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20064372FujianJoornalOfCMTApdl2006,37(2)··CA,(,350004:;;;:R259417:B:1000338X(2006)02000603(RA)(A-MI),(I/R),(VT)(VF)。,、,,(PTC)ARA。RA,,RA。,,.,:2001720059180,:①0.512;h②2sT,0.1mv,.02m;V③。3,(HDS)J、(LDSJ)(CTR),1。3(0.05)。13()n()℃A(h)ō`UHDsJ65422361.315.4LDsJ6240226()811.3CTR53322163.713.010.21.729.932.119.801.23l4l5l2,ù、ù.l2`ù..,.2:300mg500mg(300m。、ACIE、p、。PTCA(),3;PTCA5,3,27;dCA,。,,3:,,。RA。RA。RA:①(SB):45/min,Zmin;②(S)A:Zmin;③(AVB):n2111,2min;④(VP):VP(5/min)vP;⑤(vT);⑥(vF);⑦:200512:(1970),,,。(AIR)。7d4,(SOD)、(LPO)。SOD,。LPOTBA,。,.4:,t,,0.05,P.0ol。2,(LMCA)7,(LAD)90,(LCx)29,(RCA)54;144,36;、、(97.5%)(LCA);81.7%RCA,183%LCX;74.6%LCX,25.4%RCA。3LAD,2:CA46.15%、54.84%49.01%。2。3(P0.05)。23HDJSLDSJCTRLMCALDALCXRCAl3l3l0`O」ù440212,.1,.129000420J、à`22J,`,Jù6`U」PTCARA85,RA4.722%,、、,58,3.222%。、、,27,15%。3。33nRA(%)(%)vPvTVFIAR(%)SBAvBSAsAB2`44447ll00114UHDsJ65LDSJ62CTR5333.851)2)53.235.66021.541)37.103.9626321012.3116.131698:CTR,l)P0.05;)L[SJ,2)P0.05、;。28,19,9,120min。203,8。2,1,1。27or,17。1CA52h,2。PTCA3SOD、LPO4。43PTCASOD、LPOt`)SOD()HDSJLDSJCTR248.52135.24256.4128.65253.59144.26150.6661,541)239.61128.132)280.2290.561)2)3)5.921.465831.435.871387,421.261)6441.824.531.131)2)3)656253:,1)P.005;CRT,2)0.05;LDSJ,3)P053SOD、0。,CTRSOD,LPO;HDSJSOD,LPO(0.05);LDSJSOD、0(P.005)。HDsJCTR,SOD,LPO(.005);LDSJCTR,SOD.005),O(p0.05);HDSJLDSJ,SOD,LPO(P.005)。3,,,,,,,,。,①CA,,6824%,,3.294%。②、,,。③,,,。37,,。(),。,,;,;,,。,SOD、、C。,,0,SOD,、RA。,、。、、,、131。}、,,,,l’J。《》“”。,,,,。,。、RA,(LDH),(vLED)Pdpd/tmax,l9J。10I],,,,。。,,ETBZ、6ketoPGFla。。11’,12],,NO,SODMDA,,。l3IJ,,GSHGSH-xP、SOD,MDA。“,”,“,”。《》“,”,。lqI,,,。lqI,LPO,SOD,NO。,,。,!,,NO,。LDSJSOD,O,,,RA,RA。HDSJSOD,O,。,HDSJRA,,,,。CARA,,,AMI,、,。:HeasreDJ.Refursionindueediu:apossibleorleforoxdantsterssanditsamnipulatioJ』.CadriovacsDurTher,1991u12):225.[2]BolliR.oxygendeirvdefereadriealsandmycoadlialreePfrusioninjuanovevriewCadrivoaseDurhTer,1991,5(suppl2)249.13),,..,2X()2,33(l):89·4I].MI.j:,1983.124.5I].IM.]:,1987.300.l6],,.lJ].,1997,6(5):222224.7[],,.〔J].,1994,14(6):.518],,,,IJ].,2),20(7):540.191,,,.lJ[.,1999,(5):13.〔10],,,..,2001,17(1):58.I[11,,,.18pjJ[,1990,11(5):46.6l[2],,.MDA、SOD、ETNOIJ].,1998,18(11):688.l[3],,,.,1995,20(5):4.14][J].,1990,11(1):42.l[51,,,.IJ].,2X()o,17(4):323.