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:(B1069)691,2,2,3,3,4(1.;2.;3.;4.,610041):69,150691:1,SF-36,4(P0.01)(P=0.017)(P=0.015)(P0.01)4,(P=0.289),(P0.001)69,,,:;;QualityoflifeAmong69monthssurvivorsofstrokeZHANGJun,GUBo,LUODe-ru,etal.DepartmentofSpecialMedicineservices,theFirstHospital,WestChinaUniversityofMedicalscienses,Chengdu,610041Abstract:ObjectiveTheconsequencesofstrokeareamajorhealthconcern.Thisstudywasconductedtocomparethequalityoflifeamong69monthssurvivorsofstrokewiththatofgeneralpopulation.MethodsAdopting1:1pairedcase-controlstudyof69monthssurvivorsofstrokewithanaged-andsex-matchedcontrolpopulationwithrespectively150cases.ApplyingSF-36toevalu-atetheirqualityoflifebyself-rating.ResultsMeanscoreswerelowerforwomeninphysicalfunctioning,rolelimitationsduetophysicalproblems,socialfunctionalandvitality(allP0.01);Generalhealth(P=0.017),physicalfunctioning(P=0.015),vitalityandmentalhealth(P0.01)decreasedwithaging.CasepatientshadlowermeanscoresthancontrolgroupforallhealthdimensionsinSF-36qualityoflife(P0.001)butbodilypain.ConclusionQualityoflifeseemstoberatherbadforthemajorityofpatients69monthsafterstroke.Besidesseriousphysicaldysfunction,thereareseriousobstaclesinmentalhealth,socialfunc-tioningandrolelimitations.SoinChinesecommunityhealthservices,itshouldbestrengthenedinmentalhealthservicesandsocialfunctioningones,especiallyforfemalecases.Keywords:Strokeoutcome;Qualityoflife;Compare:R743.3:A:1005-8559(2001)06--,,,,,,,,,69,,,,,,69,,1.:1998919993187,69(8,29),CTMRI,,MMSE15150,42,82,65.3792,586041,606956,7063MMSE22.582.:,,1:1(),2,P0.1870.5260.744SF-36(36)[12][34],[5]SF-36,,,,,,9352001106foxpro6.0,spss8.0,(Wilcoxon)1.:,1:()spearman12.:KruskalWallis(2),,(P=0.017)(P=0.015)(P=0.003)(P=0.001)4,69Wilcoxon,3,(P=0.289),(P0.001),69,,spear-man4,:(),4(P0.01),,,(P0.05)1(xs)60(n=41)54.3218.6878.5422.7868.2939.5475.6142.1875.9132.7682.6117.3764.3912.7169.8512.656069(n=56)53.2919.9468.4828.5553.1244.4873.8142.0364.5133.5283.5417.9563.3915.6172.6413.6070(n=53)50.2621.7352.4530.7540.5744.1969.8145.8744.3434.7275.4023.3555.8515.8966.9416.42*:,2KruskalWallis(xs)(n=92)68.2219.4555.8717.7669.7328.9457.6143.5078.2639.3663.7235.8483.2417.9963.9714.36(n=58)58.4722.6147.1622.7158.9729.8945.2644.5464.3647.9055.3935.6775.9122.5056.2915.8525.715.872.7823.512.103.4608.6210.98P0.0170.0150.0950.0610.1470.0630.0030.0013(xs)ZP60.9718.0852.5020.20-3.370.00186.1012.4965.5729.68-6.650.00091.3325.4152.8344.17-7.160.00091.7824.7172.8943.24-4.570.00088.0817.7060.5035.89-7.310.00083.1418.4980.4120.11-1.060.28970.3313.9861.0015.37-4.990.00076.5612.8769.8714.53-3.930.0004spearman(xs)-0.29-0.04-0.39-0.39-0.06-0.39-0.08-0.22-0.04P0.0000.5940.0000.0000.4390.0000.3090.0070.6450.070.16-0.11-0.070.02-0.020.14-0.020.11P0.3840.0450.1710.3660.8260.7280.0760.8050.16669,,,,69,SF-368,,,045ChineseJournalofBehavioralMedicalScience10(6),200169,,,:,,,,,,,,4::,??,,,,??:(P=0.03)(P=0.01),,,69,,,,,,,MareeL.Hackett(2000)6SF-36,,[6],,(CMB),[][1]WareJE,SnowKK,KosinskiM,etal.SF-36HealthSurveymanualandinterpretationguide.Boston,MA:TheHealthInsti-tute,NewEnglandMedicalCenter,1993.[2],,,.36[J].,2001,32(1):3942.[3]Hobson-P,Bhowmick-B,Meara-J.UseoftheSF-36question-naireincerebrovasculardisease[A].Stroke.1997,28(2):464465.[4]OMahonyPG,RodgersH,ThomsonRG.IstheSF-36suitableforassessinghealthstatusofolderstrokepatients[J].Age-Age-ing,1998,27(1):1922.[5],,,.SF-36[J].,2001,10(5):416420.[6]HackettML,DuncanJR,AndersonCS,etal.Health-relatedqualityoflifeamonglong-termsurvivorsofstroke:resultsfromtheAucklandStrokeStudy,19911992[J].Stroke.2000,31(2):440447.:,,28,,,:2001-04-04:()PXOVXAchOVXPX,ADEMTEMTAD,ADEMT,EMTAD[][1]KuszakJ,RodinMA.Newtechniqueofpinealecomyforadultrats.Experientia[J].1977,33:283284.[2].[J].,1997,24(5):259261.[3]BruscoLI,MarquezM,CardinaliDP.MonozygotictwinswithAlzheimersdiseasetreatedwithmelatonin[J].J-Pineal-Res,1998,25(4):260263.[4],,.[J].,1997,18(5):193196.[5]ReganRF,GuoY.Estrogenattenuateneuronalinjuryduetohemoglobin,chemicalhypoxiaandexcitatoryaminoinmurinecorticalcultures[J].BrainRes,1997,764:133140.[6].[J].,1999,32(3):134136.[7]KavaliersM,HirstM,CampbellTG.Aging,opioidanalgesiaandthepinealgland[J].lifeSci,1983,32:22792287.[8]GolombekDA,EscolarE,BurinLJ,etal.Chrnopharmacologyofmelatonin:inhibitionbybenzodiazepineantagonism[J].Chrono-biolInt,1992,9:124131.[9]SunnerBE,FinkG.Testosteroneaswellasestrogenincreasesserotonin2AreceptormRNAandbindingsitedensitiesinthemaleratbraine[J].MolBrainRes,1998,59:205214.[10]StoneDJ,RozovskyI,MorganTE,etal.IncreasedsynapticsproutinginresponsetoestrogenviaanapolipoproteinE-depen-dentmecaanism:implicationsforAlzheimersdisease[J].neu-rosci,1998,18(9):31803185.[11]StoneDJ,RozovskyI,MorganTE,etal.AstrocytesandmicrogliarespondtoestrogenwithincreasedapoEmRNAinvivoandinvitro[J].ExpNeurol,1997,143:313318.[12]VollrathL,WullhorstT,SeidelA.Theresponseisoproterenolofsynapticribbonnumbersintheratpinealglandchangesduringpostnataldevelopment[J].NeurosciLett,1995Apr21,189(3):187189.[13]GibbsRB.Impairmentofbasalforebraincholinergicneuronsasso-ciatedwithagingandlongtimelossofovarianfu