10.黄秋云;赤芍急性毒性实验观察;2008

黄秋云,张锦铭,李丹(350001):对发生不良反应的批次赤芍开展调研,探讨其发生不良反应的原因模拟临床赤芍的用量用法,将赤芍予小白鼠灌胃给药,并设置相应的对照组,观察给药后动物的不良反应情况在观察的120只样品组小白鼠中,5只小白鼠出现死亡,另有95只出现毛松,肌软,活动减少,呼吸减慢等不良反应该批次赤芍确实有毒性反应:赤芍;不良反应:R92712:A:1006-3765(2008)-10-0040-02:,(1954-);:ObservationofacutetoxiceffectsofRedpeonyrootHUANGQiu-yun,ZHANGJin-ming,LIDan(FujianFuzhouHospitalofTCM,Fuzhou350001,China)ABSTRACT:OBJECTIVESAftersurvingofRedpeonyroot,whichpatientswereallergictothedrug,weinves-tigatethereasons.METHODSObserveadversereactionoftheratsaftertheyweregivenRedpeonyrootbygav-age,controlgroupwasgivenNS.RESULTSTherewere5ratsoftheobservedgroup(120rats)werediedand95ofthemdecreasedtheirspontaneousmovementsaswellastherespirationrates.CONCLUSIONSThatbatchofRedpeonyroothassometoxicity.KEYWORDS:Redpeonyroot;Adversereaction200636,(,,,,,),:¹º,À,¼,½,,,,,,,,,,,:111111111:(1)611112:,200,,a`,18~22g,:0005296::SYXK()2006-0002:11113:11211211:6,10,a`,12h,(014mL/10gbw),LD5011212,6,7,20,a`12h,6(014mL/10gbw),40g#kg-1,6h1,2,80g/(kg#d),,31,14d2211:40g#kg-1,10min,,,,,,,90min,2,,,30min6h,,40g#kg-1,,14d;,,,1/20#40#200820101(g#mL-1)()200g,15min,30min200mL1200512122006814200g,15min,30min200mL1200512122006814200g,15min,3h,200mL1200512122006814200g,15min,30min200mL1200512142006814200g,15min,30min200mL1200512122006814200g,15min,30min200mL1200606282006814212:,35min,1,1/20213:,214:,,40min,12,2/20215:,100min,5,1/20216:,217,218,615,,202(3h),(),,(2)2()40g/(kg#),6h1,2,80g#kg-11/2040g/(kg#),6h1,2,80g#kg-11/2040g/(kg#),6h1,2,80g#kg-1040g/(kg#),6h1,2,80g#kg-11/2040g/(kg#),6h1,2,80g#kg-11/2040g/(kg#),6h1,2,80g#kg-103,,,,,56/,,,,,0,,20068108B13200mL,8B58,;9B07,,96/,200mL,30min,,,,,15B00,,,,,,9,:(Ñ),(Ò),(Ó),(Ô),4--(Õ),(Ö),(×),(Ø),B(Ù)112,,,;,;;,,,,,112,,11J21,2006,29(4):267-2691#41#StraitPharmaceuticalJournalVol20No.102008