04-Unit-Three2014

UnitThreePharmacologyLiumin2012-03LOGOPart1TextATextCHomeworkUnitThreePharmacologyLOGO(I)drugaccumulation药物蓄积drugdependence药物依赖性druginteraction药物相互作用drugmetabolism药物代谢drugreceptor药物受体druginduceddisease药源性疾病LOGO(II)durationofaction作用持续时间first-passeffect首过效应first-orderkinetics一级动力学generalaction全身作用GCP临床实验规范LOGO(III)localaction局部作用medianeffectivedose(ED50)半数有效量medianlethaldose(LD50)半数致死量minimaleffectivedose最小有效剂量minimaltoxicdose最小中毒剂量modeofaction作用方式LOGO(IV)sideeffect/untowardreaction副作用steadystateplasma血浆concentration稳态血药浓度symptomatictreatment对症治疗targettissue靶组织therapeuticdrugmonitoring(TDM)治疗药物检测tolerance耐受性LOGOPharmacokinetics/Pharmacodynamics药动学、药效学Excretion排泄Doseinterval计量间隔Lipidsolubility脂溶性Parameter参数SpecialTerms(V)LOGOParagraph1DefinitionandcharacterofpharmacokineticsParagraph2-7IntroductiontobasicconceptsconsideringthreeclinicaldosingsituationParagraph8-14LOGOhit-and-run命中后逃逸（的药物）constant-rateintravenousinfusion恒量静脉输注bolus-doseinjection推注repeateddosing多次给药one-compartmentmodel一房室模型NotesP97LOGO课堂练习3摘要练习3LOGOParagraph1DefinitionandclassificationofadversedrugreactionsParagraph2TypeAreactionsParagraph3TypeBreactionsParagraph4&5&6&7TypeC,DandEreactionsLOGOmimics模拟物withdrawalsyndromes截断综合症malnutrition营养不良NotesP105LOGO课堂练习4LOGOReviewthevocabularyandphrasesReadUnitsixtext＆supplementaryLOGO