超滤法去除细菌内毒素

30520019JOURNALOFHYGIENERESEARCHVol.30No.5Sep.2001315:100028020(2001)0520315202,300160:,,(90mm500mm),150LPhatm,6000,,;,::R197139:BStudyontheeliminationofbacterialendotoxinsbyultrafiltrationdeviceWangZheng,ZhangHuixin,DaiHaipingMembraneSCI&TECHINSTofTianjinPolytechnicUniversity,Tianjin300160,ChinaAbstract:Anexternal2pressedpolysulfonehollowfiberUFmembrane,wasmadebyphaseinversionmethod.Thecut2offmolecularweightwas6000.Thewaterpermeationrateofthismembranemodule(90500mm)ismorethan150LPhr.atm.Theoperatingresultsshowthattheeliminationofbacterialendotoxinsbythismembranehasreachedthenationalstandardinpharmacopoeia,andthistechnologyisworthytobeextendedovertomedicalindustry.Inaddition,theessenceofpyreotogen,thequantificationunitsandmeasuremethodsforpyreotogen,andtheoperatingconditionsofUFdeviceintheprocessofeliminatingpyreotogenareintroduced.Somecriticalpointsinoperationwasdiscussed.Keywords:bacterialendotoxins,hollowfiber,ultrafiltration:,,,,();;;;,,,(01110),,,5100,,,,;,,(1)(),,,1mm,014mm,,,,,,,11,,,(),A11111111,,150nm,A,,,,11112,100,120498%,180,2,11113,©1994-2006ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.(),,,,5ngPml,(kg)50ng,016[1],;,,,,,:1EUPml113[2],,,,(5100nm),,221121111(1),(2)1(m)(m)4009010060002(mm)(mm)(m2)(LPhatm)10000905008150(2),,11213141516171813191101111121221221211,50000ml,,320116MPa,8,47000ml,200ml0185%(gPml)NaCl,2121216830mL,10169%,32,0115012MPa45,11900ml,(4000ml,34%),200ml,0185%NaCl,213-:3,,016,3114,3311,(3)3()123()()(P)(1)01751162114511273182130(1)012001050135012001600212221421180211561441150013501100135012701800:(1),32:,,,,017511621145,1127(0160),3182,(114),,012,0160,;,(21150127)3,,6000,,(),,,,,;,,312,(318)61330©1994-2006ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.(0177%),3311,1,7,312,,,,,,313(),,,,,,314,,,,,,,,,,,(2000210225)(316),,,,,,,,,,313,,,,,,,,,314,,,-,,315,,,,19[3],,,41..:2..1996,5175262..,1992,4034063.().:,1995,425(2000212207)()81330©1994-2006ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.