．ANZJSurg2007774209.28ArtziNShazlyTCrespoCetal．Characterizationofstaradhe-sivesealantsbasedonPEG/dextranhydrogelsJ．MacromolBiosci200998754.29TakaokaMNakamuraTSuqaiHetal．SuturelessamnioticmembranetransplantationforocularsurfacereconstructionwithachemicallydefinedbioadhesiveJ．Biomaterial200829192923.30VuocoloTHaddadＲEdwardsGAetal．Ahighlyelasticandadhesivegelatintissuesealantforgastrointestinalsurger