选择性5--羟色胺再摄取抑制剂治疗早泄的研究进展

ChineseJournalofAndrologyVol.22No.22008200233prematureejaculationPE20%~30%PE[1]PE16%~23%[2]5-5-50%intravaginalejaculationlatencytimeIELTDSM-IVAUA[3,4]1234[5]5-5-HT5-HT[6]5-HT5-HT5-HT1A5-HT5-HT1B5-HT5-HT1B5-HT5-HT5-HT5-HT155-HT75-HT1-75-HT35-HTG-[7]5-HT5-HT1A5-HT1B5-HT2C5-HT1B5-HT2C5-HT1A[8]5-selectiveseroto-ninre-uptakeinhibitorsSSRIs5-HT5-HTSSRIs5-HT5-HT5-HT1A5-HT1B5-HT5-HT1A5-HT1B5-HT5-HT[9]20SSRIs1~2[10]SSRIs[11]Waldinger[12]SSRIs5-HT5-HT12SSRIsPEWaldinger[13]303479SSRIs5-HT582008222SSRIsSSRIsED5-HT2CSSRIs[14]Adson[15]SSRIsPEPEPEPE5.4hIELT21s36sSSRIs[16]3SSRIsSSRIs30mg60mg60~80min42%30mg60mg90min24h4%24h13hIELT3[17]SSRIsPEPE[18]Giuliano[19]1310mg/kg60min1mg/kgSSRIsPE330mg60mg1~3hPEEDSSRIs5-20mg100mg60mg[20]Andersson[21]3PE1~3h30mg60mg30mg60mgIELT3~4IELT60mgIELT55s145sSSRIsPESSRIsSSRIs5-HTSSRIs5-HT5-HT5-HT1A5-HT1B5-HT5-HT5-HT1A5-HT1BSSRIs5-HTSSRIs5-HT5-HT1A5-HT1B5-HT5-HTSSRIsSafarinejad[22]PE6IELT30s450s12IELT383134s17937055sIELT5-5-5-HT5-HT1A5-HT1B5-HT2C[8]ChineseJournalofAndrologyVol.22No.22008PE5-HT1AlthofSE.JUrol2006;175(3Pt1):842-8482PerelmanMA.JSexMed2006;3(6):1004-10123AmericanPsychiatricAssociation.Diagnosticandstatisticalmanualofmentaldisorders.4thed.TextRevision.WashingtonDC:AmericanPsychiatricAssociation2000:684MontagueDK,JarowJ,BroderickGA,etal.JUrol2004;172(1):290-2945XuC,YaiciED,VergeD,etal.Neuroscience2006;138(2):561-5736GiulianoF,ClementP.EurUrol2005;48(3):408-4177WoltersJP,HellstromWJ.RevUrol2006;8(suppl4):S18-S258DeJongTR,VeeningJG,WaldingerMD,etal.NeurosciBiobehavRev2006;30(7):893-9079WaldingerMD,SchweitzerDH,OlivierB.JSexMed2005;2(1):121-13110WongDT,PerryKW,BymasterFP.NatRevDrugDiscov2005;4(9):764-77411GiulianoF.TrendsNeurosci2007;30(2):79-8412WaldingerMD,OlivierB.CurrOpinInvestigDrugs2004;5(7):743-74713WaldingerMD,ZwindermanAH,SchweitzerDH,etal.IntJImpotRes2004;16(4):369-38114Quintin,P,ThomasP.Encephale2004;30(6):583-58915AdsonDE,KotlyarM.AnnPharmacother2003;37(12):1804-180616WaldingerMD,SchweitzerDH,OlivierB.JSexMed2005;2(1):121-13117PryorJL,AlthofSE,SteidleC,etal.Lancet2006;368(9539):929-93718ModiNB,DresserMJ,SimonM,etal.JClinPharmacol2006;46(3):301-30919GiulianoF,BernabeJ,GengoP.JUrol2007;177(1):386-38920DresserMJ,DesaiD,GidwaniS,etal.IntJImpotRes2006;18(1):104-11021AnderssonKE,MulhallJP,WyllieMG.BJUInt2006;97(2):311-31522SafarinejadMR.ClinNeuropharmacol2006;29(5):243-252200706081Altan-YayciogluR410324h24h30d30d130dP0.05P0.0530d11130dP0.05P0.0530d11200025