原位凝胶研究进展及质量控制要点

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©1994-2010ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.:(1985-),,,,;(1968-),,,,,,(,430065)::():,:,:,,:;;pH;;:R943:A:167322197(2009)0320141202[1],(),,,(inSituFormingEyeGe1)-,pH,12080[2],FDA,INSITEVISION,DURASITE[3],,pH(insituformingeyege1),,(),2,,2.1,,(-),407188-(PEG-PLA)-MaWD[4]-,,/,,2.2pHpH,pH,,,(PAA)pH,;(-N,N-)(PDEAEM)pH141©1994-2010ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.[5]pHpHpH:()JainSP[6]980NF,(MethocelK100LV),,pH,,24h98%2.3K+Na+Ca2+,:Merck,FDA3,,,,,(-),,3.120mL30mL,1min-1,,[7],33.23.2.1,,,,[8]3.2.2-,,()3.340mL50mL,1min-1,[9]3.4SONGCHENGJUN[10]:6,25L,25L,10S,,,24,,(),,,,,,,:[1]NANJAWADEBK,MANVIFV,MANJAPPAAS.JInsitu2forminghydrogelsforsustainedophthalmicdrugdelivery[J].ControlRelease,2007.[2]LINDELLK,ENGSTROMS.Invitroreleaseoftimololmaleatefromallinsitugellingpolymersystem[J].IntJPharm,1993,95:219.[3],,.[J].,2004,39(3):232.[4]MAWD,XUH,NIESF,etal.Temperature2responsive,Plu2ronic2g2poly(acrylicacid)copolymersinsitugelsforophthalmicdrugdelivery:rheology,invitrodrugrelease,andinvivoresi2dentproperty[J].DrugDevIndPharm,2008,34(3):258266.[5],,,.[J].,2004,23(5):411244.[6]JAINSP,SHAHSP,RAJADHYAKSHANS,etal.Insituophthalmicgelofciprofloxacinhydrochlorideforonceadaysus2taineddelivery[J].DrugDevIndPharm,2008,34(4):445252.[7],,,.[J].,2007,16(13).[8],,,.[J].,2008,11(9).[9],,,.[J].,2005,21(5):3832386.[10]SONGCJ,WANGY,WANGCY,etal.Preparationande2valuationinvivoofscutellariathermosensitivegel[J].ChinaJournalofChineseMateriaMedica,2008,33(6):628231.(:)241

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