桑叶的化学成分_药理活性及应用研究进展_邹盛勤

pp桑叶的化学成分药理活性及应用研究进展X邹盛勤,陈武(,336000):N-,,:;;;:S789.4:A:1005-3433(2003)01-0022-04,(MorusalbaL.)16,11,,[1],[2],1,3~7m,,,,,;,5~10cm,20cm,5~11cm,,,;1.5~4cm;,,;,;;4;4;,2,,,,,1~2.5cm,,4~56~7[1]22.1黄酮及黄酮苷类-3-[3]2.2甾类成分B-B-B-D-[1,3]2.3挥发油成分,[1,3]2.4糖类[1]2.5氨基酸类17C-226mgP100g,,C-,2323mgP100g[4]#22#2003371X:(1970-),,,,,2.6维生素类AB1B2C(retinol)[1,3]2.7微量元素[1,3]2.8生物碱成分,(totalpolysaccharideofMorus,TPM)[5],,[6]Asano6,[7]Kimura6SIZ,,N-MeDNJ(N-methy-ldeoxynojirimycin)GAL-DNJ(2-O-d-D-galacTopyranosy-lDNJ)fagomine,GAL-DNJfagomine[8]GAL-DNJ,,,,co-rosolmaronA[9]33.1降血糖作用(TPM),ip(50,100,200mgPkg),,TPM(P0.01);TPM,,TPMB[5],[8](WBNPKob),3,Ñ,ÒÓ,6~46,Ñ40,4618.72mmolPL,Ò2.5%,468.53mmolPL,Ó5%,466.33mmolPL,DNJ(1-deoxynojirimycin)A-,DNJ2-,,,(GTT),,,[10]Asano6N-,[7]KimuraMN-STZ,,:N-Me-DNJGAL-DNJfagomine(300mmolPkg)(30LmolPkg),GAL-DNJfagomine,fagomine(3mmolPL)(8.3mmolPL),4,GAL-DNJ(3mmolPL)fagomine,,GAL-DNJ2-[8],50%#23#2003371(ME),ME(0.1%),ME,(sucrase)[11],(55%),7Wistar,100,101mgPkg,,30~120min50%20%7%,(),[12]ItoDNJDNJ,,DNJDNJ[13]HosseinzadehH,,[14]Lee,A-[14]3.2对心血管系统的作用,,[1]3.3对血脂的影响10mgPkg,,-,[1],[4]3.4抗炎作用S-,,[1]3.5解痉抗溃疡作用,,,5~10mgPkg,[1]44.1中药材应用56,,,,,,,[2],,,,,4.2开发抗糖尿病新药N-Me-DNJGAL-DNJfagomine,,,,[8]4.3开发功能性食品17,[4],,#24#2003371:[1].()[M].:,1997.[2].[M].:,1960.[3].()[M].:,1979.[4],.)))[J].,2000,21(1):46.[5],,.(1))))[J].,1996,13(1):24.[6].[J].,1999,21(4):218.[7]ASANON,TOMIOKAE,KIZUH,etal.SugarswithnitrogenintheringisloatedfromtheleavesofMorusbombycis[J].CarbohydrRes,1994,253:235-245.[8]KIMURAM,CHENF.AntihyperglycemiceffectsofN-contain-ingsugarsderivedfrommulberryleavesisstreptozocin-in-du-ceddiabeticmice[J].WakanIyakugakuZasshi,1995,12(3):214-219(eng).[9].[J].-,2000,22(4):232.[10],,.[J].,2000,(1):33-35.[11].[J].-,1999,21(4):54.[12].[J].-,1999,21(3):54.[13]ITOM,TAKEGUCHIT.Beveragecontainingdeoxynojirimy-cinforcontrollingbloodsugar[P].Japan:97140351,1995-11-21.[14]HOSSEINZADEHH,SADEGHIA.AntihyperglycemiceffectsofMorusnigraandMorusalbainmice[J].PharmPharma-colLett,1999,9(2):63-65.AREVIEWONCHEMICALCONSTITUENTS,PHARMACOLOGICALACTIVITYANDAPPLICATIONOFMULBERRYLEAVESZOUSheng-qin,CHENWu(TheGraduateSchoolofBio-enineering,YichunUniversity,Yichun336000,China)Abstract:MulberryleavescontainN-containingsugars,rutin,quercetin,volatileoil,aminoacid,vitaminsandmicroele-ments,whichhavesomanypharmacologicalactivitiessuchasreducingbloodglucose,antihyperlipidemia,hypertensive,bac-teriostasisandantivirus.ThereareplentifulmulberryleavesinChina,andtherewouldbeabrightdevelopingandstudyingfutureoftheleavesformedicaluseaswellasfunctionalfoods.Keywords:mulberryleaf;chemicalconstituent;pharmacologicalactivity(:2002-10-11)#25#2003371