对中药_毒性_与毒性分级的思考_关建红

关建红1*,翁维良2(1.山西中医学院,山西太原030024;2.中国中医科学院西苑医院,北京100091)[]2007-09-15[](30672639)[]*,E-mai:[e-mail],,,,,,,,,,,,,,,,,,,11.1,,,,,,31:,,,:,,,,,:,,,,2:,:,,,,,,,,,,3:,,,,:,,,1.2120,120,125,,,,,,,,,,,,,,131,143,223,361,,,,,,;,,1892,239,22,120,78,19,,,,,,,,,,48533420082中国中药杂志ChinaJournalofChineseMateriaMedicaVo.l33,Issue4February,2008,[1],2,,,:,,;,,,,,,,,,22.1(LD50)LD50,LD50LD505gkg-1;LD505~15gkg-1;LD5016~50gkg-1;LD5050gkg-12005[2]15:15,LD505245gkg-1,350,LD5039724gkg-1,2648,75LD50,,,LD50,LD50,2.2,(1)[3],[4],3[5][6],1LD505gkg-15~15gkg-116~50gkg-13g3~12g13~30g10min10~30min30min,,,豨莶草为:豨莶草水煎剂的LD501467gkg-1,LD504143gkg-1[7]2005,863,2437,20min,,2~5h,()[8],,,,3,,豨莶草,,,,3,,,,,,,,,,,豨莶草,中国药典未标明有毒,动物实验则显,,,,,,(),,,,,48633420082中国中药杂志ChinaJournalofChineseMateriaMedicaVo.l33,Issue4February,2008,,,,,,,,,,,3.1,,:;;;;;;;;;,,3.22005253710,15(),LD50,(),(LD50),,,豨莶草为:豨莶是菊科植物,分为豨莶草腺梗豨莶毛梗豨莶,它的豨莶的每一品种进行半数致3:,,,,,,,,,,,,,,3.3LD50,,,豨莶草为例,只依靠LD50,,,,,,,,,,,,,,,,[][1].[J].,1994,6(4):113.[2].15[J].,2005,6(11):435.[3].[M].:,1993:14.[4].[J].,1996,7(2):4.[5],.[M].:,2003:78.[6],.[M].:,1997:24.[7].豨莶草水煎醇沉物对小鼠的急性毒性[J].中国中药,2005,30(21):1564.[8].豨莶草水煎剂小鼠急性毒性及亚急性毒性的实验研究[J].,2007,13(11):49.[]48733420082中国中药杂志ChinaJournalofChineseMateriaMedicaVo.l33,Issue4February,2008