Th1-Th2平衡调节与疾病发生的研究进展

*△310053TTh1/Th2Th1/Th2Th1Th2Th1/Th2。Th1Th1Th2Th2。Th1/Th2、、、。Th1/Th2。Th1/Th2Q78Q813A1673-6273200913-2597-04AdvancesofRegulationTh1/Th2TypeCytokinesBalanceinHumanDiseases*YAOJin-jing,CHENYi-tao△CollegeofLifeScience,ZhejiangChineseMedicalUniversity,Hangzhou,310053,Zhejiang,ChinaABSTRACT:Undernormalcircumstances,thesubsetsofThelperlymphocyteswereinbalance.TheTh1/Th2imbalanceandthetrendoftransformationtoTh1orTh2statewasTh1/Th2drift.Customarily,theTh1cellandTh1cytokinedominatedstatewereknownasTh1state,whiletheTh2cellandTh2cytokinedominatedstatewascalledasTh2state.TheTh1/Th2balancewascloselyrelatedtothedevelopment,treatment,andprognosisofmanydiseases.ThepaperreviewedtherelationshipbetweenTh1/Th2balanceandhumandiseases,aswellastherelatedresearch.Keywords:Th1/Th2imbalance;tumors;cytokineChineseLibraryClassificationCLC:Q78,Q813Documentcode:AArticleID:1673-6273200913-2597-04*No.20050817No.2007YA0051986-E-mail:[e-mail]△Tel[phone]E-mail:[e-mail]2009-05-042009-05-301986Mosmann[1]CD4+TIL-2IFN-γTh1IL-4IL-5Th2。T[2]Th1Th1IL-2、TNF-βIFN-γTh2IL-4、IL-5、IL-6、IL-10IL-13。Th1/Th2Th1/Th2。Th1/Th2。Th1/Th2。1Th1/Th2、APCTh0Th1Th2Th1Th2。APCThpThp'Th0ATh0BIL-2、IL-4IL-2、IL-4IFN-γIL-4Th0Th1Th2。IL-4Th0ATh2IL-4IFN-γTh0BTh1Th1IFN-γTh2IL-4IL-10。2Th1/Th2Th1Th2。Th1、TCTL、DTH。Th2IL-4BIgE、。2.1Th1/Th2Th1/Th2Th1/Th2[3-8]。Th1/Th2T[3,4]。、、、、、、、、、2597··[5-8]。Th1Th1Th2Th1。IL-2IFN-γIL-10Th0Th2。Th2。、、、、、、、、Th2。[9]Th2Th2。2.2Th1/Th2Th1/Th2。、I、Th1Th1。、HIVTh2。Th1Th2Th1/Th2[10]。、Th1/Th2Th2Th2、Th2Th2Th2Th1[11]。2.3Th1/Th2Th1/Th2Th1Th2、Th1Th0、Th2Tc。Clerici[12]HIVTh2IL-4IFN-γIL-4IL-12Th2HIVHIVTTh0。CHB、、Th2CHBHBsAgTh1Th2CHBPBMCIL-10Th1CHB[13]。Th1/Th2。Lin[14]Azouzou[15]Th1Th2。Zhang[16]mRNATh1Th2。Surcel[17]IFN-γTh1IL-4Th2IL-4。Azouzou[15]Th1-Th2Th2。Barnes[18]Th1Lin[14]IFN-γT。、IFN-γIL-2。Th1/Th2。、、Th1/Th2[10]。3Th1/Th2Th1/Th2、Th1/Th2。3.1Th1/Th2[19-21]。Th1Th1/Th2Th1Th2Th2。[19]2NKTh1IFN-γrhIL-12Th2IL-10McAbTh2KarpasIL-4HL60NK。[20]PcDNA3-IL-16KarpasTTh2Th0IL-16。3.2Th1/Th2。IL-12B-7Th0Th1。[22]GHPcDNA-GHcDNAT-JurkatGHAIL-2RIL-2IFN-γGH。B-7Th1/Th2。3.3IFAIFATh2。Th2IFA。IL-4MBPT/IFAIFATh1Th2[23]。3.4。Th1/Th2。[24]2598··。[25]Th1/Th2Th1。3.5Th1/Th2Th1/Th2Th。Hultgren[26]HBcAgHBeAgPBMCIL-2IFN-γTh1/Th2Th1/Th2Comabella[27]Th1Th1Th1pentoxifyllineTh1。3.6NONOIL-2IFN-γIL-4Th1/Th2Th2。NOTh1/Th2NOCPP32Bcl-2Th2。3.7Th1/Th2。[28]、Th1/Th2IL-2Th1Th2。Th1/Th2。4Th。Th1/Th2Th1Th2。Th。References[1]MosmannTR,ChewinssreH,BondMW,etal.TwotypesofmurineThelpercellclone:definitionaccordingtoprofilesoflymphokineac-tivitesandsecretedproteins[J].JImmunol,1986,136(7):2348-2357[2]RomagnaniS.HumanTh1andTh2subsets;doubtnomore[J].Immu-nalToday,1991,12(8):256-257[3]BorChingSheu,RongHwaLin,HuangChunLien,etal.PredominantTh2/Tc2Polarityoftumor-infiltratinglymphocytesinhumancervi-calcancer[J].Immunology,2001,167(5):2972-2978[4],.[J].,2001,8(1):72-74ZhangXuan,CaoXue-tao.ChineseJournalofCancerBiotherapy,2001,8(1):72-74(inChinese)[5]HHatanaka,YAbe,TKamiya,etal.Clinicalimplicationsofinter-leukin(IL)-10inducedbynon-small-celllungcancer[J].AnnalsofOncology,2000,11(7):815-819[6],,,.Th1/Th2[J].,2001,39(1):92HuYong-sheng,ZhangQing-lin,TianZhi-gang,etal.ChieseJournalofSurgery,2001,39(1):92(inChinese)[7]BaisAG,IBeckmann,LindemansJ,etal.AshifttoaperipheralTh2-typecytokinepatternduringthecarcinogenesisofcervicalcancerbecomesmanifestinCINlesions[J].ClinicalPathology,2005,58(10):1096-1100[8],,,.Th1[J].,2007,29(7):581-583ZhangYang,CaoYing-ping,YangSheng,etal.PatternonTh1/Th2inpatientwithprimaryhepaticcarcinomaanditschangesafteropera-tion[J].NingxiaMedicalJournal,2007,29(7):581-583(inChinese)[9],,,.Th1/Th2[J].,2000,20(6):432-434GuoAi-lin,SuiYan-fang,FanQing-yu,etal.DisregulationinTh1/Th2subsetsofCD4+Tcellsinperipheralbloodofpatientswithmetastasticbonecancers[J].Tumor,2000,20(6):432-434(inChinese)[10],,,.Th1-Th2[J].,2002,38(4):366-368LiuJia-hong,WangYing-nian,ZhaoYun-feng,etal.ActaAcadimaeMedicinaeQingdao,2002,38(4):366-368(inChinese)[11],,.Th1/Th2[J].,1998,21(1):55-58WeiHai-ming,LiuJie,TianZhi-gang.ChineseJournalofLaboratoryMedicine,1998,21(1):55-58(inChinese)[12]ClericiM,ShearerGM.ATh1→Th2switchisacriticalstepintheetiologyofHIVinfection[J].ImmunolToday,1993,14(3):107-111[13],,,.Th1/Th2[J].,2001,21(2):8HuZhang-yong,ZhangLian,WenWei-qun,etal.ChineseJournalofMicrobiologyandImmunology,2001,21(2):8(inChinese)[14]LinY,ZhangM,FlorenceM,etal.AbsenceofaprominentTh2cy-tokineresponseinhumantuberculosis[J].InfectionandImmunity,1996,64(4):1351-1356[15]AzouzouN,PetrofskyM,YongLS,etal.Mycobacteriumaviumin-fectioninmiceisassociatedwithtime-relatedexpressionofTh1andTh2CD4T-lymphocyteresponse[J].Immunology,1997,91(3):414-420[16]ZhangM,LinY,DinakarV,etal.Tcellcytokineresponsesinhumaninfectionwithmycobacteriumtuberculosis[J].InfectionandImmunity,1995,63(8):3231-3234[17]SurcelHM.Th1/Th2profilesintuberculosis,basedontheprolifera-tionandcytokineresponse