薏苡化学成分及其活性综述

1000-1003.14HuHaobinZhengXudongHuHuaishengetal.Acylat-edStilbeneGlucosidesandFurtherConstituentsfromAc-anthopanaxbrachypusJ.HelvChimActa2009922546-554.15.J.198811637-37.16.D.201061-104.17.J.19895145-47.18.-J.199114235-37.*250012、。。、、。。R284/R285A1001-4454201108-1306-0720[e-mail]。*[e-mail]。Coixlacroyma-jobiL.var.ma-yuenStapf、。SemenCoicis、、《》〔1〕。2010。。2060。1、、、、、〔23〕。GC-MS55、、、4〔45〕。2060、70、、、、Benzoxazinone、Benzoxazalinone、、、、、、、、1。116-102691036910469105Coixenolide11126α-α-Monolinolein13·6031·JournalofChineseMedicinalMaterials348201187CoixspirolactamA14158CoixspirolactamB14159CoixspirolactamC141510CoixspirolactamD1511CoixspirolactamE1512Coixlactam141513Methyldioxindole-3-acetate141514Methyldioxindole-3-acetate15151616-1617Coniferylalcohol1718Syringicacid1719Ferulicacid1720Threo-l-C-syringylglycerol1821Erythro-l-C-syringylglycerol182226-dimethoxy-p-hydroquinone-l-O-β-D-glucopyranoside1823Zhepiresionol1524Ficusal1525Syringaresinol17264-Ketopinoresinol171827Mayuenolide17283S3aR6aS-36-dibenzod13dioxol-5-yltetrabydro-furo34-cfuran-l3H-one18Benzoxazinone29Benzoxazinone11930Benzoxazinone21931Benzoxazinone31932Benzoxazinone41933Benzoxazinone519Benzoxazalinone34Coixol1935Isoindol-1-one153635-Dimethoxy-1H-inden-1-one2037Eriodictyol16·7031·JournalofChineseMedicinalMaterials34820118382'6-Dihydroxy-4'-methoxydihydroauronol213957-Dihydroxychromone21405-Hydroxy-7-methoxychromone2141Davidigenin2142Isoliquiritigenin2143Naringenin2144Homoeriodictyol2145Hesperetin2146Liquiritigenin2147Chrysoeriol214834'57-Tetramethoxyflavone214933'4'57-Pentamethoxyflavone2150Tangeretin215133'4'5678-Heptamethoxyflavone2152Formononetin2153Coixspiroenone155422552256α-2357β-2358τ-235923602361Feruliylphytosterol2362Friedlin232463Isoarborinol232464ACoixanA2565BCoixanB2566CCoixanC2567CA-12668CA-22669～751～72776Adenosine187724·8031·JournalofChineseMedicinalMaterials348201182、、、、〔28〕。、、、、、、、。2.1。1957EhrlichEhrlich〔29〕。1961Ukita〔11〕23-。1984ICRS180〔29〕。1994Numata〔6〕。S180。。GC、、。S180。α-Monolinolein。Tokuta〔13〕、TPAICR。。、、、〔30〕。。PaTu-8988SW1990G2/McDNAPaTu-898824p21p27CDK2cyclinsbcl-2baxATMRAD50p53〔31〕。〔32〕PaTu-8988、Hoechst33258、、TUNEL。〔33〕HeLaHeLaFasFasL。〔3435〕CNE-2Z、。。。Lee〔14〕Ad-laybranABM-EtOAcA549、HT-29COLO205。5coixspirolactamAcoixspirolactamBcoixspirolactamCcoixlactammethyldioxindole-3-acetate。MTT53IC5028.57～72.57μg/mL。。F344ACF〔36〕。。F344AOM5ACFACF52〔37〕。ABE-EtOAc12-DMHF344。17.28mgRASEts2·9031·JournalofChineseMedicinalMaterials34820118Weel-2COX-2ABE-EtOAc。HPLCABE-EtOAcABE-EtOAc〔38〕。2.2BenzoxanzinoidAE。2〔39〕。。40Coixol。AdlayhullAHERAW264.7。AHEiNOSCOX-2NOPGE2。iNOSCOX-2〔16〕。2.3ECLJAMPAMPKT3-L1。AMPKAMPK2ECLJAMPKAMPKAMPK。EOFJ2〔41〕。A、B、Calloxan〔25〕。〔4243〕。Wistar4、、〔44〕。2.4Ishiguro〔20〕35-Dimethoxy-1H-inden-1-one。、、。2.5。CA-1CA-2。CA-1、、、、1.8∶43.8∶10.8∶33.2∶3.2∶7.216CA-2、、、、、、2.4∶37.0∶11.8∶1.7∶35.6∶2.9∶2.6∶6.07。CA-2CA-1。7glucanO-61→4α-D-〔26〕。AdlaytestaATE-EtOAcRBL-2H350μg/mLATE-EtOAcA23187RBL-2H3。ATE-EtOAcIL-4IL-6TNF-α。p-ERKATE-EtOAcRBL-2H3p-ERKATE-EtOAcMAPK〔45〕。OVAOVA-IgEOVA-IgGTh1/Th2Th2Th1〔46〕。2.6。〔22〕。ABM。ABMABM-BuOHStARP450P450sccmRNA〔47〕2.7。620。。COX-2ERK〔48〕。·0131·JournalofChineseMedicinalMaterials348201182.8DPPHAdlayhullDPPH6〔14〕。3、、、、、、、FDA〔49〕。。。1《》．M．8．1999329．2．J．199812162-66．3ApirattananusornSTongtaSCuiSWetal．Chemicalmo-lecularandstructuralcharacterizationofalkaliextractablenonstarchpolysaccharidesfromJob'stearsJ．JournalofAgriculturalandFoodChemsitry200856188459-8557．4．J．1992110-13．5．M．1975922．6NumataMYamamotoAMoribayashiAetal．AntitumorcomponentsisolatedfromtheChineseherbalmedicineCoixlachryma-jobiJ．PlantaMedica1994604356-359．7．J．199910299-101．8．J．200122560-62．9.GS-MSJ．200831111613-1614．10.J．1999228405．11UkitaTTanimuraA．Studiesontheanti-tumorcomponentintheseedofCoixlachryma-jobiL．var．ma-yuenRo-man．StapfⅠ．Isolationandanti-tumoractivityofcoix-enolideJ．PlantaMedica19619143-46．12TanimuraA．Studiesontheanti-tumorcomponentintheseedofCoixlachryma-jobiL．var．ma-yuenRoman．StapfⅡ．ThestructrueofcoixenolideJ．PlantaMedica19619147-53．13TokudaHMatsumotoTKonoshimaTetal．InhibitoryeffectsonEpstein-Barrvirusactibationandanti-tumorpromotingactibitiesofCoixseedJ．PlantaMedica1990566653-654．14LeeMYLinHYChengFetal．Isolationandcharacter-izationofnewlactamcompoundsthatinhibitlungandco-loncancercellsfromadlayCoixlachryma-jobiL．var．ma-yuenStapfbranJ．FoodandChemicalToxicology20084661933-1939．15ChungCPHsuCYLinJHetal.Antiproliferativelac-tamsandspiroenonefromadlaybraninhumanbreastcancercelllinesJ.JournalofAgriculturalandFoodChemistry20115941185-1194.16HuangDWChungCPKuoYHetal．IdentificationofcompoundsinadlayCoixlachryma-jobiL．var．ma-yuenStapfseedhullextractsthatinhibitlipopolysaccharide-inducedinflammationinRAW264.7MacrophagesJ．JournalofAgriculturalandFoodChemistry2009572210651-10657．17KuoCCChiangWLiuGPetal.22'-Diphenyl-l-pic-rylhydrazylradical-scavengingactivecomponentsfiomad-layClixlachryma-jobiL.var.ma-yuenStapfhullsJ.JournalofAgriculturalFoodChemsitry200250215850-5855.18OtsukaHTakeuchiMInoshir