原发性青光眼流行病学研究进展

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··1210100592010017、。、.cuiwei1957yanke@163.com2011-11-292012-03-08ProgressinepidemiologicalstudiesofprimaryglaucomainChinaJunWang1WeiCui21OphthalmologyMajorGraduateSchoolofInnerMongoliaMedicalCollegeHohhot010059InnerMongoliaAutonomousRegionChina2DepartmentofOphthalmologyInnerMongoliaPeople'sHospitalHohhot010017InnerMongoliaAutonomousRegionChinaCorrespondencetoWeiCui.DepartmentofOphthalmologyInnerMongoliaPeople'sHospitalHohhot010017InnerMongoliaAutonomousRegionChina.cuiwei1957yanke@163.comReceived2011-11-29Accepted2012-03-08AbstractGlaucomaistheprimarycauseofinreversibleblindness.Asthechangeofsocietyeconomyandenvironmentandtheimprovementofthewaysofdiagnosisandtreatmentofglaucomatheepidemiologicalfeatureisalsochangingincessantly.Sincedifferentdiagnosticstandardandclassificationsystemofglaucomaleadtodifferentsurveyresultofepidemiologyandtheepidemiologicalfeaturegivesdirectiontotheclinicalinterveningmeasurethesituationofglaucomaepidemiologyisofgreatimportancetoprophylaxisandtreatmentofglaucoma.ThisthesisgivesanoverviewoftheprogressinresearchfieldofprimaryglaucomaepidemiologyinChina.KEYWORDSepidemiologyglaucomaprevalencerateriskfactorsWangJCuiW.ProgressinepidemiologicalstudiesofprimaryglaucomainChina.GuojiYankeZazhiIntEyeSci2012124667-670。、、。。。。DOI10.3969/j.issn.1672-5123.2012.04.20..2012124667-6700。。Quigley1202020207960600。、、。1、、。。primaryangleclosureglaucomaPACG1987“”5《》PACGPACG、、、。“”internationalsocietyofgeographicalandepidemiologicalophthalmologyISGEOPACG。PACG321primaryangleclosuresuspectPACS。2primaryangleclosurePACPACS、、、PAC。PAC。3PACGPACPACG。ISGEO1ISGEOglaucomatousopticneuropathyGONPACG。2ISGEOPACG766IntEyeSciVol.12No.4Apr.2012.ies.net.cnTel029-8224517282210956EmailIJO.2000@163.comPACPACG。3ISGEOPACPACPACG。POAG。331。2。3。retinalnervefiberlayerRNFLPOAG4。POAG。31、。2。3。4。5。。POAG。POAG。22.12.1.1PACG199655555PACG1.66%198550PACG1.99%61997750PACG1.0%。20038、38500≥502125PACG1.63%。2006950PACG1.5%。PACG。PACG1、、。2。3。2.1.2POAGPOAGPOAG、。1985104722151085110414POAG0.11%19965>504888POAG0.29%POAG11。198712POAG0.07%。20011353404451POAG1.97%2.07%POAG1.04%1.42%。1504POAG2.1%14。200915405158579POAG1.73%。POAGPACG。POAG1、、2。2.22.2.1PACG2.2.1.11101985PACG1294058±10。145089.68%。PACG。1695%50。17。21245310.13%0.47%。7199750PACG0.8%1.2%。13PACGPACG1.7%0.8%。PACGPACG。3PACG。199018、、20、20PACG0.08%400.15%0.62%1.37%。199819PACG3.02。201020PACG、、PACG。2.2.1.2PACG、、、86620124124.ies.net.cn029-8224517282210956IJO.2000@163.com。。17PACGPACG。21APACG1.780±0.328mm2.067±0.261mm2.457±0.296mmPACG。PACG。222AlconA/BA10.84±0.428mm11.64±0.513mm21.85±1.019mm23.15±16.215mm。-。321UBMAPACG582±208μm650±125μmP<0.05。PACG。2.2.1.3PACGPACG。23PACG7.10%2.33%。300.96%24P<0.001。2.2.1.42515682.1%、。2613851A、AATHCHTH+CHP<0.05P<0.01EPQNLP<0.05P<0.01。AA。2.2.2POAG2.2.2.1271995/2000POAG107POAG149logisticPOAG。POAG。1mmHgPOAG12.5%~52.9%。2.2.2.2。285050、、C/D、1502550.0%2383503570.0%2550.0%1734.0%1734.0%76.0%。。2.2.2.329182355219163。210.4%。304%~11%3。311692008-10/2010-1012060、60A、A、2h3.3%A13.3%AP<0.01。POAG。。。2.2.2.432R2038POAGPOAG、、、、EAIKP<0.050.01。POAGEAIPOAG。2.2.2.5highmyopiaHM。33HMPOAG1.20%0.12%。3478.72%62.22%P=0.0140。966IntEyeSciVol.12No.4Apr.2012.ies.net.cnTel029-8224517282210956EmailIJO.2000@163.com35、。HM。2.2.2.62009405158POAG1.73%15。362008501743POAG0.40%200914419140POAG0.26%37。POAGPOAGPOAG。2.2.2.738422∶=1∶1。POAGPOAGPOAGPOAGMYOC/TIGROPTNWDR36CYP1B1POAG39POAGMYOC/TIGR2%~4%POAGMYOC/TIGRPOAGMYOC/TIGR、40。3。POAG。。。。1QuigleyHABromanAT.Thenumberofpeoplewithglaucomaworld-widein2010and2020.BrJOphthalmol2006903262-2692.ISGEO.200848181073..2010315682-6844..200682-835.50.2002386335-3396..2005256573-5757..2000213212-2148..2005551037-10429.50.2007209774-77610..1989252115-11911..200618471-7512..1995312149-15113..20044011726-73214HeMFosterPJGeJetal.PrevalenceandclinicalcharacteristicsofglaucomainadultChineseapopulation-basedstudyinLiwanDistrictGuangzhou.InvestOphthalmolVisSci20064772782-278815..2010427817-81916.5.201143121-2317LeskeMCHusseinMBengtssonBetal.Factorsforglaucomaprogressionandtheeffectoftreatmenttheearlymanifestglaucomatrial.ArchOphthalmol2003121148-5618..199026247-5019..1998102269-27120..2010287454-45821..1998345365-36822..2002204284-28523..198521295-10124.40.2005238782-78425..199819158-5926.A.200133174-17627..2002234293-29628..20039320229.2.200830121941-194230..1.200450131..201122493-9432..200010293-9433..1986226349-35234..2010482523-2435..20094229-3236.50.20093222079-208137..20102119169-17338..2010501899-10039AllinghamRRLiuYRheeDJ.Thegeneticsofprimaryopen-angleglaucomaareview.ExpEyeRes20098811837-84440.MYOC/TIGR.2004226669-67207620124124.ies.net.cn029-8224517282210956IJO.2000@163.com

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