子宫内膜再生干细胞研究进展

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*100730*E-mailzhu_julie@vip.sina.com【】。。、。【】【】R711.74【】A【】1674-4020201603-0006-04doi10.3969/j.issn.1674-4020.2016.03.03、、、、。400、、、1。。、、。。。12/3、。、。242。。、3。4。、。/W5C5+CD146+PDGF-Rβ+5-6。/、。GaideChevronnay7。·6·CHINESEJOURNALOFFAMILYPLANNING&GYNECOTOKOLOGYVolume8Number32016estrogenreceptorERαprogesteronereceptorPR8。Wnt9。WntWnt4Wnt5aWntSFRP2WntDNA10。WntAXIN211。Wnt。。vascularendothelialcellgrowthfactorVEGF。VEGFVEGF2neuropilinsNP1VEGF12。13。β1。。ER。13-14。ERERαPR。。15。matrixmetalloproteinasesMMPsactivin、-βtransforminggrowthfactorβTGF-βVEGF15。。、/16。2、。、、“Asherman”17。/、、、、、17。。。。14。18。。、、19。/20。/6。3。Foley。3.1%~23.5%20%~62.5%17。·7·20168321。。、、、、。/、/6。BoneMarrowDerivedStemCellsBMDSCs22。、6。1623BMDSCs。BMDSCs。Taylor24BMDSCsBMDSCs。2。Nagori25BMDSCs33、。。invitrofertilizationIVF8。Singh266Ⅲ-Ⅳ。、、。3、6、9。。BMDSCsBMDSCs、、/。、、。、、。【】1JABBOURHNKELLYRWFRASERHMetal.EndocrineregulationofmenstruationJ.EndocrineReviews200627117-46.2SAMUELSPTANA-k.FetalscarlesswoundhealingJ.TheJournalofOtolaryngology1999285296-302.3MAYBINJCRITCHLEYH.RepairandregenerationofthehumanendometriumJ.ExpertReviewofObstetrics&Gynecology200943283-298.4LUDWIGHSPORNITZUM.MicroarchitectureofthehumanendometriumbyscanningelectronmicroscopymenstrualdesquamationandremodelingJ.AnnalsoftheNewYorkAcademyofSciences199162228-46.5MASUDAHANWARSSBüHRINGHJetal.Anovelmarkerofhumanendometrialmesenchymalstem-likecellsJ.CellTransplantation201221102201-2214.6GARGETTCEYEL.EndometrialReconstructionfromstemcellsJ.FertilityandSterility201298111-20.7GAIDECHEVRONNAYHPGALANTCLEMOINEPetal.SpatiotemporalcouplingoffocalextracellularmatrixdegradationandReconstructioninthemenstrualhumanendometriumJ.Endocrinology2009150115094-5105.8GARGETTCENGUYENHPYEL.Endometrialregenerationandendometrialstem/progenitorcellsJ.ReviewsinEndocrine&MetabolicDisorders2012134235-251.9VANDERHORSTPHWANGYongyiVANDERZEEMetal.InteractionbetweensexhormonesandWNT/β-cateninsignaltransductioninendometrialphysiologyanddiseaseJ.MolecularandCellularEndocrinology20123582176-184.10HOUXiaonanTANYiLIMeilingetal.CanonicalWntsignalingiscriticaltoestrogen-mediateduterinegrowthJ.MolecularEndocrinologyBaltimoreMd.200418123035-3049.11NGUYENHPSPRUNGCNGARGETTCE.DifferentialexpressionofWntsignalingmoleculesbetweenpre-andpostmenopausalendometrialepithelialcellssuggestsapopulationofputativeepithelialstem/progenitorcellsresideinthebasalislayerJ.Endocrinology201215362870-2883.23·8·CHINESEJOURNALOFFAMILYPLANNING&GYNECOTOKOLOGYVolume8Number32016【】1.J.201191144-145.2.J.2014412603-604.3MUFTIACOUTTSPSIBBALDRG.ValidationofcommerciallyavailableinfraredthermometersformeasuringskinsurfacetemperatureassociatedwithdeepandsurroundingwoundinfectionJ.AdvancesinSkin&WoundCare201528111-16.4.J.201031244200-4201.5.J.201421215386-53875454.6.42J.201423582-83.7SHAHNAWAZKHANMABDELHAMIDHNWUHui-fen.NearinfraredNIRlasermediatedsurfaceactivationofgrapheneoxidenanoflakesforefficientantibacterialantifungalandwoundhealingtreatmentJ.ColloidsandSurfacesB-Biointerfaces2015127127281-291.8.J.201210121063-1064.9.J.2014238909-910.10.J.2014228186.11.Ⅲ~Ⅳ31J.2014135444-445.12SANTOSJDDEOLIVEIRASMDASILVAFMetal.Low-levellasertherapyforpainreliefafterepisiotomyadouble-blindrandomisedclinicaltrialJ.JournalofClinicalNursing20122123/243513-3522.13.J.201334233496-3497.14.TDPJ.201319132048-2050.15SONGDYBURDETTEECFIENEJetal.RoboticneedleguideforprostatebrachytherapyclinicaltestingoffeasibilityandperformanceJ.Brachytherapy201110157-63.16.J.201334142166-2167.17.ⅢJ.200925233625-3626.18.J.200414101130.2015-06-03812FANXiu-junKRIEGSKUOCJetal.VEGFblockadeinhibitsangiogenesisandreepithelializationofendometriumJ.FASEBJournal200822103571-3580.13PATTERSONALZHANGLingARANGONAetal.Mesenchymal-to-epithelialtransitioncontributestoendometrialregenerationfollowingnaturalandartificialdecidualizationJ.StemCellsandDevelopment2013226964-974.14BIGSBYRM.ControlofgrowthanddifferentiationoftheendometriumtheroleoftissueinteractionsJ.AnnalsoftheNewYorkAcademyofSciences2002955110-117discussion118396-406.15SALAMONSENLA.TissueinjuryandrepairinthefemalehumanreproductivetractJ.ReproductionCambridgeEngland20031253301-311.16DUHonglingNAQVIHTAYLORHS.Ischemia/reperfusioninjurypromotesandgranulocyte-colonystimulatingfactorinhibitsmigrationofbonemarrow-derivedstemcellstoendometriumJ.StemCellsandDevelopment201221183324-3331.17YUDanWONGYMCHEONGYetal.Ashermansyndrome--onecenturylaterJ.FertilityandSterility2008894759-779.18REIDPCTHURRELLWSMITHJHetal.NdYAGlaserendometrialablationhistologicalaspectsofuterinehealingJ.InternationalJournalofGynecologicalPathologyOfficialJournaloftheInternationalSocietyofGynecologicalPathologists1992113174-179.19SCHENKERJG.EtiologyofandtherapeuticapproachtosynechiauteriJ.EuropeanJournalofObstetrics&GynecologyandReproductiveBiology1996651109-113.20GARGETTCEHEALYDL.GeneratingreceptiveendometriuminAsherman'ssyndromeJ.JournalofHumanReproductiveSciences20114149-52.21MYERSEMHURSTBS.ComprehensivemanagementofsevereAshermansyndromeandamenorrheaJ.FertilityandSterility2012971160-164.22DUHTAYLORHS.StemcellsandreproductionJ.CurrentO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