马齿苋的化学成分和药理活性研究进展_丁怀伟

2510200810JournalofShenyangPharmaceuticalUniversityVol125No110Oct12008p1831:2007-12-14:(1980-),(),,,[e-mail];(1970-),(),,,,,Tel.[phone],[e-mail]:1006-2858(2008)10-0831-08丁怀伟,姚佳琪,宋少江(,110016):,,;,;,:;;:R914;R96;R932:A(PortulacaoleraceaL.),,,,,,[1]289,,,78,2008,,,1111A-(A-linolenicacid)[2],(47116%)(22100%)(1714%),(45186%)(30116%)[3][4],,,7[5]8Award[6]22,17,(erucicacid)(arachidicacid)(linolenicacid)(palmiticacid)(caprylicacid)(pelargonicacid)(capricacid)(hendecanoicacid)(margaricacid)(stearicacid)(behenicacid)(lauricacid)(oleicacid)(myristicacid)(lig-nocericacid)(linoleicacid)(palmitoleicacid)[7]GC-MS,3,7,11,15--2-19[8]5,8,11,14,17-(EPA)4,7,10,13,16,19-(DHA)[9](suc-cinicacid,)[10](caffeicacid)[11](benzoicacid)112,(quercetin,1)(kaemferol,2)(myricetin,3)(apigenin,4)(lu-teolin,5)(hesperidin,6)[10](genistein,7)-7-O-B-D-(genistin,8)[6][12]6137%1~81Fig.1StructuresofflavonoidsfromPortulacaoleraceaL11133-(3-acetylaleuritolicacid,9)(friedelin,10)[13]A-(A-amyrin,11)B-(B-amyrin,12)(butyrospermol,13)(parkeol,14)(cycloartenol,15)[14](lupeol,16)4A--3B--(4A-methy-l3B-hydroxylfriedelan,17)[15]E(tocophero1,18)A(portulo-sideA,19)B(portulosideB,20)(3S)-3-O-(A-D-)-3,7---1,5--3,7-((3S)-3-O-(A-D-glucopyra-nosyl)-3,7-dimethylocta-1,5-dien-3,7-diol,21)(3S)-3-O-(A-D-)-3,7---1,6--3-((3S)-3-O-(A-D-glucopyranosyl)-3,7-dimethylocta-1,6-dien-3-ol,22)[16]9~222114(daucosterol)B-(B-sitoserol)-4--3-(stigmast-4-en-3-one)[17]115(noradrenaline,23)(dopamine,24)(dopa,25)N--(N-trans-feruloyltyramine,26),N,N-(N,N-dicyclo-hexylurea,27)(allantoin,28),A(oleraceinA,29)B(30)C(31)D(32)E(33)(adenosine)[18]3--6--2,5-(3-iso-buty-l6-methylpiperazine-2,5-dione,34)3--6--2,5-(3-sec-buty-l6-methylpiperazine-2,5-dione,35)3-(4--)6--2,5-(3-(4-hydroxy-benzyl)-6-benzylpiperazine-2,5-dione,36)[9][11](uracil,37)23~3731166,7-(6,7-dihydroxy-coumarin,38)[9](scopoletin,39)(bergapten,40)(isopimpinellin,41)lonchocarpicacid(42)lonchocarpenin(43)(robustin,44)[19]38~444117Ñ(oleracinÑ)[20]Ò(oleracinÒ)(acyatedbeta-cyanins)5-O-B-(5-O-B-cellobiosideofbetanidin)5-O-B-(5-O-B-cellobiosdeofisobetanidin)83225Fig.2StructuresofterpenesfromPortulacaoleraceaL.83310:Fig.3StructuresofalkaloidsfromPortulacaoleraceaL.Fig.4StructuresofcoumarinsfromPortulacaoleraceaL.83425118,,(K2O)1%,17%,[21]1191911%,[22]1110C20~C26[1]290-2912211,,[23],,,,[24],[25],/0212,,,,,,,,,[26]213Harvey[27],,Parry[28],6214,[29],,,,215Simopoulos[30]X-3,10,,,[31],,,,,,,,,,216[32][33],,,,C,217[34],T,SMMC7721,S180.S180,N-83510:(NDMA),[35],NDMA,NDMA,7014%4716%,218ECB-(SOD),,[36][37]D-,100200400mg#kg-1,(GSH-Px),SODGSH-Px,,,219[38](3H-TdR)DNA,,,[39]7d,,,,,2110[40],,,,[41],l7,2111LD501040mg#kg-1[18]3(),,,,,,,,,,,,,,,,:[1].:[M].:,1975.[2]LIUL-ixia,PETERH,ZHOUYe-fang,etal.Fattyacidsandb-caroteneinAustralianpurslane(Portulacaoleracea)varieties[J].ChromatographyA,2000,893(1):207-213.[3],,,.[J].,1995,14(5):70-72.[4],,.[J].,1996,14(1):50-52.[5],,.[J].,2006,21(2):198-201.[6]AWADNE.LipidcontentandantimicrobialactivityofphenolicconstituentsofcultivatedPortulacaoleraceaL[J].BullFacPharmCairoUniv,1994,32(1):137-142.[7],,,.GC-MS[J].:,1994,14(3):72-74.[8].2--2--[J].,2004,25(5):83625154-158.[9],,,.[C]..:,2006:204.[10],,,.[J].,2007,30(10):64-68.[11],,,.[J].,2007,19(B11):398-399.[12],.[J].,2003,20(1):128.[13],,,.[J].,2007,24(12):751-753.[14],.[M].:,2002:100-101.[15]SUNJian,ZHANGHong-gui,ZHANGJing-min,etal.ChemicalconstituentsfromPortulacaoleraceaL[J].JournalofChinesePharmaceuticalSciences,2004,13(4):291-292.[16]SEOY,SHINJ,LEEBJ,etal.Twobiophenolicgly-cosidesfromPortulacaoleracea[J].KorChemSoc,2003,47(1):43-46.[17],.[J].,2005,33(6):1090-1092.[18]XIANGLan,XINGDong-ming,WANGWei,etal.AlkaloidsfromPortulacaoleraceaL[J].Phytochem-istry,2005,66(21):2595-2601.[19],,,.[J].,2006(7):64-68.[20].[M].:,1994:446-452.[21],,,.[J].,1989,4(1):88-89.[22],,,.[J].,2000,19(1):49-50.[23],.[J].,2000,31(1):43-44.[24].[J].,1992,12(1):36-38.[25]FENGPC,HAYNESLJ,MAGNUSKE.Highcon-centrationof(-)-noradrenalineinPortulacaoleracea[M].Nature,1961,191:1108.[26]METHIS.[J].:,1989,11(1):57.[27]HARWEYAL.[J].:,1993,8(1):32.[28]OKWUASABAF.[J].:,1988,10(5):41.[29].[J].,1999,24(2):133-135.[30]SIMOPOULOSAP,NORMANHA,GILLASPYJE,etal.Commonpurslane:Asourceofomega-3-fattyacidsandantioxidants[J].JAmCollNutr,1992,11(4):374-382.[31],,.[J].,1997,31(2):91.[32],.[J].,1995,17(4):85-86.[33],.[J].,2007,25(5):38-41.[34],,,.[J].:,2002,17(1):73-76.[35],,,.[J].,1998,20(3):361-365.[36],,,.[J].,1997,28(5):284.[37],,,.[J].,2006,22(1):35-37.[38],,,.PHA[J].,1996,18(3):206-207.[39],,.[J].,2006,22(3/4):89-90.[40],,.[J].,2007,19(6):39-41.[41].[J].,2007,2(4):83.83710:ResearchprogressonchemicalconstituentsandpharmacologicalactivitiesofPortulacaoleraceaL.DINGHua-iwei,YAOJia-qi,SONGShao-jiang(SchoolofTraditionalChineseMateriaMedica,ShenyangPharmaceuticalUniversity,Shenyang110016,China)Abstract:ObjectiveToreviewresearchprogressinthechemicalconstituents,processingofthechemicalconstituents.accumulationandthepharmacologicactionofPortulacaoleraceaL.andprovideareferenceforthefurtherr